Ketamine and the Oxyhemoglobin Dissociation Curve

Te, Bageant; Wc, Petty

doi:10.1213/00000539-197311000-00009

Cited by 5 publications

(2 citation statements)

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“…The standard bicarbonate and whole blood based excess values in group C documented the presence of a metabolic component contributing to the developing acidotic state. Since ketamine produces no change in haemoglobin affinity for oxygen (Bageant &. Petty 1973) the combined respiratory and metabolic acidosis is due to the increased pC0 2 and to hypoxia which, in tum, is a result of the decreased oxygen saturation and impaired peripheral circulation.…”

Section: Respiratory Parameters and Acid-base Statusmentioning

confidence: 99%

Acid-base status and cardiovascular function in mink (Mustela vison) anaesthetized with ketamine/midazolam

1996

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Heart rate, arterial blood pressure and blood acid-base status were determined in 18 adult female mink (mean (+/- SEM) body weight 1052 +/- 34 g) during long-term anaesthesia with either controlled ventilation (n=12) or spontaneous respiration (n=6). Surgical anaesthesia was induced by intramuscular injection of ketamine hydrochloride (Ketaminol Vet, 40.0 +/- 1.7 mg/kg) and midazolam hydrochloride (Dormicum 2.8 +/- 0.1 mg/kg) and maintained for at least 5 h by continuous intravenous infusion of this drug combination in 0.9% saline. For all animals, the mean rates of infusion of ketamine and midazolam were 48.4 +/- 1.6 and 1.61 +/- 0.12 mg/h, respectively. Following continuous infusion of the anaesthetics in isotonic saline, at a rate of 20 ml/h, a moderate 'dilution acidosis' developed, which could be corrected by replacement of part of the saline with sodium bicarbonate to a final concentration of approximately 25 mmol NaHCO3 per litre. However, when the animals were allowed to breathe spontaneously, an increase in heart rate and a combined respiratory and metabolic acidosis occurred, due to severe respiratory depression. Apart from these effects and a few cases of increased salivation, no adverse effects over time were observed on the arterial blood acid-base status and cardiovascular function of the animals during ketamine/midazolam anaesthesia. It is concluded that the procedure described for long-term anaesthesia in mink is convenient and safe for acute physiological experiments in this species, provided normal body temperature and pulmonary gas exchange is sufficiently maintained. Thus, the need for an adequately controlled artificial ventilation is strongly emphasized. Finally, a proposal for the composition of an intravenous solution, containing ketamine and midazolam hydrochloride, and sodium bicarbonate in saline, suitable for long-term anaesthesia in adult mink is presented.

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Section: Respiratory Parameters and Acid-base Statusmentioning

confidence: 99%

Acid-base status and cardiovascular function in mink (Mustela vison) anaesthetized with ketamine/midazolam

1996

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“…showed a substantial decrease in the haemoglobin-oxygen (Hb-O 2 ) affinity in their study in anaesthetized men. The possibility that anaesthesia alters this affinity was investigated in vitro in respect of various anaesthetic agents, although no positive finding was obtained (Millar, Beard and Hulands, 1971;Waltemath, 1971Waltemath, , 1972Weiskopf, Nishimura and Severinghaus, 1971;Bageant and Petty, 1973;Carden and Petty, 1973). No data for Althesin are available.…”

mentioning

confidence: 99%

The Effect of Althesin (Ct1341) on the Oxyhaemoglobin Dissociation Curve in Vitro

Ishikawa

Wakuta

Kanda

et al. 1976

British Journal of Anaesthesia

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Blood from non-smoking donors was incubated with Althesin and the PO2 for half-saturation of haemoglobin at standard pH, PCO2 and temperature (P 50) was measured. The mean P 50 values of blood with blood concentrations of Althesin of 0.14 ml/dl and 0.42 ml/dl were greater (1.14 +/- 0.31 (SEM) mm Hg (P less than 0.005) and 2.22 +/- 0.35 (SEM) mm Hg (P less than 0.001), respectively) than that of control blood. These increases were dose-dependent (P less than 0.05). Erythrocyte 2,3-diphosphoglycerate (2,3-DPG) concentrations were not significantly different between the Althesin-treated and the control blood. Although a decrease in the affinity of haemoglobin for oxygen in vitro in the presence of Althesin was statistically significant, this would have no clinical significance if the drug was being used for the induction of anaesthesia only.

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Spectrophotometric measurement of hemoglobin oxygen saturation in the opossum Didelphis virginiana

Petty

Bethlenfalvay

Bageant

1975

Comparative Biochemistry and Physiology Part A: Physiology

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Ketamine and the Oxyhemoglobin Dissociation Curve

Cited by 5 publications

References 0 publications

Acid-base status and cardiovascular function in mink (Mustela vison) anaesthetized with ketamine/midazolam

Acid-base status and cardiovascular function in mink (Mustela vison) anaesthetized with ketamine/midazolam

The Effect of Althesin (Ct1341) on the Oxyhaemoglobin Dissociation Curve in Vitro

Spectrophotometric measurement of hemoglobin oxygen saturation in the opossum Didelphis virginiana

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