Ketamine Blocks Morphine-Induced Conditioned Place Preference and Anxiety-Like Behaviors in Mice

McKendrick, Greer; Garrett, Hannah; Jones, Holly E.; McDevitt, Dillon S.; Sharma, Suresh D.; Silberman, Yuval; Graziane, Nicholas

doi:10.3389/fnbeh.2020.00075

Cited by 38 publications

(27 citation statements)

References 132 publications

(167 reference statements)

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“…CPP fundamentally tests the incentive value of contexts, and how environmental conditions contribute to the formation of drug-context associations. The long-term nature of drug context-seeking behavior is evident in our CPP paradigm, in which we observe a robust CPP with 28 days of abstinence following conditioning and drug exposure (McKendrick et al, 2020a ). In line with this finding, the motivation to seek a context associated with a drug is seen by the induction of approach behaviors, with CPP tests following conditioning (Aguilar et al, 2009 ), which can persist for 12 weeks without any additional drug exposure (Mueller et al, 2002 ).…”

Section: Conditioned Place Preference Combined With Oral Self-adminismentioning

confidence: 55%

“…These negative states can be physiological, including withdrawal and craving, but also psychological, such as anxiety and depression, and both separately or combined, may be relieved by drug exposure during conditioning, thus facilitating CPP. For example, we found that 5 days of repeated morphine exposure elicits anxiety-like behaviors as well as CPP and that removing the morphine-induced anxiety-like behavior using ketamine is sufficient to block morphine CPP (McKendrick et al, 2020a ). Since we did not observe any physiological signs of withdrawal, such as jumping, wet dog shakes, teeth chattering, rearing, tremor, and diarrhea [which coincides with the lack of observed somatic withdrawal symptoms following a more prolonged injection regimen of five daily morphine (10 mg/kg, i.p.)…”

Section: Factors To Consider When Interpreting Conditioned Place Prefmentioning

confidence: 99%

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Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

McKendrick

Graziane

2020

Front. Behav. Neurosci.

Self Cite

144

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The conditioned place preference (CPP) paradigm is a well-established model utilized to study the role of context associations in reward-related behaviors, including both natural rewards and drugs of abuse. In this review article, we discuss the basic history, various uses, and considerations that are tied to this technique. There are many potential takeaway implications of this model, including negative affective states, conditioned drug effects, memory, and motivation, which are all considered here. We also discuss the neurobiology of CPP including relevant brain regions, molecular signaling cascades, and neuromodulatory systems. We further examine some of our prior findings and how they integrate CPP with self-administration paradigms. Overall, by describing the fundamentals of CPP, findings from the past few decades, and implications of using CPP as a research paradigm, we have endeavored to support the case that the CPP method is specifically advantageous for studying the role of a form of Pavlovian learning that associates drug use with the surrounding environment.

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Section: Conditioned Place Preference Combined With Oral Self-adminismentioning

confidence: 55%

Section: Factors To Consider When Interpreting Conditioned Place Prefmentioning

confidence: 99%

Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

McKendrick

Graziane

2020

Front. Behav. Neurosci.

Self Cite

144

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“…In line with this finding, another study examined motivational behavior through the conditioned place preference of morphine, where the level of anxiety in mice was evaluated while they were performing open arm and sucrose preference tasks. The results revealed that ketamine reduced the anxiety-like effects and prevented morphine-induced conditioned place preference [75]. In line with this, buprenorphine, although it is limited its abuse liability, has shown better tolerability and efficacy profile as adjunctive therapy, especially in treatment-resistant depression [76].…”

Section: Neurochemical Cascades and Other Mechanismsmentioning

confidence: 56%

“…Hydroxynorketamine metabolites play a role in potentiating events mediated by α-amino-3hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors [75]. AMPAR are ionotropic transmembrane glutamatergic receptors, and the principal receptors mediating fast synaptic neurotransmission in the brain.…”

Section: Metabolitesmentioning

confidence: 99%

The Ketamine Antidepressant Story: New Insights

Alshammari

2020

Molecules

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Ketamine is a versatile agent primarily utilized as a dissociative anesthetic, which acts by blocking the excitatory receptor N-methyl-d-aspartate receptor (NMDA). It functions to inhibit the current of both Na+ and K+ voltage-gated channels, thus preventing serotonin and dopamine reuptake. Studies have indicated that administering a single subanesthetic dose of ketamine relieves depression rapidly and that the effect is sustained. For decades antidepressant agents were based on the monoamine theory. Although ketamine may not be the golden antidepressant, it has opened new avenues toward mechanisms involved in the pathology of treatment-resistant depression and achieving rapid antidepressant effects. Thus, preclinical studies focusing on deciphering the molecular mechanisms involved in the antidepressant action of ketamine will assist in the development of a new antidepressant. This review was conducted to elucidate the emerging pathways that can explain the complex dose-dependent mechanisms achieved by administering ketamine to treat major depressive disorders. Special attention was paid to reviewing the literature on hydroxynorketamines, which are ketamine metabolites that have recently attracted attention in the context of depression.

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“…Ketamine has been suggested to have beneficial effects in treating drug addiction. Rodent studies have shown that ketamine reduces ethanol consumption in alcohol-preferring rats [76,77] and reduces morphine-induced place preference [78]. Several clinical studies provide support for the potential of ketamine in the treatment of alcoholism as well as opioid and cocaine addiction and cannabis use disorder [79][80][81][82][83][84][85].…”

Section: Psychiatric Usementioning

confidence: 99%

Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms

Kohtala

2021

Pharmacol. Rep

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Over the past 50 years, ketamine has solidified its position in both human and veterinary medicine as an important anesthetic with many uses. More recently, ketamine has been studied and used for several new indications, ranging from chronic pain to drug addiction and post-traumatic stress disorder. The discovery of the rapid-acting antidepressant effects of ketamine has resulted in a surge of interest towards understanding the precise mechanisms driving its effects. Indeed, ketamine may have had the largest impact for advancements in the research and treatment of psychiatric disorders in the past few decades. While intense research efforts have been aimed towards uncovering the molecular targets underlying ketamine’s effects in treating depression, the underlying neurobiological mechanisms remain elusive. These efforts are made more difficult by ketamine’s complex dose-dependent effects on molecular mechanisms, multiple pharmacologically active metabolites, and a mechanism of action associated with the facilitation of synaptic plasticity. This review aims to provide a brief overview of the different uses of ketamine, with an emphasis on examining ketamine’s rapid antidepressant effects spanning molecular, cellular, and network levels. Another focus of the review is to offer a perspective on studies related to the different doses of ketamine used in antidepressant research. Finally, the review discusses some of the latest hypotheses concerning ketamine’s action.

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Ketamine Blocks Morphine-Induced Conditioned Place Preference and Anxiety-Like Behaviors in Mice

Cited by 38 publications

References 132 publications

Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

The Ketamine Antidepressant Story: New Insights

Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms

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