Ketamine does not decrease postoperative pain after remifentanil‐based anaesthesia for tonsillectomy in adults

Elstraete, Alain C. Van; Lebrun, T.; Sandefo, Ignace; Polin, Bruno

doi:10.1111/j.1399-6576.2004.00399.x

Cited by 33 publications

(23 citation statements)

References 21 publications

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“…9,12,13 On the other hand, several clinical studies including pediatric trials failed to show an analgesic and/or morphine-sparing effect. [14][15][16] This inconsistency in clinical benefit of ketamine may be caused by the optimal period and regi- Although precise time periods of central sensitization, OIH, and acute tolerance were not clarified, NMDA receptor could be activated throughout the perioperative period. Central sensitization is evoked by repetitive and highfrequency noxious stimulus from C-fibers via activation of NMDA receptor, which could in turn occur by pain stimulation not only during surgery but also at any time in the postoperative period.…”

Section: Discussionmentioning

confidence: 96%

Intra‐ and postoperative low‐dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial

Minoshima

Kosugi

Nishimura

et al. 2015

Acta Anaesthesiol Scand

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Section: Discussionmentioning

confidence: 96%

Intra‐ and postoperative low‐dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial

Minoshima

Kosugi

Nishimura

et al. 2015

Acta Anaesthesiol Scand

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“…In 8 trials, a perioperative use of ketamine was administered [11,[22][23][24][25][26][27][28]. In 5 trials, a preoperative bolus of magnesium sulfate was followed by a continuous infusion throughout surgery [29][30][31][32][33].…”

Section: Systematic Searchmentioning

confidence: 99%

The efficacy of N-methyl-d-aspartate receptor antagonists on improving the postoperative pain intensity and satisfaction after remifentanil-based anesthesia in adults: a meta-analysis

Huang

Lee

2015

Journal of Clinical Anesthesia

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“…Some studies have documented an opioid sparing effect of perioperative iv low-dose ketamine 4-8 and others have not. [9][10][11][12][13][14] These discrepancies may be due to the large interstudy variability in surgical procedures, patient population, dose of ketamine administered, timing of administration, and study design. 15,16 In studies that fail to demonstrate a preventive effect of a low-dose ketamine on postoperative pain, the question of whether a lack of efficacy on central sensitization is linked to insufficient pre-or postoperative blockade remains unresolved.…”

Section: Methodsmentioning

confidence: 99%

Lack of a pre-emptive effect of low-dose ketamine on postoperative pain following oral surgery

Lebrun¹,

Elstraete²,

Sandefo³

et al. 2006

Can J Anesth/J Can Anesth

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Purpose: The aim of this study was to assess the effect of pre-vs postincisional low-dose iv ketamine on postoperative pain in outpatients scheduled for oral surgery under general anesthesia. Methods:Eighty-four patients were randomly assigned to receive intravenously saline before and after surgery in Group 1, ketamine 300 µg·kg -1 iv before and saline after surgery in Group 2, saline before and ketamine 300 µg·kg -1 iv after surgery in Group 3. Postoperative analgesia consisted of iv proparacetamol and ketoprofen. Rescue analgesia consisted of nalbuphine 200 µg·kg -1 iv. Analgesia at home consisted of oral ketoprofen, and acetaminophen with codeine as rescue analgesia. A telephone interview was conducted on the first and second postoperative days.Results: There were no significant differences between groups with respect to pain scores, the number of patients requiring nalbuphine in the postanesthesia care unit (PACU), (36.7%, 38.7%, and 39.5% for Groups 1, 2, and 3 respectively), or nalbuphine consumption in the PACU (66.5 µg·kg -1 ± 16.8, 75.9 µg·kg -1 ± 17.5, 66.7 µg·kg -1 ± 21.6 for Groups 1, 2, and 3 respectively). The number of rescue analgesic tablets taken at home, and time to first request for rescue analgesia, sedation scores, or side-effects were similar amongst groups. No patient required nalbuphine in the ambulatory care unit. Conclusions: There was no benefit to pre-emptive administration of ketamine 300 µg·kg -1 iv whether administered pre-or postoperatively. (36,7 %, 38,7 %, et 39,5 % respectivement pour les Groupes 1, 2 et 3), la consommation de nalbuphine (66,5 µg·kg -1 ± 16,8, 75,9 µg·kg -1 ± 17,5, 66,7 µg·kg -1 ± 21,6 respectivement pour les Groupes 1, 2 et 3), le nombre de comprimés de secours à domicile : 6 (2,13), 7 (2,20), et 7 (1,12) Objectif

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Ketamine does not decrease postoperative pain after remifentanil‐based anaesthesia for tonsillectomy in adults

Abstract: Small-dose of ketamine does not seem to be a useful adjunct to remifentanil-based anaesthesia during short, painful surgical procedures.

Cited by 33 publications

References 21 publications

Intra‐ and postoperative low‐dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial

Intra‐ and postoperative low‐dose ketamine for adolescent idiopathic scoliosis surgery: a randomized controlled trial

The efficacy of N-methyl-d-aspartate receptor antagonists on improving the postoperative pain intensity and satisfaction after remifentanil-based anesthesia in adults: a meta-analysis

Lack of a pre-emptive effect of low-dose ketamine on postoperative pain following oral surgery

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