Ketamine impairs response inhibition and is positively reinforcing in healthy volunteers: a dose?response study

Abstract

The lack of residual effects in healthy volunteers on day 3 indicates that impairments found on day 3 in ketamine abusers are chronic effects. The abuse of ketamine may be related to its capacity both to reinforce and to decrease response inhibition.

Acute and chronic effects of ketamine upon human memory: a review

“…intact retrieval. This encoding deficit has been noted on recognition memory tasks (Honey et al 2005a;Hetem et al 2000), recall tasks (Morgan et al 2004b) and a virtual Morris water maze (Rowland et al 2005). Pre-clinical support for ketamineinduced encoding impairment is provided by studies describing NMDA antagonist-induced deficits in acquisition (i.e.…”

Acute ketamine challenge increases resting state prefrontal-hippocampal connectivity in both humans and rats

“…Ketamine has been applied in humans (D'Souza et al 2012;Krystal et al 2005;Morgan et al 2004) and animals (Garcia et al 2008;Pitsikas et al 2008;Skoblenick and Everling. 2012) to model translationally relevant behavioral effects.…”

Ketamine-Enhanced Psychotherapy: Preliminary Clinical Observations on its Effects in Treating Death Anxiety

“…In fact, there is a plethora of recent studies investigating the possibility of damage related to ketamine with normal, pathological (e.g., patients with schizophrenia), and ketamine-abusing volunteers. The majority of these studies suggest that ketamine can be safely used for treatment of various psychological/ psychiatric problems (Morgan, Mofeez, Brandner, Bromley, & Curran, 2004;Karst, Wiese, Emrich, & Schneider, 2005;Cho, D'Souza, Gueorgiuieva, Perry, Madonick, Karper et al, 2005;Parwani,Weiler, Blaxton, Warfel, Hardin, Frey et al, 2005;Holcomb, Medoff, Cullen, & Taminga, 2005;Morgan, Rossell, Pepper, Smart, Blackburn, Brandner et al, 2006).…”