Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model

Wen, Gehua; Zhan, Xiaoni; Xu, Xiaoming; Xia, Xi; Jiang, Shukun; Ren, Xinghua; Ren, Weishu; Lou, Haoyang; Lu, Lei; Hermenean, Anca; Yao, Jun; Gao, Lina; Li, Baoman; Lu, Yan; Wu, Xu

doi:10.1007/s12035-023-03669-1

Mol Neurobiol

2023

DOI: 10.1007/s12035-023-03669-1

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Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model

Gehua Wen,

Xiaoni Zhan,

Xiaoming Xu

et al.

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Cited by 3 publications

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Biomedicine & Pharmacotherapy

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Ketamine administration causes cognitive impairment by destroying the circulation function of the glymphatic system

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Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential

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Depression represents a prevalent and enduring mental disorder of significant concern within the clinical domain. Extensive research indicates that depression is very complex, with many interconnected pathways involved. Most research related to depression focuses on monoamines, neurotrophic factors, the hypothalamicpituitary-adrenal axis, tryptophan metabolism, energy metabolism, mitochondrial function, the gut-brain axis, glial cell-mediated inflammation, myelination, homeostasis, and brain neural networks. However, recently, Ketamine, an ionotropic N-methyl-D-aspartate (NMDA) receptor antagonist, has been discovered to have rapid antidepressant effects in patients, leading to novel and successful treatment approaches for mood disorders. This review aims to summarize the latest findings and insights into various signaling pathways and systems observed in depression patients and animal models, providing a more comprehensive view of the neurobiology of anxious-depressive-like behavior. Specifically, it highlights the key mechanisms of ketamine as a rapid-acting antidepressant, aiming to enhance the treatment of neuropsychiatric disorders. Moreover, we discuss the potential of ketamine as a prophylactic or therapeutic intervention for stress-related psychiatric disorders.

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Ketamine Improves the Glymphatic Pathway by Reducing the Pyroptosis of Hippocampal Astrocytes in the Chronic Unpredictable Mild Stress Model

Cited by 3 publications

References 42 publications

Ketamine administration causes cognitive impairment by destroying the circulation function of the glymphatic system

Ketamine administration causes cognitive impairment by destroying the circulation function of the glymphatic system

SARS-CoV-2 N protein induces alveolar epithelial apoptosis via NLRP3 pathway in ARDS

Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential

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