2020
DOI: 10.1371/journal.pone.0236430
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Ketamine-induced neuromuscular reactivity is associated with aging in female rhesus macaques

Abstract: Rhesus macaques represent an important species for translational and pre-clinical research studies across a multitude of disease and injury models, including aging. Ketamine anesthesia is used in humans and non-human primates but may be associated with adverse effects, including neuromuscular reactions. The effects of aging on ketamine adverse effects is not well characterized. Urodynamic recordings and electromyography (EMG) studies were performed in aged (>20 years old) and adult (3.9-14.9 years old) female … Show more

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Cited by 7 publications
(4 citation statements)
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“…In addition to the certification already cited all animal procedures and care were performed in compliance with the Guide for the Care and Use of Laboratory Animals provided by the Institute for Laboratory Animal Research 46 . Guidelines for ARRIVE 2.0 for the care and use of laboratory animals were also followed [47][48][49] .…”
Section: Animal Procedures All Animal Procedures Were Performed At Tmentioning
confidence: 99%
“…In addition to the certification already cited all animal procedures and care were performed in compliance with the Guide for the Care and Use of Laboratory Animals provided by the Institute for Laboratory Animal Research 46 . Guidelines for ARRIVE 2.0 for the care and use of laboratory animals were also followed [47][48][49] .…”
Section: Animal Procedures All Animal Procedures Were Performed At Tmentioning
confidence: 99%
“…The urodynamic studies were performed according to our established procedures for cystometrogram (CMG) recordings in rhesus macaques 27 , 28 . All subjects were first sedated by an intramuscular (IM) injection of ketamine (10 mg/kg) followed by the placement of an intravenous (IV) catheter for the administration of anesthetics and fluid.…”
Section: Methodsmentioning
confidence: 99%
“…Furthermore, other combination such as ketamine/propofol, collectively called “Ketofol”, is used for short procedural sedation ( 12 , 20 ). Propofol is a sedative-hypnotic agent with good sedation and muscle relaxation effects which could address the observed ketamine-induced muscle spasm in rhesus macaques ( 83 ). Ketofol has also been found to reduce adverse respiratory events as compared to propofol treatment alone ( 81 ), as well as demonstrated neuroprotective and anti-inflammatory responses in mice with toxic status epilepticus ( 84 ).…”
Section: Choice Of Sedative Anesthesia and Analgesiamentioning
confidence: 99%