Ketamine inhibits synaptic transmission and nicotinic acetylcholine receptor-mediated responses in rat intracardiac ganglia in situ

Abstract

Highlights: Ketamine attenuated the excitatory postsynaptic responses evoked by nerve stimulation in a concentration-dependent manner. This reduction was significant at clinically relevant concentrations at high frequencies. Ketamine inhibits nicotinic acetylcholine receptor-mediated currents in dissociated rat intracardiac ganglion (ICG) neurons. Ketamine inhibits cholinergic synaptic transmission in the rat ICG accounting for attenuation of vagal bradycardia.

The role of nitric oxide on the antiarrhythmic effects of ketamine/xylazine in a rat model of acute cardiac ischemia-reperfusion

“…One mechanism is that acetylcholine canals neuronal in the intra-cardiac ganglion (nAch) might close, which is typically observed due to thiopental sodium injection as well as ketamine. These channels are responsible for entering Ca 2+ into the heart to initiate depolarization ( Harper et al, 2020 ) Thiopental and ketamine act as an ATP-associated potassium channels inhibitor in cardiomyocytes, which reduce the protective effects of diazoxide, a potassium channel activator ( Zaugg et al, 2002 ). In contrast, combining xylazine as an α-agonist with ketamine eliminates the ketamine-related myocardial suppression effects.…”

The Acute Effects and Mechanism of Ketamine on Nicotine-Induced Neurogenic Relaxation of the Corpus Cavernosum in Mice

“…Erectile dysfunction (ED) has been observed in male ketamine abusers [ 30 , 31 ] and in ketamine-treated animals [ 32 , 33 ]. Chen MF et al found that ketamine acutely blocked the nAChRs on cerebral perivascular sympathetic nerves, which then reduced nicotine-induced neurogenic vasodilation [ 34 , 35 ]. However, the acute effects of ketamine on penile erections are unknown.…”