Ketamine promotes adaption-induced orientation plasticity and vigorous network changes

Ouelhazi, Afef; Lussiez, Rudy; Molotchnikoff, Stéphane

doi:10.1016/j.brainres.2022.148111

Cited by 4 publications

(6 citation statements)

References 98 publications

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“…In line with this, studies in healthy individuals or animals have shown that selective D2 receptor antagonists may change the amplitudes of event-related potentials in the auditory 86 and visual systems 87 . D2R antagonism has been shown to affect spatial working memory and planning in humans 88 , 89 , executive function in primates 90 , visuo-cognitive 87 , and cognitive processes 86 . Future studies investigating the role of dopamine D2 receptor (D2R) blockade in healthy controls would help further elucidate the precise role of antipsychotic medication in spatial frequency sensitivity.…”

Section: Discussionmentioning

confidence: 99%

A neural modeling approach to study mechanisms underlying the heterogeneity of visual spatial frequency sensitivity in schizophrenia

Dugan,

Zikopoulos,

Yazdanbakhsh

2024

Schizophr

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Patients with schizophrenia exhibit abnormalities in spatial frequency sensitivity, and it is believed that these abnormalities indicate more widespread dysfunction and dysregulation of bottom-up processing. The early visual system, including the first-order Lateral Geniculate Nucleus of the thalamus (LGN) and the primary visual cortex (V1), are key contributors to spatial frequency sensitivity. Medicated and unmedicated patients with schizophrenia exhibit contrasting changes in spatial frequency sensitivity, thus making it a useful probe for examining potential effects of the disorder and antipsychotic medications in neural processing. We constructed a parameterized, rate-based neural model of on-center/off-surround neurons in the early visual system to investigate the impacts of changes to the excitatory and inhibitory receptive field subfields. By incorporating changes in both the excitatory and inhibitory subfields that are associated with pathophysiological findings in schizophrenia, the model successfully replicated perceptual data from behavioral/functional studies involving medicated and unmedicated patients. Among several plausible mechanisms, our results highlight the dampening of excitation and/or increase in the spread and strength of the inhibitory subfield in medicated patients and the contrasting decreased spread and strength of inhibition in unmedicated patients. Given that the model was successful at replicating results from perceptual data under a variety of conditions, these elements of the receptive field may be useful markers for the imbalances seen in patients with schizophrenia.

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Section: Discussionmentioning

confidence: 99%

A neural modeling approach to study mechanisms underlying the heterogeneity of visual spatial frequency sensitivity in schizophrenia

Dugan,

Zikopoulos,

Yazdanbakhsh

2024

Schizophr

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“…1B ). Action potentials were sorted from the multi-unit signal using the spike sorting method and further confirmed by cluster analysis (Afef et al, 2022; Bharmauria et al, 2016a; Chanauria et al, 2019). The stability of each cell’s response across conditions was verified qualitatively by visual control of the cluster disposition and of the waveform shape.…”

Section: Methodsmentioning

confidence: 99%

“…What are the effects of the visual adaptation on mouse visual neurons and how does new selectivity emerge post-adaptation? Here, using a 12-min uninterrupted adaptation protocol (Afef et al, 2022; Bachatene et al, 2015b; Jeyabalaratnam et al, 2013) on mouse visual neurons, we examined the above questions. We report that adaptation further sharpens the selectivity of mouse visual neurons, suggesting emergence of novel circuits through changed excitation/inhibition balance.…”

Section: Introductionmentioning

confidence: 99%

Adaptation-induced sharpening of orientation tuning curves in the mouse visual cortex

Ouelhazi,

Bharmauria,

Molotchnikoff

2023

Preprint

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Orientation selectivity is an emergent property of visual neurons across species with columnar and non-columnar organization of the visual cortex. To compute the orientation selectivity of a neuron, a tuning function is fit on the raw responses of a neuron and then a measure, termed orientation selectivity index (OSI), is derived from this fitted curve to determine the tuning of the neuron. Previously, it has been shown that adaptation (a protocol where a neuron under observation is presented a non-optimal stimulus for a specific time) has varying effects on the tuning properties of neurons, such as, orientation, spatial frequency, motion etc. The emergence of OSI is more established in columnar cortices than the non-columnar ones. However, how adaptation impinges upon the OSI of the latter has not been systematically investigated. Here, in the mouse primary visual cortex (V1), we show that a 12-min adaptation protocol sharpens the OSI (tuning) of the visual neurons, underlying a specific dendritic neural mechanism, potentially facilitating the learning of novel features.

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“…1b). Action potentials were sorted from the multi-unit signal using the spike sorting method and further confirmed by cluster analysis [38][39][40][41]. The stability of each cell's response across conditions was verified qualitatively by visual control of the cluster disposition and of the waveform shape.…”

Section: Monocular Stimulationmentioning

confidence: 99%

“…What are the effects of the visual adaptation on mouse visual neurons, and how does the new selectivity emerge post-adaptation? Here, using a 12-min uninterrupted adaptation protocol [13,37,38] on mouse visual neurons, we examined the above questions. We report that adaptation further sharpens the selectivity of mouse visual neurons, suggesting the emergence of novel circuits through changed excitation/inhibition balance.…”

Section: Introductionmentioning

confidence: 99%

Adaptation-induced sharpening of orientation tuning curves in the mouse visual cortex

Ouelhazi,

Bharmauria,

Molotchnikoff

2024

NeuroReport

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Objective Orientation selectivity is an emergent property of visual neurons across species with columnar and noncolumnar organization of the visual cortex. The emergence of orientation selectivity is more established in columnar cortical areas than in noncolumnar ones. Thus, how does orientation selectivity emerge in noncolumnar cortical areas after an adaptation protocol? Adaptation refers to the constant presentation of a nonoptimal stimulus (adapter) to a neuron under observation for a specific time. Previously, it had been shown that adaptation has varying effects on the tuning properties of neurons, such as orientation, spatial frequency, motion and so on. Basic methods We recorded the mouse primary visual neurons (V1) at different orientations in the control (preadaptation) condition. This was followed by adapting neurons uninterruptedly for 12 min and then recording the same neurons postadaptation. An orientation selectivity index (OSI) for neurons was computed to compare them pre- and post-adaptation. Main results: We show that 12-min adaptation increases the OSI of visual neurons (n = 113), that is, sharpens their tuning. Moreover, the OSI postadaptation increases linearly as a function of the OSI preadaptation. Conclusion The increased OSI postadaptation may result from a specific dendritic neural mechanism, potentially facilitating the rapid learning of novel features.

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Ketamine promotes adaption-induced orientation plasticity and vigorous network changes

Cited by 4 publications

References 98 publications

A neural modeling approach to study mechanisms underlying the heterogeneity of visual spatial frequency sensitivity in schizophrenia

A neural modeling approach to study mechanisms underlying the heterogeneity of visual spatial frequency sensitivity in schizophrenia

Adaptation-induced sharpening of orientation tuning curves in the mouse visual cortex

Adaptation-induced sharpening of orientation tuning curves in the mouse visual cortex

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