Ketamine treatment protects against oxidative damage and the immunological response induced by electroconvulsive therapy

Gonçalves, Cinara L.; Abelaira, Helena M.; Rosa, Thayse; Moura, Airam B. de; Veron, Deise Cristina; Borba, Laura A.; Botelho, Maria Eduarda M.; Garbossa, Leandro; Fileti, Maria Eduarda; Petronilho, Fabrícia; Ignácio, Zuleide Maria; Quevedo, João; Réus, Gislaine Z.

doi:10.1007/s43440-020-00200-4

Cited by 7 publications

(8 citation statements)

References 59 publications

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“…One study found decreased 43 and three studies found increased 44 ,46, 47 or no alteration 45 , 48 levels of SOD. Catalase levels were evaluated in 3 studies 44 ,45, 48 and CAT levels were increased in a study. 44 Whereas 2 studies did not report any change in CAT levels after treatment with ECS.…”

Section: Resultsmentioning

confidence: 96%

“…Superoxide dismutase was assessed in 6 studies. 43 - 48 Samples were collected from various tissues such as the frontal cortex, hippocampus, striatum, and cerebellum in these studies. One study found decreased 43 and three studies found increased 44 ,46, 47 or no alteration 45 , 48 levels of SOD.…”

Section: Resultsmentioning

confidence: 99%

“… 43 - 48 Samples were collected from various tissues such as the frontal cortex, hippocampus, striatum, and cerebellum in these studies. One study found decreased 43 and three studies found increased 44 ,46, 47 or no alteration 45 , 48 levels of SOD. Catalase levels were evaluated in 3 studies 44 ,45, 48 and CAT levels were increased in a study.…”

Section: Resultsmentioning

confidence: 99%

“… 43 , 47 Erakovic et al 43 found increased levels of GSH, whereas Zahedi et al 47 found decreased levels of GSH. NO was assessed in 3 studies and the studies reported increased levels of nitrite 47 and nitrate levels 48 and decreased levels of nitrite. 31…”

Section: Resultsmentioning

confidence: 99%

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A Systematic Review of the Literature Regarding the Relationship Between Oxidative Stress and Electroconvulsive Therapy

Atagün¹,

Canbek²

2022

ALPHA PSYCHIATRY

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Objective Brain’s aerobic energy metabolism, abundance of the fatty acids and unsaturated lipids, generation of Reactive Oxygen Species (ROS) by hormones, physiological roles of transition metals (i.e., iron and copper), and free radicals in the nervous system may cause inclination to oxidative stress in psychiatric disorders. Electroconvulsive therapy (ECT) may cause oxidative stress by the electrical field or by the induced seizure. It was aimed to review the literature in terms of the influence of ECT on levels of oxidant and antioxidant compounds. Methods The literature search was performed with the keywords that were oxidative stress or "DNA damage" or "RNA damage" or "lipid peroxidase" or "superoxide dismutase" or "catalase" or "glutathione" or "nitrite" or "nitric oxide" and "electroconvulsive therapy" or "electroconvulsive shock" or "electroconvulsive seizure". Twenty of 1480 records were included. Results Eleven studies were performed in human subjects, whereas 9 studies were performed in rats. Human studies are conducted with serum, plasma, or urine samples; rat studies include brain tissues from various sites. In rats, four independent studies showed increased levels of lipid oxidation markers, and four independent studies reported increased levels of oxidative stress markers in brain samples. In human studies, studies were performed with circulating blood samples and the results were more inconsistent. Conclusion Although some markers like superoxide dismutase or thioredoxin imply that ECT may increase the balance for oxidative stress, this notion is not supported by other markers of ECT. The current literature does not clearly suggest that the ECT is associated with oxidative stress in psychiatric disorders. Further studies with similar methods should be performed in big samples.

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Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

A Systematic Review of the Literature Regarding the Relationship Between Oxidative Stress and Electroconvulsive Therapy

Atagün¹,

Canbek²

2022

ALPHA PSYCHIATRY

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“…Importantly, pre-clinical studies have shown that pre-treatment with another NMDA receptor antagonist, MK-801, can block hypoglycemia-induced apoptosis of neurons ( Tasker et al, 1992 , Wieloch, 1985 ). As well, pre-treating rodents with ketamine induces prophylaxis against future stressors ( Amat et al, 2016 , Brachman et al, 2016 ); and, lowers blood ( Gonçalves et al, 2021 , Zhan et al, 2020 ) and central ( Zhang et al, 2016 ) levels of pro-inflammatory cytokines ( Mastrodonato et al, 2020 , Walker et al, 2015 ). Finally, ketamine also reverses depressive-like behaviors induced by hypoglycemic and psychophysical stressors ( Melanson et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Effect of ketamine on the physiological responses to combined hypoglycemic and psychophysical stress

Melanson

Leri

2021

IBRO Neuroscience Reports

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There is evidence that hypoglycemic stress can interact with other stressors, and that ketamine can mitigate the impact of these stressors on behavior and physiology. The current study in male Sprague-Dawley rats investigated whether pre-treatment with 0, 10, or 20 mg/kg ketamine could modulate the interaction between hypoglycemia induced by 0 or 300 mg/kg 2-deoxy- D -glucose (2-DG) and the psychophysical stress of forced swimming (FSS; 6 sessions, 10 min/session) on serum concentrations of corticosterone (CORT) and the pro-inflammatory cytokine, tumor necrosis factor (TNF)-α. It was found that 2-DG enhanced the CORT response to an initial session of FSS, and this effect dissipated after multiple sessions. More importantly, animals displayed significantly higher levels of CORT and lower levels of TNF-α in response to a drug-free test swim conducted 1 week after exposure to the combined stressors, and these responses were not observed in rats that were pre-treated with ketamine. Overall, these findings indicate that ketamine has the potential to reduce the negative impact of interacting stressors on the biological reactivity of the hypothalamic-pituitary-adrenal axis and the immune system.

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Role of Glutamatergic Neurotransmission in the Pathophysiology of Stress-Related Disorders and Chronic Stress Response

Réus¹,

Abelaira²,

Coutellier

et al. 2022

Glutamate and Neuropsychiatric Disorders

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Ketamine treatment protects against oxidative damage and the immunological response induced by electroconvulsive therapy

Cited by 7 publications

References 59 publications

A Systematic Review of the Literature Regarding the Relationship Between Oxidative Stress and Electroconvulsive Therapy

A Systematic Review of the Literature Regarding the Relationship Between Oxidative Stress and Electroconvulsive Therapy

Effect of ketamine on the physiological responses to combined hypoglycemic and psychophysical stress

Role of Glutamatergic Neurotransmission in the Pathophysiology of Stress-Related Disorders and Chronic Stress Response

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