Ketoacids

Smith, Ivan K.; Smith, M. J. H.

doi:10.1016/b978-0-433-30503-3.50021-3

Chromatography 1969

DOI: 10.1016/b978-0-433-30503-3.50021-3

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Ketoacids

Ivan K. Smith¹,

M. J. H. Smith²

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1970

1979

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Cited by 3 publications

(2 citation statements)

References 16 publications

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“…In both sexes, no increase over controls was found in the first three broods of two days each; after this, the translocation frequency in both sexes increased, at first slightly and then steeply, reaching a peak in the last broad, sampled 12 to 14 days after treatment. Similar results were obtained for dominant versus recessive lethals in Habrobracon (SMITH 1969).…”

supporting

confidence: 84%

THE BROOD PATTERN OF MITOMYCIN-C-INDUCED TRANSLOCATIONS IN DROSOPHILA MELANOGASTER MALES: THE EFFECT OF TIME

Shukla¹,

Auerbach²

1979

Genetics

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supporting

confidence: 84%

THE BROOD PATTERN OF MITOMYCIN-C-INDUCED TRANSLOCATIONS IN DROSOPHILA MELANOGASTER MALES: THE EFFECT OF TIME

Shukla¹,

Auerbach²

1979

Genetics

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“…The evidence further suggests that this machinery becomes operative in response to specific physiological stimuli mediated through the sympathetic nervous system [2].…”

mentioning

confidence: 93%

Conditions in vitro which Affect Respiratory Control and Capacity for Respiration‐Linked Phosphorylation in Brown Adipose Tissue Mitochondria

Grav

Pedersen

Christiansen

1970

European Journal of Biochemistry

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Oxidative phosphorylation in brown adipose tissue mitochondria is greatly influenced by variations in the in vitro environment. Factors found to be of particular importance were the concentrations of serum albumin, of magnesium and EDTA, and the osmolality and the pH of the medium. The maximal P/O ratios obtained in an isoosmolar medium at pH 6.3, containing 2O//, serum albumin, 7.5 mM MgCl,, and 7.5 mM EDTA with pyruvate-malate as substrate, and using the glucose-hexokinase trapping system, were 2.8 for newborn guinea-pigs and 2.6 for unweaned rats.Under otherwise equal conditions the P/O ratios obtained with 4-week-old guinea-pigs were higher than those with the newborn.EDTA was a requirement for demonstration of respiratory control in brown adipose tissue mitochondria. Respiration with pyruvate-malate or succinate (+ rotenone), and stimulated by inorganic phosphate and ADP, was found to be sensitive to oligomycin and to carbonyl cyanide phenylhydrazone. However, the small extent of stimulation by the phosphate acceptor system, the incomplete inhibition by oligomycin, and the fact that the respiratory rate after exhaustion of added ADP was higher than that prior to the addition of ADP, suggest that brown adipose tissue mitochondria are loosely coupled.The measured respiratory control ratios all increased from the newborn to the 3-week-old guinea-pigs.Mitochondria from newborn and 6-day-old guinea-pigs exhibited the phenomenon of "reversed acceptor control". Thus, in the absence of added inorganic phosphate, ADP inhibited the respiration with pyruvate-malate or with succinate. The reversed ADP control was abolished by carbonyl cyanide phenylhydrazone, but was not suppressed by treatment of the mitochondria with oligomy&.Inorganic phosphate affects respiration in a composite manner. With all of the preparations tested, inorganic phosphate stimulated respiration whether exogenous ADP was present or not.

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D-Methionine Utilization During Parenteral Nutrition in Adult Rats

Cho¹,

Stegink²

1979

The Journal of Nutrition

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D-Methionine, present in some parenteral solutions, is poorly utilized by man. To evaluate some of the factors affecting utilization, methionine isomer excretion was measured in rats treated with two different parenteral regimens: total parenteral nutrition and protein sparing therapy. Within each regimen, nutrient solutions differing only in methionine isomer composition were compared. Eight rats on the total parenteral nutrition regimen were infused with a 33% glucose--2.8% amino acid solution at a rate providing 100% of energy requirement. Four rats received the parenteral sulution containing L-methionine, and four the solution containing DL-methionine. Eight additional rats on a protein sparing regimen were infused with an amino acid solution (8.5%) at a rate to provide 25% of energy requirement. Four rats were infused with a solution containing L-methionine, and four with a solution containing DL-methionine. Total methionine content of livers was not affected by differences in methionine isomer. Infusion of the solution containing DL-methionine significantly increased plasma methionine levels during protein sparing therapy, with the increase representing accumulation of the D-isomer. Rats receiving protein sparing therapy had significantly higher liver methionine levels than rats receiving total parenteral nutrition. Although rats infused with the solution containing DL-methionine had elevated plasma methionine levels during protein sparing therapy, urinary methionine losses were small, as were losses of methionine sulfoxide and alpha-keto-gamma-methiolbutyrate. In contrast to humans, adult rats utilized more than 99% of parenterally administered D- or L-methionine.

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Ketoacids

Cited by 3 publications

References 16 publications

THE BROOD PATTERN OF MITOMYCIN-C-INDUCED TRANSLOCATIONS IN DROSOPHILA MELANOGASTER MALES: THE EFFECT OF TIME

THE BROOD PATTERN OF MITOMYCIN-C-INDUCED TRANSLOCATIONS IN DROSOPHILA MELANOGASTER MALES: THE EFFECT OF TIME

Conditions in vitro which Affect Respiratory Control and Capacity for Respiration‐Linked Phosphorylation in Brown Adipose Tissue Mitochondria

D-Methionine Utilization During Parenteral Nutrition in Adult Rats

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