Ketogenic diet efficacy in children with Lennox–Gastaut Syndrome

Nickels, Katherine; Kenney, Daniel L.; Eckert, Susan; Wong‐Kisiel, Lily C.; Wirrell, Elaine

doi:10.1016/j.jns.2013.07.057

Cited by 1 publication

(9 citation statements)

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“…Most individuals with LGS receive ASMs to manage their symptoms 23,26,28,30,34,36,42,53,55,60,69,78,80,82,83,88,91,95–100 . Across 23 studies with information on LGS treatment, 19 reported that all individuals with LGS received ASMs, and the other four studies generally found that more than 80% of individuals used ASMs.…”

Section: Resultsmentioning

confidence: 99%

“…For corpus callosotomy, two studies reported AEs, which related to brain connections (e.g., acute disconnection syndrome, aphasia, ataxia, and paresis) 28,111 . AEs related to dietary therapy were reported in two studies, and were mainly gastrointestinal, including vomiting, diarrhea, constipation, and weight loss, as well as metabolic acidosis 56,96 …”

Section: Resultsmentioning

confidence: 99%

“…28,111 AEs related to dietary therapy were reported in two studies, and were mainly gastrointestinal, including vomiting, diarrhea, constipation, and weight loss, as well as metabolic acidosis. 56,96…”

Section: Treatment Burdenmentioning

confidence: 99%

“…Most individuals with LGS receive ASMs to manage their symptoms. 23,26,28,30,34,36,42,53,55,60,69,78,80,82,83,88,91,[95][96][97][98][99][100] Across 23 studies with information on LGS treatment, 19 reported that all individuals with LGS received ASMs, and the other four studies generally found that more than 80% of individuals used ASMs. However, pharmacoresistance associated with switching of ASMs 21,23,34,36,39,41,45,49,50,72,73,77,85,92,93,95,96,[101][102][103][104] and polytherapy 51,105 was common.…”

Section: Treatment Burdenmentioning

confidence: 99%

“…23,26,28,30,34,36,42,53,55,60,69,78,80,82,83,88,91,[95][96][97][98][99][100] Across 23 studies with information on LGS treatment, 19 reported that all individuals with LGS received ASMs, and the other four studies generally found that more than 80% of individuals used ASMs. However, pharmacoresistance associated with switching of ASMs 21,23,34,36,39,41,45,49,50,72,73,77,85,92,93,95,96,[101][102][103][104] and polytherapy 51,105 was common. These findings were consistent for children and adults across several countries, suggesting no difference by demographic or individual characteristics.…”

Section: Treatment Burdenmentioning

confidence: 99%

See 4 more Smart Citations

A comprehensive systematic literature review of the burden of illness of Lennox–Gastaut syndrome on patients, caregivers, and society

Cross,

Benítez,

Roth

et al. 2024

Epilepsia

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Fully elucidating the burden that Lennox–Gastaut syndrome (LGS) places on individuals with the disease and their caregivers is critical to improving outcomes and quality of life (QoL). This systematic literature review evaluated the global burden of illness of LGS, including clinical symptom burden, care requirements, QoL, comorbidities, caregiver burden, economic burden, and treatment burden (PROSPERO ID: CRD42022317413). MEDLINE, Embase, and the Cochrane Library were searched for articles that met predetermined criteria. After screening 1442 deduplicated articles and supplementary manual searches, 113 articles were included for review. A high clinical symptom burden of LGS was identified, with high seizure frequency and nonseizure symptoms (including developmental delay and intellectual disability) leading to low QoL and substantial care requirements for individuals with LGS, with the latter including daily function assistance for mobility, eating, and toileting. Multiple comorbidities were identified, with intellectual disorders having the highest prevalence. Although based on few studies, a high caregiver burden was also identified, which was associated with physical problems (including fatigue and sleep disturbances), social isolation, poor mental health, and financial difficulties. Most economic analyses focused on the high direct costs of LGS, which arose predominantly from medically treated seizure events, inpatient costs, and medication requirements. Pharmacoresistance was common, and many individuals required polytherapy and treatment changes over time. Few studies focused on the humanistic burden. Quality concerns were noted for sample representativeness, disease and outcome measures, and reporting clarity. In summary, a high burden of LGS on individuals, caregivers, and health care systems was identified, which may be alleviated by reducing the clinical symptom burden. These findings highlight the need for a greater understanding of and better definitions for the broad spectrum of LGS symptoms and development of treatments to alleviate nonseizure symptoms.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%