Ketogenic diet in patients with epileptic encephalopathy with electrical status epilepticus during slow sleep

Reyes, Gabriela; Flesler, Santiago; Armeno, Marisa; Fortini, Sebastián; Agustinho, Ariela; Cresta, Araceli; Mestre, Graciela; Caraballo, Roberto

doi:10.1016/j.eplepsyres.2015.03.017

Cited by 26 publications

(17 citation statements)

References 25 publications

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“…Among the latter, the two patients with unilateral polymicrogyria had the best response with >50% seizure reduction. This is congruent with the study of Reyes et al [8] where KD was used effectively in ESES with structural etiology.…”

Section: Discussionsupporting

confidence: 92%

Ketogenic diet use in children with intractable epilepsy secondary to malformations of cortical development: A two- centre experience

Pasca

Caraballo

Giorgis

et al. 2018

Seizure

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Section: Discussionsupporting

confidence: 92%

Ketogenic diet use in children with intractable epilepsy secondary to malformations of cortical development: A two- centre experience

Pasca

Caraballo

Giorgis

et al. 2018

Seizure

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“…We think that KD should be considered in the management of children with ESES syndrome, be they symptomatic or idiopathic. 42 We reported one case of status of the Gastaut type of ICOE in which the patient only responded to IVIG. 37,38 Several cases of successful use of IVIG in LKS cases were also reported.…”

Section: Proposed Scheme Of Treatmentmentioning

confidence: 92%

“…Neuropsychological improvement was seen in the children with good responses. 42 • Surgery: Multiple subpial transection (MST) is the surgical procedure applied for the treatment of language regression on LKS. 43 MST of the cortex to abolish epileptic discharges was used in a series of 14 children with acquired epileptic aphasia who had been unable to use language to communicate for at least 2 years; sustained improvement was obtained in 11 of them.…”

Section: Treatment Options For Atypical Evolutions Of Ifecmentioning

confidence: 99%

Treatment of Atypical Evolutions of Idiopathic Focal Epilepsies in Childhood

2016

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The relationship between continuous spike-and-wave discharges during slow sleep (CSWSS) and neuropsychological impairment (cognitive functions, memory consolidation, and language and behavior disturbances) has been clearly demonstrated. These phenomena occur not only in symptomatic cases of CSWSS or electrical status epilepticus in sleep (ESES) syndrome, but also in the different conditions that constitute the spectrum of atypical evolutions of idiopathic focal epilepsies of childhood (IFEC). In spite of continuous advances in treatment, management is still difficult and challenging. Treatment options of atypical evolutions of IFEC include benzodiazepines, sulthiame, levetiracetam, valproic acid, and ethosuximide. Other drugs such as lacosamide and acetazolamide have been proposed. Usual antiepileptic drugs such as carbamazepine, phenobarbital, phenytoin, oxcarbazepine, lamotrigine, and topiramate were proven to be capable of inducing ESES. Steroids and intravenous immunoglobulins were recommended in refractory cases. Surgery, ketogenic diet, and vagal nerve stimulation were also used in some cases. Our interest regarding a scheme of treatment in atypical evolutions of IFEC is centered on two questions: (1) Is it possible to prevent the evolution of IFEC into atypical focal epilepsies of childhood, status epilepticus of IFEC, Landau–Kleffner's syndrome, or ESES syndrome? (2) Which is the treatment of choice once one of these conditions is installed?

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“…Of the patients, 61% were considered responders, but only one was able to discontinue steroids during follow-up. In a series by Reyes et al (2015), 12 patients with ESES were treated with the ketogenic diet for a minimum of 18 months. At the end of follow-up, seven patients remained on the diet, one patient became seizure-free, and three had a significant improvement in seizure reduction.…”

Section: Ketogenic Dietmentioning

confidence: 99%

Current treatment options for Encephalopathy related to Status Epilepticus during slow Sleep

Jansen¹,

Nikanorova

Peltola

2019

Epileptic Disorders

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The major goal of therapy in patients with Encephalopathy related to Status Epilepticus during slow Sleep (ESES) is to prevent or reduce associated cognitive deficits. Whether or not the EEG pattern of ESES should be completely suppressed to improve cognition is unknown. In clinical practice, there are two major challenges: to establish the optimal treatment strategy in patients with ESES, and to identify the patients who will benefit most from therapy, including atypical cases. Here, we provide a comprehensive overview of the current literature on treatment efficacy in patients with ESES.

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Ketogenic diet in patients with epileptic encephalopathy with electrical status epilepticus during slow sleep

Cited by 26 publications

References 25 publications

Ketogenic diet use in children with intractable epilepsy secondary to malformations of cortical development: A two- centre experience

Ketogenic diet use in children with intractable epilepsy secondary to malformations of cortical development: A two- centre experience

Treatment of Atypical Evolutions of Idiopathic Focal Epilepsies in Childhood

Current treatment options for Encephalopathy related to Status Epilepticus during slow Sleep

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