Ketogenic diet in pediatric epilepsy patients with gastrostomy feeding

Hosain, Syed; Vega‐Talbott, Maite La; Solomon, Gail E.

doi:10.1016/j.pediatrneurol.2004.09.006

Cited by 67 publications

(53 citation statements)

References 11 publications

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“…27,28 Greater rates of seizure response have also been reported in formula feeding as compared to solid meals (59% vs. 27%, at 12 months of treatment). Previous studies have recommended using an all-liquid KD to facilitate compliance, ensure sufficient ketosis, and minimize certain side effects such as acidosis and dehydration.…”

Section: Discussionmentioning

confidence: 99%

Use of the ketogenic diet to manage refractory epilepsy in CDKL5 disorder: Experience of >100 patients

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Use of the ketogenic diet to manage refractory epilepsy in CDKL5 disorder: Experience of >100 patients

et al. 2017

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“…Interestingly, success of the KD in this cohort may be due in part to an infant's primary dependency on an all-liquid KD. Studies that have evaluated formula-based administration, whether fed via bottle or gastrostomy tube, indicate better compliance and ultimately better seizure control compared with the typical solid-food diet [15,16]. In recent years, many KD centers have found that dependency on gastrostomy tubes, regardless of age, may represent a special indication for the KD in patients with otherwise intractable seizures or intolerable side effects to anticonvulsant drugs.…”

Section: Indicationsmentioning

confidence: 99%

State of the ketogenic diet(s) in epilepsy

Huffman¹,

Kossoff

2006

Curr Neurol Neurosci Rep

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Fasting has been recognized as a treatment for seizures since ancient times. The ketogenic diet is a low-carbohydrate, adequate-protein, high-fat diet that biochemically mimics the fasting state and has been used to successfully treat seizures for 85 years. The diet has enjoyed a resurgence in popularity over the past decade and is gaining acceptance and use worldwide. Many studies over the past several years have explored possible mechanisms of action for the ketogenic diet. This review addresses these studies, as well as recent research regarding possible indications for the diet, variations in its initiation, side effect profiles, and the recent use of modified formulations to improve tolerability.

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“…Two studies suggest that formula-only ketogenic diets could have improved efficacy over a solid-food ketogenic diet. 16,17 We hypothesized that supplementing the modified Atkins diet with a daily ketogenic formula (KetoCal 1 ) would lead to improved seizure control and tolerability, possibly due to increased ketosis. Our secondary hypothesis was that achieved seizure reduction would be maintained during the second month, even after KetoCal 1 was discontinued, thus confirming that early restrictiveness is only necessary temporarily.…”

mentioning

confidence: 99%

Prospective Study of the Modified Atkins Diet in Combination With a Ketogenic Liquid Supplement During the Initial Month

et al. 2010

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The modified Atkins diet is a high-fat, low-carbohydrate treatment for intractable childhood epilepsy. As data suggest that a stricter diet onset can be more effective, we added a ketogenic supplement to the modified Atkins diet during its initial month. Thirty children with intractable epilepsy were prospectively started on the modified Atkins diet in combination with a daily 400-calorie KetoCal shake. At 1 month, 24 (80%) children had >50% seizure reduction, of which 11 (37%) had >90% seizure reduction. There was no significant loss of efficacy during the second month after KetoCal was discontinued. The use of this ketogenic supplement increased daily fat intake and thus the ketogenic ratio (1.8:1 versus 1.0:1 in the modified Atkins diet alone, P = .0002), but did not change urinary or serum ketosis. The addition of a ketogenic supplement to the modified Atkins diet during its initial month appears to be beneficial.

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Ketogenic diet in pediatric epilepsy patients with gastrostomy feeding

Cited by 67 publications

References 11 publications

Use of the ketogenic diet to manage refractory epilepsy in CDKL5 disorder: Experience of >100 patients

Use of the ketogenic diet to manage refractory epilepsy in CDKL5 disorder: Experience of >100 patients

State of the ketogenic diet(s) in epilepsy

Prospective Study of the Modified Atkins Diet in Combination With a Ketogenic Liquid Supplement During the Initial Month

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