Abstract:Sugar bingeing has been shown to induce withdrawal effects when no longer available in the diet. In this study, we investigated the sex differences and effects of the ketogenic diet on sugar-addiction-like behaviour. We used the two-bottle sucrose choice paradigm as a pre-clinical sucrose overeating and withdrawal model. Female mice consumed more sucrose than males when given free access to water and 10% sucrose for four weeks. One week of sucrose withdrawal after four weeks of consecutive sucrose overeating s… Show more
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