Ketone bodies in right ventricular failure: A unique therapeutic opportunity

Blake, Madelyn; Puchalska, Patrycja; Kazmirczak, Felipe; Blake, Jeffrey; Moon, Ryan; Thenappan, Thenappan; Crawford, Peter A.; Prins, Kurt W.

doi:10.1016/j.heliyon.2023.e22227

Heliyon

2023

DOI: 10.1016/j.heliyon.2023.e22227

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Ketone bodies in right ventricular failure: A unique therapeutic opportunity

Madelyn Blake,

Patrycja Puchalska,

Felipe Kazmirczak

et al.

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2024

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Cited by 5 publications

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Noninvasive assessment of liver stiffness in right heart failure: A new phenotype requiring further exploration

Patterson,

Prins

2024

The Journal of Heart and Lung Transplantation

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Noninvasive assessment of liver stiffness in right heart failure: A new phenotype requiring further exploration

Patterson,

Prins

2024

The Journal of Heart and Lung Transplantation

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Extrapulmonary manifestations of pulmonary arterial hypertension

Singh,

Al-Naamani,

Brown

et al. 2024

Expert Review of Respiratory Medicine

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Emerging roles of ketone bodies in cardiac fibrosis

Maduray,

Zhong

2024

American Journal of Physiology-Cell Physiology

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Cardiac fibrosis, characterized by excessive extracellular matrix (ECM) deposition within the myocardium, poses a significant challenge in cardiovascular health, contributing to various cardiac pathologies. Ketone bodies (KBs), particularly β-hydroxybutyrate (β-OHB), have emerged as subjects of interest due to their potential cardioprotective effects. However, their specific influence on cardiac fibrosis remains underexplored. This literature review comprehensively examines the relationship between KBs and cardiac fibrosis, elucidating potential mechanisms through which KBs modulate fibrotic pathways. A multifaceted interplay exists between KBs and key mediators of cardiac fibrosis. While some studies indicate a pro-fibrotic role for KBs, others highlight their potential to attenuate fibrosis and cardiac remodeling. Mechanistically, KBs may regulate fibrotic pathways through modulation of cellular components such as cardiac fibroblasts, macrophages, and lymphocytes, as well as extracellular matrix proteins. Furthermore, the impact of KBs on cellular processes implicated in fibrosis, including oxidative stress, chemokine and cytokine expression, caspase activation, and inflammasome signaling are explored. While conflicting findings exist regarding the effects of KBs on these processes, emerging evidence suggests a predominantly beneficial role in mitigating inflammation and oxidative stress associated with fibrotic remodeling. Overall, this review underscores the importance of elucidating the complex interplay between KB metabolism and cardiac fibrosis. Insights gained have the potential to inform novel therapeutic strategies for managing cardiac fibrosis and associated cardiovascular disorders, highlighting the need for further research in this area.

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Ketone bodies in right ventricular failure: A unique therapeutic opportunity

Cited by 5 publications

References 20 publications

Noninvasive assessment of liver stiffness in right heart failure: A new phenotype requiring further exploration

Noninvasive assessment of liver stiffness in right heart failure: A new phenotype requiring further exploration

Extrapulmonary manifestations of pulmonary arterial hypertension

Emerging roles of ketone bodies in cardiac fibrosis

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