Ketoprofen-loaded rose hip oil nanocapsules attenuate chronic inflammatory response in a pre-clinical trial in mice

Ramos, Priscila Treptow; Pedra, Nathália Stark; Soares, Mayara Sandrielly Pereira; Silveira, Elita Ferreira da; Oliveira, Pathise Souto; Grecco, Fabiane Borelli; Silva, L.M.C. da; Ferreira, Luana Mota; Ribas, Daniele Adriane; Gehrcke, Mailine; Felix, A.; Stefanello, Francieli Moro; Spanevello, Rosélia Maria; Cruz, Letícia; Braganhol, Elizandra

doi:10.1016/j.msec.2019.109742

Cited by 13 publications

(4 citation statements)

References 35 publications

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“…Additionally, nanocapsules can also provide stable fabrication procedures for light-sensitive drugs. Photosensitive drugs such as desonide and ketoprofen have been encapsulated into the oil core of Eudragit ® RL 100 nanocapsules, which was confirmed to enable avoiding drug photodegradation under UV radiation [67,125].…”

Section: Stabilization Under Harsh Environmentmentioning

confidence: 89%

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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Polymer-based nanocapsules have been widely studied as a potential drug delivery system in recent years. Nanocapsules—as one of kind nanoparticle—provide a unique nanostructure, consisting of a liquid/solid core with a polymeric shell. This is of increasing interest in drug delivery applications. In this review, nanocapsules delivery systems studied in last decade are reviewed, along with nanocapsule formulation, characterizations of physical/chemical/biologic properties and applications. Furthermore, the challenges and opportunities of nanocapsules applications are also proposed.

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Section: Stabilization Under Harsh Environmentmentioning

confidence: 89%

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

et al. 2020

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“…Servat-Medina et al (2015) demonstrated that nanoencapsulated crajiru extract required lower doses to achieve similar therapeutic effects compared to the free extract in treating ulcers [ 35 ]. Similarly, Ramos PT et al (2019) developed rosehip oil-loaded ketoprofen nanocapsules (Keto-NC) exhibiting superior anti-inflammatory activity and reduced photo-degradation compared to free ketoprofen, while maintaining non-cytotoxicity in healthy cells [ 36 ]. These studies, along with our findings, highlight the potential of nanoencapsulation for enhancing the therapeutic efficacy and safety of an extract.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulatory and Anticancer Effects of Fridericia chica Extract-Loaded Nanocapsules in Myeloid Leukemia

de Freitas Gomes,

Batalha,

de Castro Alves

et al. 2024

Pharmaceutics

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Nanocapsules provide selective delivery and increase the bioavailability of bioactive compounds. In this study, we examined the anticancer and immunomodulatory potential of Fridericia chica (crajiru) extract encapsulated in nanocapsules targeting myeloid leukemias. Nanocapsules containing crajiru (nanocapsules-CRJ) were prepared via interfacial polymer deposition and solvent displacement. Size and polydispersity were measured by dynamic light scattering. Biological assays were performed on leukemia cell lines HL60 and K562 and on non-cancerous Vero cells and human PBMC. The anticancer activity was evaluated using cytotoxicity and clonogenic assays, while the immunomodulatory activity was evaluated by measuring the levels of pro- and anti-inflammatory cytokines in PBMC supernatants treated with concentrations of nanocapsules-CRJ. Nanocapsules-CRJ exhibited significant cytotoxic activity against HL60 and K562 cells at concentrations ranging from 0.75 to 50 μg/mL, with the greatest reductions in cell viability observed at 50 μg/mL (p < 0.001 for HL60; p < 0.01 for K562), while not affecting non-cancerous Vero cells and human PBMCs. At concentrations of 25 μg/mL and 50 μg/mL, nanocapsules-CRJ reduced the formation of HL60 and K562 colonies by more than 90% (p < 0.0001). Additionally, at a concentration of 12 μg/mL, nanocapsules-CRJ induced the production of the cytokines IL-6 (p = 0.0002), IL-10 (p = 0.0005), IL-12 (p = 0.001), and TNF-α (p = 0.005), indicating their immunomodulatory potential. These findings suggest that nanocapsules-CRJ hold promise as a potential therapeutic agent with both cytotoxic and immunomodulatory properties.

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“…(A) (B) Several approaches to enhancing the solubility and dissolution rate of ketoprofen have been documented, including the formation of an amorphous solid dispersion with some hydrophilic polymers [7][8][9], the formation of complex inclusions [10], simple eutectic mixtures [11], and nanosized particles [12,13]. However, in use, these methods can suffer from drawbacks, such as the low physical stability of the amorphous state, the high hygroscopicity of the solid dispersion system, and the physical instability of the colloidal dispersion in nanosized drug delivery [14,15].…”

Section: Introductionmentioning

confidence: 99%

Improved Solubility and Dissolution Rate of Ketoprofen by the Formation of Multicomponent Crystals with Tromethamine

Fitriani

Firdaus

Sidadang³

et al. 2022

Crystals

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This study aims to improve the dissolution rate of ketoprofen by preparing multicomponent crystals with tromethamine. The multicomponent crystals (equimolar ratio) of ketoprofen and tromethamine were prepared by the solvent co-evaporation method. The solid-state properties of the resulting powder were characterized by powder X-ray diffraction, DSC thermal analysis, FT–IR spectroscopy, solubility, and in vitro dissolution rate. The crystal structure of the multicomponent crystal was determined by single-crystal X-ray diffraction analysis. The results showed that the powder X-ray diffraction pattern of the ketoprofen–tromethamine binary system was different from that of the starting materials. This difference indicates the formation of a new crystalline phase between ketoprofen and tromethamine (equimolar ratio). The DSC thermogram of the ketoprofen–tromethamine binary system exhibited a single and sharp endothermic peak at 128.67 °C, attributed to the melting point of a multicomponent crystal of ketoprofen–tromethamine. A single-crystal X-ray analysis revealed that ketoprofen–tromethamine formed a layered structure, salt-type multicomponent crystal. The solubility and dissolution rate of the multicomponent crystal were notably enhanced compared to the intact ketoprofen. The ketoprofen–tromethamine binary system forms salt-type multicomponent crystals, which can significantly increase the solubility and dissolution rate.

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Ketoprofen-loaded rose hip oil nanocapsules attenuate chronic inflammatory response in a pre-clinical trial in mice

Cited by 13 publications

References 35 publications

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Polymeric Nanocapsules as Nanotechnological Alternative for Drug Delivery System: Current Status, Challenges and Opportunities

Immunomodulatory and Anticancer Effects of Fridericia chica Extract-Loaded Nanocapsules in Myeloid Leukemia

Improved Solubility and Dissolution Rate of Ketoprofen by the Formation of Multicomponent Crystals with Tromethamine

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