Key advances of carboxymethyl cellulose in tissue engineering &amp; 3D bioprinting applications

Zennifer, Allen; Senthilvelan, Praseetha; Sethuraman, Swaminathan; Sundaramurthi, Dhakshinamoorthy

doi:10.1016/j.carbpol.2020.117561

Cited by 150 publications

(70 citation statements)

References 118 publications

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“…Cellulose-based biomaterials express great potential in 3D bioprinting. CMC can be used as bioinks due to its excellent shear adjustment, alteration of viscosity, and attribute of shape [ 88 ]. For example, the application of direct ink writing as the printing technique for water-based ink of NaCMC with humidity control [ 89 ].…”

Section: Cellulose-based As Biomaterials Inkmentioning

confidence: 99%

Recent Advances in 3D Bioprinting: A Review of Cellulose-Based Biomaterials Ink

et al. 2022

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Cellulose-based biodegradable hydrogel proves to be excellently suitable for the medical and water treatment industry based on the expressed properties such as its flexible structure and broad compatibility. Moreover, their potential to provide excellent waste management from the unutilized plant has triggered further study on the advanced biomaterial applications. To extend the use of cellulose-based hydrogel, additive manufacturing is a suitable technique for hydrogel fabrication in complex designs. Cellulose-based biomaterial ink used in 3D bioprinting can be further used for tissue engineering, drug delivery, protein study, microalgae, bacteria, and cell immobilization. This review includes a discussion on the techniques available for additive manufacturing, bio-based material, and the formation of a cellulose-based hydrogel.

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Section: Cellulose-based As Biomaterials Inkmentioning

confidence: 99%

Recent Advances in 3D Bioprinting: A Review of Cellulose-Based Biomaterials Ink

et al. 2022

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“…Cellulose ethers can be found in an ample variety of solid and semisolid drug dosage forms owing to their thickening and interface stabilizing roles. Particularly, carboxymethyl cellulose (CMC) leads a large-scale market, compared to other cellulose derivatives, due to the simpler and more affordable synthesis routes and raw materials and also stimuli-responsive behavior (Alvarez-Lorenzo, Blanco-Fernandez, Puga, & Concheiro, 2013;Zennifer, Senthilvelan, Sethuraman, & Sundaramurthi, 2021).…”

Section: Introductionmentioning

confidence: 99%

“…Cellulose ethers, particularly CMC, have also recently been reported as useful structural components of bioinks for wound healing due to their matrix-forming capability, cell compatibility and cross-linking feasibility (Mallakpour, Tukhani, & Hussain, 2021). However, CMC-based inks are claimed to provide insufficient mechanical stability to the printed structures and, thus, incorporation of a variety of additives is assumed as mandatory (Zennifer et al, 2021). Nevertheless, this drawback could be related to the relatively low CMC concentrations tested so far.…”

Section: Introductionmentioning

confidence: 99%

3D printed carboxymethyl cellulose scaffolds for autologous growth factors delivery in wound healing

Díaz-Gómez

Gonzalez-Prada

Millán

et al. 2022

Carbohydrate Polymers

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This work aims to use carboxymethyl cellulose (CMC) as main structural and functional component of 3D printed scaffolds for healing of diabetic wounds. Differently from previous inks involving small contents in CMC, herein sterile (steam-heated) concentrated CMC solely dispersions (10-20%w/v) were screened regarding printability and fidelity properties. CMC (15%w/v)-citric acid inks showed excellent self-healing rheological properties and stability during storage. CMC scaffolds loaded with platelet rich plasma (PRP) sustained the release of relevant growth factors. CMC scaffolds both with and without PRP promoted angiogenesis in ovo, stem cell migration in vitro, and wound healing in a diabetic model in vivo. Transparent CMC scaffolds allowed direct monitoring of bilateral full-thickness wounds created in rat dorsum. CMC scaffolds facilitated re-epithelialization, granulation, and angiogenesis in full-thickness skin defects, and the performance was improved when combined with PRP. Overall, CMC is pointed out as outstanding component of active dressings for diabetic wounds.

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“…[ 7,8 ] CMC hydrogels can maintain a moist environment around the wound with their excellent water retention properties, which will facilitate the growth and re‐epithelialization of extracellular matrix. [ 9,10 ] Common preparations for cross‐linking CMC molecules to form hydrogels include the use of divalent ions or cross‐linking agents. [ 11–13 ] Ionic cross‐linked CMC hydrogels have poor flexibility, and their rapid chelation process is difficult to control.…”

Section: Introductionmentioning

confidence: 99%

One‐Pot Preparation of Polysaccharide‐Based Antibacterial Hydrogel for Skin Wound Repair

Geng

et al. 2022

Macro Materials & Eng

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Polysaccharide hydrogels are widely applied as wound dressings for skin wound repair due to their good biocompatibility and ability to regulate microenvironments. However, hydrogel application can result in skin wetting that can easily cause wound infections. Herein, a polysaccharide‐based antibacterial hydrogel that can promote skin wound repair is prepared by a one‐pot method. In this study, tannic acid (TA) is oxidized and cross‐linked with carboxymethyl chitosan (CMCS) through a Schiff base reaction to form the macromolecule CMCS‐TA. Carboxymethyl cellulose (CMC) cross‐links more easily with CMCS‐TA than CMCS when utilizing the cross‐linking agent carbondiimide hydrochloride (EDC). EDC has no cytotoxicity after hydrolysis and the hydrogel prepared by EDC cross‐linking has a low swelling rate. Due to the in situ reduction of Ag particles, the CMC/CMCS‐TA/Ag hydrogel exhibits good antibacterial properties against E. coli and S. aureus. Cytocompatibility tests and histological analysis indicate that the antibacterial hydrogel has good biocompatibility and can promote wound repair in a rat infection model. Therefore, the polysaccharide‐based hydrogel can be a promising wound dressing for skin wound repair.

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Key advances of carboxymethyl cellulose in tissue engineering & 3D bioprinting applications

Cited by 150 publications

References 118 publications

Recent Advances in 3D Bioprinting: A Review of Cellulose-Based Biomaterials Ink

Recent Advances in 3D Bioprinting: A Review of Cellulose-Based Biomaterials Ink

3D printed carboxymethyl cellulose scaffolds for autologous growth factors delivery in wound healing

One‐Pot Preparation of Polysaccharide‐Based Antibacterial Hydrogel for Skin Wound Repair

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