Key components of engineering vascularized 3-dimensional bioprinted bone constructs

Shahabipour, Fahimeh; Ashammakhi, Nureddin; Oskuee, Reza Kazemi; Bonakdar, Shahin; Hoffman, Tyler; Shokrgozar, Mohammad Ali; Khademhosseini, Ali

doi:10.1016/j.trsl.2019.08.010

Cited by 70 publications

(59 citation statements)

References 183 publications

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“…Dynamic culturing can provide continuous infiltrating flow of medium and/or compressive/tensile loading, which is most beneficial for cartilage and bone tissue engineering ( Butler et al, 2009 ). In case the technology reaches the stage of creating vasculature ( Shahabipour et al, 2020 ), research would be needed to determine if blood would be an adequate medium to facilitate nutrients and waste exchange.…”

Section: Post-printingmentioning

confidence: 99%

Safety Considerations in 3D Bioprinting Using Mesenchymal Stromal Cells

Belk

Tellisi

Macdonald

et al. 2020

Front. Bioeng. Biotechnol.

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Three-dimensional (3D) bioprinting has demonstrated great potential for the fabrication of biomimetic human tissues and complex graft materials. This technology utilizes bioinks composed of cellular elements placed within a biomaterial. Mesenchymal stromal cells (MSCs) are an attractive option for cell selection in 3D bioprinting. MSCs can be isolated from a variety of tissues, can pose vast proliferative capacity and can differentiate to multiple committed cell types. Despite their promising properties, the use of MSCs has been associated with several drawbacks. These concerns are related to the ex vivo manipulation throughout the process of 3D bioprinting. The herein manuscript aims to present the current evidence surrounding these events and propose ways to minimize the risks to the patients following widespread expansion of 3D bioprinting in the medical field.

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Section: Post-printingmentioning

confidence: 99%

Safety Considerations in 3D Bioprinting Using Mesenchymal Stromal Cells

Belk

Tellisi

Macdonald

et al. 2020

Front. Bioeng. Biotechnol.

Self Cite

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“…The gold standard for bone restoration still generally is autogenous bone grafts that are harvested from intra-or extra-oral sites; however, this has the limitation of low graft quantity, donor site morbidity, and infection. Although many researchers have made attempts to develop therapeutic approaches for the fabrication of human bone [121,123,124] as a highly ordered and vascularized tissue [125], few have succeeded in which there is still no effective treatment for most cases [126][127][128]. As a result, bone tissue engineering (BTE) undergoes a booming advancement as the alternative to bone grafting, where graft substitutes are made using biomaterials to replace or repair damaged bone defects [125].…”

Section: Skinmentioning

confidence: 99%

“…Although many researchers have made attempts to develop therapeutic approaches for the fabrication of human bone [121,123,124] as a highly ordered and vascularized tissue [125], few have succeeded in which there is still no effective treatment for most cases [126][127][128]. As a result, bone tissue engineering (BTE) undergoes a booming advancement as the alternative to bone grafting, where graft substitutes are made using biomaterials to replace or repair damaged bone defects [125]. Among different biomaterials, hydrogels are considered as promising materials for BTE due to their physical or structural similarity to natural tissues; however, hydrogels often suffer from poor mechanical properties specially in BTE applications [129].…”

Section: Skinmentioning

confidence: 99%

Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with focus on advanced fabrication techniques

et al. 2021

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“…[115] Finally, the high volume of bioprinted constructs will require addressing a well-known tissue engineering problem, the integration of a functional vasculature within the bioprinted constructs. [115,167] Despite a number of studies have addressed this challenge, [168][169][170] a reliable strategy is still lacking, especially for the manufacturing of microvascularized system. [167]…”

Section: Limitationsmentioning

confidence: 99%

Extrusion and Microfluidic‐Based Bioprinting to Fabricate Biomimetic Tissues and Organs

Davoodi

Sarikhani

Montazerian

et al. 2020

Adv Materials Technologies

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136

110

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Next generation engineered tissue constructs with complex and ordered architectures aim to better mimic the native tissue structures, largely due to advances in 3D bioprinting techniques. Extrusion bioprinting has drawn tremendous attention due to its widespread availability, cost‐effectiveness, simplicity, and its facile and rapid processing. However, poor printing resolution and low speed have limited its fidelity and clinical implementation. To circumvent the downsides associated with extrusion printing, microfluidic technologies are increasingly being implemented in 3D bioprinting for engineering living constructs. These technologies enable biofabrication of heterogeneous biomimetic structures made of different types of cells, biomaterials, and biomolecules. Microfluiding bioprinting technology enables highly controlled fabrication of 3D constructs in high resolutions and it has been shown to be useful for building tubular structures and vascularized constructs, which may promote the survival and integration of implanted engineered tissues. Although this field is currently in its early development and the number of bioprinted implants is limited, it is envisioned that it will have a major impact on the production of customized clinical‐grade tissue constructs. Further studies are, however, needed to fully demonstrate the effectiveness of the technology in the lab and its translation to the clinic.

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Key components of engineering vascularized 3-dimensional bioprinted bone constructs

Cited by 70 publications

References 183 publications

Safety Considerations in 3D Bioprinting Using Mesenchymal Stromal Cells

Safety Considerations in 3D Bioprinting Using Mesenchymal Stromal Cells

Recent progress in extrusion 3D bioprinting of hydrogel biomaterials for tissue regeneration: a comprehensive review with focus on advanced fabrication techniques

Extrusion and Microfluidic‐Based Bioprinting to Fabricate Biomimetic Tissues and Organs

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