The authors present an analysis of the correlation between demographic and territorial indicators and greenhouse gas (GHG) emissions, emphasizing the spatial aspect using statistical methods. Particular attention is given to the application of correlation techniques, considering the spatial correlation between the involved variables, such as demographic, territorial, and environmental indicators. The demographic data include factors such as population, demographic distribution, and population density; territorial indicators include land use, particularly settlements, and road soil occupancy. The aims of this study are as follows: (1) to identify the direct relationships between these variables and emissions; (2) to evaluate the spatial dependence between geographical entities; and (3) to contribute to generating a deeper understanding of the phenomena under examination. Using spatial autocorrelation analysis, our study aims to provide a comprehensive framework of the territorial dynamics that influence the quantity of emissions. This approach can contribute to formulating more targeted environmental policies, considering the spatial nuances that characterize the relationships between demographics, territory, and GHGs. The outcome of this research is the identification of a direct formula to obtain greenhouse gas emissions from data about land use starting from the case study of Pavia Province in Italy. In the paper, the authors highlight different methodologies to compare land use and GHG emissions to select the most feasible correlation formula. The proposed procedure has been tested and can be used to promote awareness of the spatial dimension in the analysis of complex interactions between anthropogenic factors and environmental impacts.