Considering the importance of addressing innovation issues that impact the development of economic sectors, this document presents the research work aimed at establishing a state of the art related to technology transfer and intermediation issues, which can be adopted in the innovation systems. In this case, the agro-industrial innovation system is taken as a reference from the perspective of a country, Colombia. Likewise, it is proposed to consider the synergy between actors such as the university and the industry, from a holistic vision of the systems. In this sense, and making use of the Scopus, Web of Science and Google Scholar databases, through the implementation of a methodology in which three main phases of search, selection and reading of scientific publications were generated, a set of documents was obtained, and through these it was possible to identify: concepts on innovation systems, aspects that intervene in transfer processes of technology especially related to the articulation of the actors that are part of the innovation systems, as well as the way in which these issues can be adopted, taking the agro-industrial sector as a reference. Thus, through this research, the existence of structural gaps in the networks of actors is highlighted as a key factor, which, when trying to be moderated through the intervention of government actors, also require the participation of intermediary innovation agents, that facilitate the articulation and flow of data, information and communication between those who develop technology and those who require these developments to mitigate a need in the productive sectors.