Key Features in the Management of Pulmonary Carcinosarcoma

Patrini, Davide; Adams, Benjamin; Pararajasingham, Jonathan; Shukla, Rajeev; Borg, Elaine; Hayward, Martin; Lawrence, David

doi:10.1155/2016/2020146

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…Primary lung carcinosarcoma is a rare tumour, representing roughly 0.1–1.0% of all lung cancers [ 7 – 9 ]. These tumours show a roughly 7 : 1 male-to-female ratio, present at a median age of 65 years, and are frequently associated with a history of heavy smoking.…”

Section: Discussionmentioning

confidence: 99%

Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma

Gleason

Haas

2017

Case Reports in Radiology

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A 76-year-old female with coronary artery disease, chronic obstructive pulmonary disease, diabetes mellitus type II, and 40 pack-year smoking history presented with a four-day history of cough, productive of green-yellow sputum. Chest X-ray revealed opacification of the left upper lung field, and computed tomography (CT) of the chest showed a large cavitary lesion invading the T2-T3 vertebral bodies, extending into the epidural space, giving rise to mild cord compression. Biopsy of the lesion revealed a poorly differentiated neoplasm composed of distinct epithelial and mesenchymal components, consistent with carcinosarcoma. A metastatic workup was negative. Primary lung carcinosarcoma is a rare tumour that can demonstrate an especially aggressive clinical course; diagnosis is often nuanced by limited sampling at initial presentation, especially in a setting of advanced disease and debility that precludes consideration for upfront resection or more extensive, invasive sampling.

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Section: Discussionmentioning

confidence: 99%

Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma

Gleason

Haas

2017

Case Reports in Radiology

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“…Thus, the authors proposed new therapeutic strategies based on better knowledge of the carcinogenesis of sarcomatoid carcinomas. Radiotherapy is also a well-established choice of treatment, which can reduce the local recurrence rate in cases with residual tumor [10]. Our patient is free of disease during this six-month follow-up without any adjuvant treatment.…”

Section: Discussionmentioning

confidence: 67%

A rare lung tumor: pulmonary carcinosarcoma

Kara¹,

Özkan²,

Çimenoğlu³

et al. 2019

Curr Thorac Surg

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Pulmonary sarcomatoid carcinoma is an extremely rare malignant lung tumor with an unfavorable prognosis, which shows carcinomatous and sarcomatous components. We present a case of 78-year-old patient with a middle lobe tumor who underwent a bronchial sleeve middle lobectomy. The tumor was a carcinosarcoma with squamous cell carcinoma and rhabdomyosarcoma components histologically. We tried to emphasize this extreme lung tumor and its clinicopathological features.

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“…It features easy relapse after surgical resection and resistance to radiotherapy and chemotherapy 46. The Mayo Clinic conducted a study and showed that the 5-year preoperative and postoperative survival for pulmonary CS patients was 21.3% and 28.7%, respectively, with an average postoperative survival of 9 months 47. The genomic alterations of pulmonary CS have been identified by using next-generation sequencing analysis 48.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology, site-specific characteristics and survival of carcinosarcoma: a retrospective study based on SEER database

Tang,

Zhou,

Wang

et al. 2023

BMJ Open

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ObjectivesCarcinosarcoma (CS) is a rare and biphasic malignancy characterised by a highly invasive biological nature and poor prognosis. This study explored the epidemiology, site-specific characteristics and survival outcome of CS.DesignWe conducted a retrospective study in the Surveillance, Epidemiology and End Results (SEER) database (1975–2018) for primary CS.Setting and participantsSEER database includes publicly available information from regional and state cancer registries in the US centres. A total of 5042 CS patients were identified. We selected the top five anatomic CS (uterus, double adnexa, lung, bladder and breast) patients for further analysis.Primary outcome measuresIncidence was estimated by geographical region, age, sex, race, stage and primary site. Trends were calculated using joinpoint regression. The cancer-specific survival (CSS) rate and initial treatment were summarised.ResultsNearly 80% of CS occurred in the uterus and double adnexa, followed by lung, bladder and breast. The elderly and black population presented the highest age-adjusted rate of CS. The rates of distant metastasis in CS progressively increased from 1989 to 2018. Atlanta was the area with the highest incidence at 0.7 per 100 000. Pulmonary and bladder CS more frequently occurred in men and were diagnosed with regional stage. Distant metastasis was mostly found in ovary/fallopian tube CS. Radiotherapy was more commonly applied in uterine CS, while adnexa CS cases were more likely to receive chemotherapy. Multiple treatments were more used in breast CS. Pulmonary CS seemed to suffer worse CSS (median: 9.92 months), for which radiotherapy might not provide survival benefits (HR 0.60, 95% CI 0.42 to 0.86). Compared with the common histological types in each site, CS had the shortest survival.ConclusionsCS has unique clinical features in each primary site. Substantial prognosis variances exist based on tumour locations. The aggressive course is the common feature in CS at all sites.

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Key Features in the Management of Pulmonary Carcinosarcoma

Cited by 7 publications

References 8 publications

Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma

Imaging, Histopathologic, and Treatment Nuances of Pulmonary Carcinosarcoma

A rare lung tumor: pulmonary carcinosarcoma

Epidemiology, site-specific characteristics and survival of carcinosarcoma: a retrospective study based on SEER database

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