Key genes and potential drugs in age-related hearing loss: transcriptome analysis of cochlear hair cells in old mice

Abstract

Materials and Methods Selection of presbycusis-related datasetsWe selected the GEO datasets in studies of cochlear hair cells using the term "presbycusis". The criteria were that the mice were divided into at least two groups: an old group and a young group, where the old group was at least 12 months of age, and the young group was less than or equal to 9 months. Overall, five datasets were collected: GSE153882, GSE121856, GSE98070, GSE45026, and GSE98071. The former three datasets provide the expression profiles of mRNAs, and the last two datasets provide that of miRNAs. Differentially expressed genesAll the datasets were analyzed with the DESeq2 R package to acquire the differentially expressed genes (DEGs). The fold change (FC) and P-value were obtained for each