Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells

Chen, Jingqiu; Zheng, Xiaodan; Rao, Nanquan; Huang, Yao; Liu, Juan; Li, Yanhong; Zhang, Jun

doi:10.1155/2021/5521715

Cited by 6 publications

(2 citation statements)

References 249 publications

(238 reference statements)

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“…It is now understood that DSCs can be readily obtained from tissues originating from the oral region [4]. To date, numerous different types of human DSCs have been identified and named according to their origin, including dental pulp stem cells (DPSCs) [5], stem cells from human exfoliated deciduous teeth (SHED) [6], stem cells from apical papilla (SCAPs) [7], periodontal ligament stem cells (PDLSCs) [8], dental follicle cells (DFCs) [9], and gingival mesenchymal stem cells (GMSCs) [10].…”

Section: Introductionmentioning

confidence: 99%

An overview of autophagy in the differentiation of dental stem cells

ZHAO,

JU,

et al. 2024

BIOCELL

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Dental stem cells (DSCs) have attracted significant interest as autologous stem cells since they are easily accessible and give a minimal immune response. These properties and their ability to both maintain self-renewal and undergo multi-lineage differentiation establish them as key players in regenerative medicine. While many regulatory factors determine the differentiation trajectory of DSCs, prior research has predominantly been based on genetic, epigenetic, and molecular aspects. Recent evidence suggests that DSC differentiation can also be influenced by autophagy, a highly conserved cellular process responsible for maintaining cellular and tissue homeostasis under various stress conditions. This comprehensive review endeavors to elucidate the intricate regulatory mechanism and relationship between autophagy and DSC differentiation. To achieve this goal, we dissect the intricacies of autophagy and its mechanisms. Subsequently, we elucidate its pivotal roles in impacting DSC differentiation, including osteo/ odontogenic, neurogenic, and angiogenic trajectories. Furthermore, we reveal the regulatory factors that govern autophagy in DSC lineage commitment, including scaffold materials, pharmaceutical cues, and the extrinsic milieu.The implications of this review are far-reaching, underpinning the potential to wield autophagy as a regulatory tool to expedite DSC-directed differentiation and thereby promote the application of DSCs within the realm of regenerative medicine.

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Section: Introductionmentioning

confidence: 99%

An overview of autophagy in the differentiation of dental stem cells

ZHAO,

JU,

et al. 2024

BIOCELL

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“…Current identified DSCs are dental pulp stem cells (DPSCs) (1,2), stem cells from human exfoliated deciduous teeth (SHED) (3), periodontal ligament stem cells (PDLSCs) (4), dental follicle precursor cells (DFPCs) (5), stem cells from apical papilla (SCAP) (6), gingival-derived MSCs (GMSCs) (7), and alveolar bone marrow-derived MSCs (ABMSCs) (8,9). In vitro identification demonstrated that DSCs positively expressed MSC-related markers, including CD13, CD29, CD44, CD59, CD73, CD90, CD105, CD146, and STRO-1; while negatively expressed hematopoietic markers, such as CD14, CD31, CD34, and CD45 (10)(11)(12). The key pluripotency markers (Oct4, Sox2, and Nanog) that are involved in maintaining the undifferentiated state were also expressed in DSCs with different levels (13).…”

Section: Introductionmentioning

confidence: 99%

Deciphering the Epigenetic Code of Stem Cells Derived From Dental Tissues

Zhao

Sun

et al. 2022

Front. Dent. Med

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Stem cells derived from dental tissues (DSCs) exhibit multipotent regenerative potential in pioneering tissue engineering regimens. The multipotency of DSCs is critically regulated by an intricate range of factors, of which the epigenetic influence is considered vital. To gain a better understanding of how epigenetic alterations are involved in the DSC fate determination, the present review overviews the current knowledge relating to DSC epigenetic modifications, paying special attention to the landscape of epigenetic modifying agents as well as the related signaling pathways in DSC regulation. In addition, insights into the future opportunities of epigenetic targeted therapies mediated by DSCs are discussed to hold promise for the novel therapeutic interventions in future translational medicine.

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Epigenetic control of dental stem cells: progress and prospects in multidirectional differentiation

Li,

Guo,

Yao

et al. 2024

Epigenetics & Chromatin

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Dental stem cells, with their exceptional proliferative capacity and multidirectional differentiation potential, hold significant promise for dental and oral tissue regeneration. Epigenetic inheritance, which involves stable and heritable changes in gene expression and function without alterations to the DNA sequence, plays a critical role in numerous biological processes. Environmental factors are particularly influential in epigenetic inheritance, as variations in exposure can lead to changes in epigenetic modifications that subsequently impact gene expression. Epigenetic mechanisms are widely involved in processes such as bone homeostasis, embryogenesis, stem cell fate determination, and disease development. Recently, the epigenetic regulation of dental stem cells has attracted considerable research attention. This paper reviews studies focused on the epigenetic mechanisms governing the multidirectional differentiation of dental stem cells.

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Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells

Cited by 6 publications

References 249 publications

An overview of autophagy in the differentiation of dental stem cells

An overview of autophagy in the differentiation of dental stem cells

Deciphering the Epigenetic Code of Stem Cells Derived From Dental Tissues

Epigenetic control of dental stem cells: progress and prospects in multidirectional differentiation

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