Key neurochemical markers for the prevention of suicide

Slater, Stacey; Villalba, Maria Marti; Davis, James A.

doi:10.1016/j.trac.2009.06.002

Cited by 5 publications

(2 citation statements)

References 87 publications

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“…Twin, family, and adoption studies suggest an important role of genetic factors in suicidal behaviour, with genes playing a role in about 30-50 % of cases that involve suicidal behaviour (Bondy et al 2006 ;Mann et al 1999Mann et al , 2009McGuffin et al 2001 ;Roy et al 1995 ;Statham et al 1998). Candidate genes thought to be related to suicide are mostly those involved in serotonin and catecholamine pathways [serotonin transporter (SERT or 5-HTT), tryptophan hydroxylase (TPH), monoamine oxidase (MAOA), serotonin receptors (5-HT 1A , 5-HT 1B , and 5-HT 2A ), catechol-O-methyltransferase (COMT), tyrosine hydroxylase (TH) and DOPA decarboxylase] (Mann et al 2009 ;Slater et al 2009). The association between catecholaminergic dysfunction and suicide behaviour is based on the findings of a higher concentration of norepinephrine and decreased a 2 -adrenergic binding in the prefrontal cortex of suicide victims (Arango et al 1993) or lower levels of 3-methoxy-4-hydroxyphenylglycol (a metabolite of norepinephrine) and homovanillic acid (a metabolite of dopamine) in the cerebrospinal fluid of subjects who attempted suicide (Engstrom et al 1999 ;Jones et al 1990 ;Roy et al 1986) than in control subjects.…”

Section: Introductionmentioning

confidence: 99%

Association study of a functional catechol- O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence

Nedić

Nikolac

Sviglin

et al. 2010

Int. J. Neuropsychopharm.

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Alcohol dependence is frequently associated with aggressive and suicidal behaviour. Genetic factors contribute to both behaviours. Candidate genes, related to suicide and aggression, include genes involved in serotonin, norepinephrine and dopamine pathways. The enzyme catechol-O-methyl transferase (COMT) degrades dopamine, epinephrine and norepinephrine. The functional polymorphism (COMT Val108/158Met) affects COMT activity, with the valine (Val) variant associated with higher and the methionine (Met) variant with lower COMT activity. This polymorphism is associated with aggressive and suicidal behaviour, but the literature data on this relationship is contradictory and inconsistent. The hypothesis of this study was that Met allele carriers with alcohol dependence will have a higher frequency of suicide attempts compared to other genotypes. Participants were 312 male and 81 female medication-free patients with alcohol dependence and 487 male and 122 female unrelated, non-suicidal medication-free Caucasian healthy subjects. Our results showed significant (χ2 test with standardized residuals) differences in the frequencies of COMT variants in all alcoholics, alcoholics with different comorbid diagnoses, and in male but not in female alcoholics, with or without suicide attempts. Male alcoholic suicide attempters, compared to male non-attempters, had the higher frequency of Met/Met genotype or Met allele, and significantly (Kruskal-Wallis ANOVA on ranks and Mann-Whitney test) higher aggression and depression scores. These results confirmed the associations between Met allele and aggressive behaviour or violent suicide attempts in various psychiatric diagnoses, and suggested that Met allele of the COMT Val108/158 Met might be used as an independent biomarker of suicidal behaviour across different psychopathologies.

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Section: Introductionmentioning

confidence: 99%

Association study of a functional catechol- O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence

Nedić

Nikolac

Sviglin

et al. 2010

Int. J. Neuropsychopharm.

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“…They are metabolized by a series of enzymes to produce various acidic metabolites, including 3,4-dihydroxyphenyl acetic acid (DOPAC), 3,4-dihydroxymandelic acid (DOMA), homovanillic acid (HVA), vanilmandelic acid (VMA) and iso-VMA (de Jong et al, 2011;Kågedal and Goldstein, 1988;Mathieu et al, 1980;Tsunoda, 2006;Verheyden and Ebinger, 1975). 5-Hydroxyindole acetic acid (5-HIAA) is an acidic metabolite of serotonin (de Jong et al, 2011;Kema et al, 2000;Slater et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Acidic metabolite profiling analysis of catecholamine and serotonin as O‐ethoxycarbonyl/tert‐butyldimethylsilyl derivatives by gas chromatography–mass spectrometry

Nguyen

Cho

Kim

et al. 2012

Biomedical Chromatography

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A novel derivatization method was developed for the simultaneous determination of six acidic metabolites of catecholamine and serotonin by gas chromatography–mass spectrometry (GC‐MS). The metabolites were converted to O‐ethoxycarbonyl/tert‐butyldimethylsilyl (EOC/TBDMS) derivatives for the direct GC‐MS analysis in selected ion monitoring mode. Their mass spectral pattern as EOC/TBDMS derivatives showed characteristic fragment ions of [M – 15]+ and [M – 57]+, which permitted rapid and accurate structural confirmation of acidic metabolites. The present method was linear (r ≥ 0.998), reproducible (percentage relative standard deviation = 1.0–10.0) and accurate (% relative error = −9.7–9.8) with detection limits of 0.001–4.7 ng/mL. When applied to human urine samples, the method allowed simultaneous determination of six acidic metabolites of catecholamine and serotonin. Copyright © 2012 John Wiley & Sons, Ltd.

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Advances and challenges in neurochemical profiling of biological samples using mass spectrometry coupled with separation methods

Lee

Park

Lee

et al. 2018

TrAC Trends in Analytical Chemistry

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Key neurochemical markers for the prevention of suicide

Cited by 5 publications

References 87 publications

Association study of a functional catechol- O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence

Association study of a functional catechol- O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence

Acidic metabolite profiling analysis of catecholamine and serotonin as O‐ethoxycarbonyl/tert‐butyldimethylsilyl derivatives by gas chromatography–mass spectrometry

Advances and challenges in neurochemical profiling of biological samples using mass spectrometry coupled with separation methods

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