This paper reports a comparative study of the scientific publications of double first-class universities based on international and domestic Chinese databases from 2006 to 2018. The main results are as follows. Quantitatively, the absolute total number of articles published by Chinese universities has increased. Specifically, the number of international publications in the natural and social sciences from double first-class universities showed an increasing trend, but the number of domestic journal articles showed the reverse trend. Moreover, based on the number of papers published by each university over the years, we recognized that the ranking changes of universities fall into four categories: rising, declining, stable, and fluctuating. Qualitatively, the international and domestic publications issued by double first-class universities greatly improved from 2006 to 2018. Moreover, scientific publications, either international or domestic, were unevenly distributed among the double first-class universities. In general, the double first-class universities developed rapidly in recent years and play an important role in the development of science and technology in China.