Key role of 5-HT 3 receptors in the nucleus tractus solitarii in cardiovagal stress reactivity

Sévoz‐Couche, Caroline; Brouillard, Charly

doi:10.1016/j.neubiorev.2016.04.014

Cited by 10 publications

(4 citation statements)

References 169 publications

(172 reference statements)

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“…Vagally-mediated RSA can be modulated by superior central influences through their actions on vagal motor neurons. For example, direct and indirect influences of central structures involved in stress, like the dorsomedial nucleus of the hypothalamus (DiMicco et al, 2002;Sévoz-Couche et al, 2013, 2003Sévoz-Couche and Brouillard, 2017), decrease the baroreflex gain and reduce the tonic baroreceptor drive on vagal motor neurons. This results in the diminution of the basal level of vagal activity and therefore the decrease of RSA (Brouillard et al, 2020(Brouillard et al, , 2019Sévoz-Couche et al, 2013, 2003.…”

Section: Ii-central and Reflex Interactions Involved In Heart Rate Va...mentioning

confidence: 99%

Heart rate variability and slow-paced breathing:when coherence meets resonance

Sévoz‐Couche

Laborde

2022

Neuroscience & Biobehavioral Reviews

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Section: Ii-central and Reflex Interactions Involved In Heart Rate Va...mentioning

confidence: 99%

Heart rate variability and slow-paced breathing:when coherence meets resonance

Sévoz‐Couche

Laborde

2022

Neuroscience & Biobehavioral Reviews

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“…Correlation between serotonin and the ANS, both of which have similar regulatory functions, has been reported previously 15 – 19 . Structurally, serotonergic neurons originating from the raphe nucleus in the midbrain project onto the nucleus tractus solitarius, which is responsible for cardiovascular reflexes and ANS function 15 , 16 . Clinically, the tryptophan depletion test, which decreases the serotonin level, may lead to lower HRV and more severe depressive symptoms 17 .…”

Section: Introductionmentioning

confidence: 99%

Prefrontal cortex modulates the correlations between brain-derived neurotrophic factor level, serotonin, and the autonomic nervous system

Chang

Lee

Hung

et al. 2018

Sci Rep

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Top-down regulation in the human brain and anatomical connections between the prefrontal cortex (PFC) and specific catecholamine-related regions have been well-studied. However, the way in which the PFC modulates downstream neuro-networks in terms of serotonin and the autonomic nervous system (ANS) by variation in the level of brain-derived neurotrophic factor (BDNF) is still unclear. We recruited sixty-seven healthy subjects. Serotonin transporter (SERT) availability was examined by SPECT with [123I]ADAM analysis; heart rate variability (HRV) testing was performed, and the BDNF level was measured. The Wisconsin card-sorting test (WCST), which assesses PFC activation, was also conducted. The interactions of BDNF level and SERT availability were significant in relation to the HRV indexes of low frequency, high frequency, total power, and mean heart rate range. Moderate to significant positive correlations between SERT availability and the above-mentioned HRV indexes existed only in subjects with a low BDNF level. Furthermore, in the low BDNF level group, only those with high WCST perseveration errors or low category completions exhibited significant positive correlations between SERT availability and HRV indexes. A lower BDNF level and poorer PFC function might modulate the synergistic effects of serotonergic and ANS systems in order to maintain brain physiological and psychological homeostasis.

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“…Glutamatergic transmission in the NTS is modulated by a complex variety of other transmitters (see Sevoz-Couche & Brouillard, 2017), with 5-hydroxytryptamine (serotonin, 5-HT) considered to play a key role in this important cardiovascular sensory nucleus (Ramage and Villalón, 2008; Hosford and Ramage, 2019). The transmitters and receptors involved in neuron-neuron communication necessary for reflex integration have been well studied.…”

Section: Introductionmentioning

confidence: 99%

Astrocytes modulate baroreceptor reflex sensitivity at the level of the nucleus of the solitary tract

Mastitskaya

Turovsky

Marina

et al. 2019

Preprint

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Astrocytes play an important role in cardiovascular reflex integration at the level of the nucleus tractus solitarii (NTS). Existing reports from brainstem slice preparations suggest that astrocytes here respond to input from the solitary tract by increasing intracellular calcium. However, the physiological significance of this neuron-astrocyte signaling in vivo remains unknown. Here, we report that stimulation of the vagus nerve in an anesthetized rat induced rapid [Ca2+]i increases in astrocytes transduced to express calcium sensor GCaMP6. The receptors involved were determined using brainstem-derived astroglial cell cultures were loaded with [Ca2+] indicator Fura-2. 5-HT (10 µM) caused robust increases in [Ca2+]i, and pharmacological interrogation revealed the expression of functional 5-HT2A receptors. This observation was confirmed in vivo: intravenous administration of ketanserin decreased the magnitude of [Ca2+]i responses, induced by vagal afferent simulation, by ∼50%. However, the response was completely blocked by topical application of the AMPA receptor antagonist CNQX alone. To investigate the role of astrocyte-neuron communication, the vesicular release in the NTS astrocytes was blocked by virally driven expression of a dominant-negative SNARE protein in vivo. This increased baroreflex sensitivity in awake animals, which was also observed in anesthetized animals after topical application of the P2Y1 receptor antagonist MDS-2500 to the NTS. We hypothesize that NTS astrocytes respond to incoming afferent release of glutamate and this response is modulated by 5-HT originating from vagal afferents or other sources. ATP is then released, which acts on inhibitory interneurons via P2Y1 receptors and thus modulates the expression of cardiovascular reflexes.Significance statementCardiorespiratory nuclei in the brainstem integrate cardiovascular sensory information to optimise tissue perfusion and blood gas concentrations. We describe experimental evidence that NTS astrocytes participate in setting the baroreflex sensitivity by release of ATP acting on P2Y1 receptors on inhibitory interneurons. Activation of astrocytes is partly under control of 5-HT co-released with glutamate from vagal afferents, which allows modulation of autonomic response to high frequency/duration of afferent stimulation by monitoring extra-synaptic 5-HT acting on glial 5-HT2A receptors. This could represent a signaling pathway that is activated under pathological conditions and is responsible for baroreflex impairment in conditions that result in astrogliosis, for example from systemic inflammatory response or chronic hypoxia/hypercapnia.

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Key role of 5-HT 3 receptors in the nucleus tractus solitarii in cardiovagal stress reactivity

Cited by 10 publications

References 169 publications

Heart rate variability and slow-paced breathing:when coherence meets resonance

Heart rate variability and slow-paced breathing:when coherence meets resonance

Prefrontal cortex modulates the correlations between brain-derived neurotrophic factor level, serotonin, and the autonomic nervous system

Astrocytes modulate baroreceptor reflex sensitivity at the level of the nucleus of the solitary tract

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