2016
DOI: 10.1016/j.clinthera.2016.02.028
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Key Role of DAMP in Inflammation, Cancer, and Tissue Repair

Abstract: Due to the bivalent nature of DAMP, it is often difficult to explain the relative role of DAMP in inflammation versus its role in tissue repair. However, this point is crucial as DAMP-related treatments move into clinical practice.

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Cited by 146 publications
(90 citation statements)
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“…In addition to their proinflammatory roles, recent studies have linked DAMPs to noninflammatory functions such as promoting cellular migration and proliferation, angiogenesis, and tissue repair (33,40). In particular, HMGB1 was shown to contribute to spinal cord regeneration in animal models where spontaneous regeneration occurs (41,42).…”
Section: Discussionmentioning
confidence: 99%
“…In addition to their proinflammatory roles, recent studies have linked DAMPs to noninflammatory functions such as promoting cellular migration and proliferation, angiogenesis, and tissue repair (33,40). In particular, HMGB1 was shown to contribute to spinal cord regeneration in animal models where spontaneous regeneration occurs (41,42).…”
Section: Discussionmentioning
confidence: 99%
“…More importantly, our siRNA knockdown studies resulted in significant effects on HMGB1 related vasculogenic/angiogenic functions. High-mobility group box-1 (HMGB1) protein is a transcription factor that has a dual role as a mobile chromatin protein and as a cytokine49. Amongst its functions, HMGB1 has been implicated in tissue repair and regeneration by promoting chemotaxis of stem/progenitor cells, stimulating the proliferation of tissue resident stem/progenitor cells including endothelial cells and vascular smooth muscle cells, acting as a proangiogenic cytokine and promoting secretion of proangiogenic cytokines such as VEGF and CXCL85051525354.…”
Section: Discussionmentioning
confidence: 99%
“…To further find conclusive evidence regarding the regulation of HMGB1 in pro-inflammatory function after chemotherapy, ATRA-induced NB4 cells that were incubated with 10 μg/ml neutralizing antibody against HMGB1 [20] showed partial reduction of TNF-α and IL-1β secretion compared to the negative control (Figure 7A). In addition, treatment of HMGB1-neutralizing antibody partially inhibited ICAM-1 elevation (Figure 7B) and reduced ERK1/2 phosphorylation compared to the ATRA-treated group (Figure 7C).…”
Section: Resultsmentioning
confidence: 99%
“…Emigration of ATRA-treated APL cells into lungs and other tissues recapitulates the molecular events during inflammation and immune responses [21]. The major molecular mediators of inflammation during ATRA-induced APL are pro-inflammatory cytokines and ICAM-1 [20, 22]. ATRA induces release of early pro-inflammatory cytokines such as TNF-α and IL-1β [22, 23], which promote endothelial adhesion in NB4 cells [24, 25].…”
Section: Discussionmentioning
confidence: 99%