Key roles of hepatologists in successful liver transplantation

Kogiso, Tomomi; Tokushige, Katsutoshi

doi:10.1111/hepr.13183

Cited by 4 publications

(2 citation statements)

References 92 publications

(180 reference statements)

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“…Liver transplantation is an effective treatment for patients with ALF in whom the prognosis appears poor 12 ; however, the waiting time to liver transplantation is considerable as several preparatory steps are required 20 . The present study revealed that registration on the referral system increased the time to onset of HE; therefore benefiting patients who require liver transplantation by allowing them to prepare for intensive care before the development of HE.…”

Section: Discussionmentioning

confidence: 99%

Early identification using the referral system prolonged the time to onset for hepatic encephalopathy after diagnosing severe acute liver injury

Kakisaka

Suzuki

Abe

et al. 2020

Sci Rep

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In 2004, we implemented a referral system for patients with acute liver injury (ALI) based on an established formula that estimates the risk of progression to acute live failure (ALF); however, the benefits of the system for patients with severe acute liver injury (SLI) remain unclear. We have evaluated the clinical significance of the referral system for SLI patients. Patients with ALI/SLI who were consecutively and prospectively listed on the system between 2004 and 2018 were analyzed. Of the 371 ALI/SLI/ALF patients on the system, 124 satisfied the criteria for SLI; 34 of these 124 progressed to SLI after registration. Multivariate analysis using age, sex, AST, ALT, creatinine, total bilirubin, prothrombin, presence of hepatic encephalopathy (HE), and SLI at registration revealed that HE was associated with high mortality. Among the 23 patients who developed HE, five who progressed to SLI after registration showed an increased time to HE development compared with patients who had SLI at the time of registration. However, there was no significant difference in survival time after HE development. We concluded that early identification of SLI patients using the referral system increased the time from SLI diagnosis to HE development.

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Section: Discussionmentioning

confidence: 99%

Early identification using the referral system prolonged the time to onset for hepatic encephalopathy after diagnosing severe acute liver injury

Kakisaka

Suzuki

Abe

et al. 2020

Sci Rep

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“…In Japan, although the use of HBIG is associated with several issues, such as a high cost and the emergence of escape mutant, HBIG monotherapy is the dominant form of prophylaxis for HBV recurrence after LT from anti-HBc-positive donors (4,16,23,24). However, recent clinical practice guidelines of AASLD and EASL recommend the administration of antiviral therapy, such as LAM, ETV, tenofovir disoproxil fumarate (TDF), or tenofovir alafenamide (TAF), as these antiviral drugs function as cost-effective treatments due to the low rates of HBV recurrence (< 3%) (5,6,25).…”

Section: Discussionmentioning

confidence: 99%

Hepatitis B virus recurrence after living donor liver transplantation of anti-HBc-positive grafts: A 22-year experience at a single center

Bae

Akamatsu

Togashi

et al. 2019

BST

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The use of hepatitis B core antibody (anti-HBc)-positive grafts is one strategy for expanding the donor pool for liver transplantation (LT). The aim of this study was to determine the risk factors associated with hepatitis B virus (HBV) recurrence after living donor LT (LDLT) of anti-HBc-positive grafts. From January 1996 to December 2018, a total of 609 LDLT procedures were performed at our center. A retrospective review was performed for 31 patients (23 males and 8 females; median age = 47 years) who underwent LDLT for HBVunrelated liver disease from anti-HBc-positive donors. The factors associated with HBV recurrence were evaluated and compared between the HBV recurrence and non-recurrence groups. The median follow-up period after LT was 135 months (range, 6-273 months). Four of 31 patients (12.9%) developed post-LT HBV recurrence. All four cases were HBV-naïve patients (anti-HBc-negative and Hepatitis B surface antibody-negative). The median interval between LDLT and HBV recurrence was 42 months (range, 20-51). The overall actuarial rates of HBV recurrence at 1, 3, 5, 10, and 20 years were 0%, 7.2%, 15.7%, 15.7%, and 15.7%, respectively. Although there were no significant differences between the HBV recurrence and non-recurrence groups, HBV recurrence tended to occur in HBV-naïve recipients (P = 0.093). HBV-naïve status may contribute to HBV recurrence after LDLT for HBV-unrelated liver disease from anti-HBc-positive donors. Careful monitoring for serological HBV markers is needed, particularly in this group.

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Prognostic Implications of Physical Frailty and Sarcopenia Pre and Post Transplantation

Buettner

IJzermans

Vugt

2019

Frailty and Sarcopenia in Cirrhosis

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Key roles of hepatologists in successful liver transplantation

Cited by 4 publications

References 92 publications

Early identification using the referral system prolonged the time to onset for hepatic encephalopathy after diagnosing severe acute liver injury

Early identification using the referral system prolonged the time to onset for hepatic encephalopathy after diagnosing severe acute liver injury

Hepatitis B virus recurrence after living donor liver transplantation of anti-HBc-positive grafts: A 22-year experience at a single center

Prognostic Implications of Physical Frailty and Sarcopenia Pre and Post Transplantation

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