Key-study on plasma-induced degradation of cephalosporins in water: Process optimization, assessment of degradation mechanisms and residual toxicity

Meropoulis, S.; Giannoulia, S.; Skandalis, Spyros S.; Rassias, Gerasimos A.; Aggelopoulos, C.A.

doi:10.1016/j.seppur.2022.121639

Cited by 26 publications

(6 citation statements)

References 72 publications

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“…[12] The authors attributed an essential role to peroxynitrite generated by the reaction between H 2 O 2 and nitrite produced in plasma, validating this statement through the slow AMX removal observed in chemical tests with solutions containing H 2 O 2 and NO 2 − . A similar hypothesis has been stated by Meropoulis et al [58] for other beta-lactam antibiotics, based on similar removal efficiency obtained in their experiments for air and oxygen plasma. Although in the present work ROS appears to play a lead role in the degradation, RNS involvement cannot be excluded.…”

Section: Degradation Of Antibiotics In Mixturesupporting

confidence: 89%

Removal of a mixture of antibiotics in water using nonthermal plasma

Bilea

Tian

Măgureanu

et al. 2023

Plasma Processes & Polymers

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A dielectric barrier discharge with falling liquid film was used to degrade the antibiotics amoxicillin and sulfamethoxazole in water. The antibiotic concentrations decrease exponentially during plasma treatment and have similar half‐life time, in the range 4–9 min. By increasing the discharge power (9.1–20.2 W), faster removal of the contaminants is obtained, but the energy efficiency remains almost the same, 3–4 g/kWh at 50%. Oxygen considerably improves the energy yield by a factor of two as compared with air, due to more effective formation of reactive oxygen species. It was found that the degradation of antibiotics in mixture essentially depends on the overall initial concentration, this behavior being attributed to the similar reactivity of the two investigated compounds.

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Section: Degradation Of Antibiotics In Mixturesupporting

confidence: 89%

Removal of a mixture of antibiotics in water using nonthermal plasma

Bilea

Tian

Măgureanu

et al. 2023

Plasma Processes & Polymers

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“…•O emissions at 777 and 844 nm [15], and weak O 2 + emissions [29]. Under argon-plasma, the spectrum is dominated by multiple argon transition lines (696 to 852 nm), •OH, and weak •O emissions [30].…”

Section: Electrical and Optical Plasma Characterizationmentioning

confidence: 99%

“…[13,14]. Normally, after plasma treatment, the antibiotics are decomposed into less toxic and harmful intermediates, if complete mineralization cannot be achieved [15]. However, the effectiveness of most plasma reactors (e.g., gas-liquid DBD) is limited by the short lifetime of the species and their low penetration into the liquid phase [16].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Synergistic Mechanisms of Nanopulsed Plasma Bubbles and Photocatalysts for Trimethoprim Degradation and Mineralization in Water

Tsokanas,

Aggelopoulos

2024

Nanomaterials

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In this study, the synergetic action of nanopulsed plasma bubbles (PBs) and photocatalysts for the degradation/mineralization of trimethoprim (TMP) in water was investigated. The effects of ZnO or TiO2 loading, plasma gas, and initial TMP concentration were evaluated. The physicochemical characterization of plasma-treated water, the quantification of plasma species, and the use of appropriate plasma species scavengers shed light on the plasma-catalytic mechanism. ZnO proved to be a superior catalyst compared to TiO2 when combined with plasma bubbles, mainly due to the increased production of ⋅OH and oxygen species resulting from the decomposition of O3. The air–PBs + ZnO system resulted in higher TMP degradation (i.e., 95% after 5 min of treatment) compared to the air–PBs + TiO2 system (i.e., 87%) and the PBs-alone process (83%). The plasma gas strongly influenced the process, with O2 resulting in the best performance and Ar being insufficient to drive the process. The synergy between air–PBs and ZnO was more profound (SF = 1.7), while ZnO also promoted the already high O2–plasma bubbles’ performance, resulting in a high TOC removal rate (i.e., 71%). The electrical energy per order in the PBs + ZnO system was very low, ranging from 0.23 to 0.46 kWh/m3, depending on the plasma gas and initial TMP concentration. The study provides valuable insights into the rapid and cost-effective degradation of emerging contaminants like TMP and the plasma-catalytic mechanism of antibiotics.

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“…Cephalosporin is a commonly used antibiotic for the treatment and prevention of bacterial diseases, for example, genital tract infections in humans, respiratory tract infections and intramammary infections in animals [19]. The concentration of cephalosporins detected in different water samples varies from ng/L to mg/L [20]. Cefotaxime sodium (CTX), which belongs to the third-generation cephalosporin, is the third most-detected cephalosporin in water environments [19].…”

Section: Introductionmentioning

confidence: 99%

Cefotaxime Exposure-Caused Oxidative Stress, Intestinal Damage and Gut Microbial Disruption in Artemia sinica

Pang,

Zheng,

Wang

et al. 2024

Microorganisms

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Cefotaxime (CTX) is an easily detectable antibiotic pollutant in the water environment, but little is known about its toxic effects on aquatic invertebrates, especially on the intestine. Here, we determined the oxidative stress conditions of A. sinica under CTX exposure with five concentrations (0, 0.001, 0.01, 0.1 and 1 mg/L) for 14 days. After that, we focused on changes in intestinal tissue morphology and gut microbiota in A. sinica caused by CTX exposure at 0.01 mg/L. We found malondialdehyde (MDA) was elevated in CTX treatment groups, suggesting the obvious antibiotic-induced oxidative stress. We also found CTX exposure at 0.01 mg/L decreased the villus height and muscularis thickness in gut tissue. The 16S rRNA gene analysis indicated that CTX exposure reshaped the gut microbiota diversity and community composition. Proteobacteria, Actinobacteriota and Bacteroidota were the most widely represented phyla in A. sinica gut. The exposure to CTX led to the absence of Verrucomicrobia in dominant phyla and an increase in Bacteroidota abundance. At the genus level, eleven genera with an abundance greater than 0.1% exhibited statistically significant differences among groups. Furthermore, changes in gut microbiota composition were accompanied by modifications in gut microbiota functions, with an up-regulation in amino acid and drug metabolism functions and a down-regulation in xenobiotic biodegradation and lipid metabolism-related functions under CTX exposure. Overall, our study enhances our understanding of the intestinal damage and microbiota disorder caused by the cefotaxime pollutant in aquatic invertebrates, which would provide guidance for healthy aquaculture.

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Key-study on plasma-induced degradation of cephalosporins in water: Process optimization, assessment of degradation mechanisms and residual toxicity

Cited by 26 publications

References 72 publications

Removal of a mixture of antibiotics in water using nonthermal plasma

Removal of a mixture of antibiotics in water using nonthermal plasma

Exploring the Synergistic Mechanisms of Nanopulsed Plasma Bubbles and Photocatalysts for Trimethoprim Degradation and Mineralization in Water

Cefotaxime Exposure-Caused Oxidative Stress, Intestinal Damage and Gut Microbial Disruption in Artemia sinica

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