Background: Teenage pregnancy remains an important and complex issue around the world, with reports indicating that Africa has higher rates than other continents. Studies have indicated that social and economic determinants are associated with these higher rates. Therefore this study aims to identify the social and economic influencers of teenage pregnancy which would help develop a best-practice approach to reduce its incidence in Africa. Methods: Data sets from the World Bank Organisation between 2008 and 2010 specific to 51 Africa countries were obtained to conduct this study, based on availability. Independent t-test, Spearman's correlation and regression analysis were performed. The eight social and economic variables used in this study are: GDP per capita, GINI index, Female Literacy rate, Health expenditure, Unemployed female rate, Gender equality, Contraceptive prevalence and urban population rate. Results: Independent t-test revealed that in countries where teenage pregnancy rate is high, Literacy rate, contraceptive prevalence rate and Healthcare expenditure rate was low. Spearman correlation indicated that female literacy rate, Healthcare expenditure, GDP per capita and Contraceptive prevalence had a significant inverse relationship with teenage pregnancy rate. Logistic regression indicates that Female Literacy rate is the best predictor of teenage pregnancy in Africa.