2022
DOI: 10.1101/2022.03.05.483140
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Key transcription factors influence the epigenetic landscape to regulate retinal cell differentiation

Abstract: During development, all retinal cell types emerge from multipotent retinal progenitor cells (RPCs) following distinct trajectories. Each lineage is subject to regulation by multiple intrinsic and extrinsic factors, which converge onto the epigenetic landscape to dictate the collective gene expression profile and thereby the phenotypes of individual cell states/types. Recent scRNA-seq studies have further delineated these trajectories, providing a general picture of the relationships between the different cell … Show more

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