“…Of the 6 issues of 2016, 2 are special issues, guest-edited by Pio Zeppa and Adhemar Longatto-Filho, who deserve our special thanks for their major effort and outstanding input to complete these assignments. Finally, the number of single case reports (Novel Insights from Clinical Practice) submitted has declined steadily in 2016, in accordance with the new publication policy announced in 2013 [2]. …”