“…Here, the combination of diagnostics and therapeutics, in the form of nanomaterial-derived theranostics, seems to be a promising avenue to precisely target malignancies at the cellular level and deliver tailored treatments to the appropriate recipient, thus, reducing patients’ burden caused by high-dosage application of pharmaceutical remedies. All these approaches, however, hinge on a full understanding of all aspects of cancer biology, such as the biology of oncogenes and tumor-suppressors and the role of the tumor environment in the genesis and the progression of cancers, as well as the influence of hypoxia exerted on the properties of cancers (see [ 62 , 63 , 64 ] and references therein as guides to principles and recent advantages).…”