Khat Chewing and Lipid Profile in Human and Experimental Animals

Al-Duais, Mohammed A.; Al-Awthan, Yahya S.

doi:10.1155/2021/6001885

Cited by 4 publications

(3 citation statements)

References 54 publications

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“…There are no age-specific or gender-specific restrictions on khat consumption. 22 In many Western countries, chewing khat is illegal. Chewing khat has spread significantly to many countries in Asia, Europe, America, and Australia as a result of many waves of migration.…”

Section: Worldwide Spreadmentioning

confidence: 99%

Glycemic effects of <em>Catha edulis</em>

Odhaib

Al-Sharafi²,

Mansour³

2022

J Biol Res

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More than 20 million people in the East African horn and the southern Arabian Peninsula chew khat (Catha edulis) on a daily basis. The glycemic effect of khat chewing, regardless of diabetes status, is still being debated. Using studies from countries where chewing khat is common, we attempted to discuss the potential glycemic effects of Catha edulis in humans and some animal models. This review included a thorough search in PubMed and the Cochrane Library using PRISMA guidelines, with words like (Khat) and (Qat) serving as query indicators for (diabetes) and (glucose), with no language or species restrictions. Khat is chewed for its stimulating and enjoyable properties. Despite a relatively small number of studies on khat’s glycemic effect, the debate continues. Many studies have linked the glycemic effect of khat leaves to their freshness and the duration of the stimulant effect. Although only in animal models, khat’s destructive effect on pancreatic -cells could cause some dysglycemic effects. The cathinone cannot be blamed for the glycemic effect.

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Section: Worldwide Spreadmentioning

confidence: 99%

Glycemic effects of <em>Catha edulis</em>

Odhaib

Al-Sharafi²,

Mansour³

2022

J Biol Res

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“…Dyslipidemia is a term referring to the disorders of lipoprotein metabolism and is clinically characterized by elevated plasma levels of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglycerides. Available data exploring khat effects on lipid profile are scarce, and conflicting [18].…”

Section: Dyslipidemiamentioning

confidence: 99%

Khat (Catha edulis) as a risk factor for cardiovascular disorders: Controversies and facts

Aleemallah¹

2022

YJM

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The leaves of khat (Catha edulis) are chewed as a social habit for the central stimulant action of their cathinone content. There is growing concern about the health hazards of chronic khat chewing. Many authors have addressed the adverse effects of khat chewing on the cardiovascular and other systems. Based on a limited number of case reports and few prospective controlled studies, associations between khat chewing and the occurrence of myocardial infarction, dilated cardiomyopathy, and vascular diseases such as hypertension and cerebrovascular ischemia have been proposed. This review outlines the current knowledge on the adverse health effects of khat chewing on the cardiovascular system, assesses the strength and the limitations of the studies, and identifies the questions that the future studies should address.

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“…Dyslipidemia refers to an elevated amount of serum TC, LDL‐C, and TG and a lower HDL‐C because of problems with lipoprotein metabolism. Dyslipidemia increases CVD and atherosclerosis‐related risk (Al‐Duais & Al‐Awthan, 2021 ). Cholesterol‐lowering medications are used to treat hyperlipidemia, but these medications' detrimental consequences include muscle weakness and liver damage and incur high healthcare costs (Chai et al., 2012 ).…”

Section: Introductionmentioning

confidence: 99%

The effects of plum products consumption on lipid profile in adults: A systematic review and dose–response meta‐analysis

Heydarian,

Tahvilian,

Asbaghi

et al. 2024

Food Science & Nutrition

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Consumption of plum does not yet clearly affect the lipid profile. To ascertain the advantages of plum consumption on adult lipid profiles, we conducted a systematic review and meta‐analysis. We used pertinent keywords to search the databases of PubMed, Scopus, and ISI Web of Science up to November 10th, 2022, in order to find trials that were eligible. According to the analyses, eating plum significantly lowers LDL levels compared to controls (WMD: −12.50 mg/dL, 95% CI: −22.06, −2.94, p = .010). Although plum consumption did not result in significant changes in TG (WMD: 0.56 mg/dL, 95% CI: −6.02, 7.15, p = .866), TC (WMD: −12.35 mg/dL, 95% CI: −25.05, 0.37, p = .057), and HDL concentrations (WMD: −0.39 mg/dL, 95% CI: −4.69, 3.89, p = .855) compared to the control group. Intake of plums, particularly the intervention type of dried plums, significantly decreased TC levels in unhealthy subjects, according to subgroup analysis. The consumption of plums had a notably statistically significant effect on LDL levels when the intervention type was dried plum and unhealthy subjects were enrolled. Due to the very low to moderate quality of meta‐evidence, to show how eating plum improves lipid profile, further high‐quality research are still essential.

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Khat Chewing and Lipid Profile in Human and Experimental Animals

Cited by 4 publications

References 54 publications

Glycemic effects of <em>Catha edulis</em>

Glycemic effects of <em>Catha edulis</em>

Khat (Catha edulis) as a risk factor for cardiovascular disorders: Controversies and facts

The effects of plum products consumption on lipid profile in adults: A systematic review and dose–response meta‐analysis

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