Ki-1 (CD30) Positive anaplastic large cell lymphoma of T-cell phenotype developing in association with long-standing tuberculous pyothorax: Report of a case with detection of Epstein-Barr virus genome in the tumor cells

Nakamura, Shigeo; Sasajima, Yasushi; Koshikawa, Takashi; Kitoh, Kuniyoshi; Kato, Masahito; Ueda, Ryuzo; Mori, Shigeki; Suchi, Taizan

doi:10.1016/0046-8177(95)90306-2

Cited by 25 publications

(10 citation statements)

References 6 publications

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“…Epidemiological studies carried out in Japan have suggested that the risk of lymphoma in these patients is 3,000 times higher than for the general population [14]. PAL is characterized by a singular or plurinodular mass infiltrating the pleura and the chest wall, in the absence of any other nodal or extranodal location, and most often displays the features of diffuse peripheral large B-cell lymphoma immunoblastic, although exceptional cases with anaplastic large-cell [12] orT-cell-rich B-cell morphology [24] have also been described. So far, immunohistochemistry has shown Bor null-phenotype in all but two cases, which revealed hybrid [25] and T-cell natures [12], respectively.…”

Section: Discussionmentioning

confidence: 99%

“…PAL is characterized by a singular or plurinodular mass infiltrating the pleura and the chest wall, in the absence of any other nodal or extranodal location, and most often displays the features of diffuse peripheral large B-cell lymphoma immunoblastic, although exceptional cases with anaplastic large-cell [12] orT-cell-rich B-cell morphology [24] have also been described. So far, immunohistochemistry has shown Bor null-phenotype in all but two cases, which revealed hybrid [25] and T-cell natures [12], respectively. Molecular biology has documented clonal rearrangements of the genes encoding for Ig heavy chains and p53 mutations, most of them at dipyrimidine sites [7].Virological studies suggest a causal relationship with EBV, but not HHV8, which is usually found in primary effusion lymphomas [5,7,[13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…It presents with pleural effusion, one or more masses, and possible infiltration of the parietal and visceral pleura. The neoplastic cells are large and usually display immunoblastic morphology [6,7]; in most instances immunohistochemistry reveals B-cell or nullphenotype and CD30 negativity [6,7], while hybrid or T-cell phenotype and CD30 expression have seldom been reported [12]. Molecular biology documents frequent monoclonal Ig gene rearrangements [7].…”

Section: Introductionmentioning

confidence: 99%

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Pyothorax-associated lymphoma: Description of the first two cases detected in Italy

Ascani¹,

Piccioli²,

Poggi³

et al. 1997

Annals of Oncology

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SummaryBackground: Pyothorax-associated lymphoma (PAL) is a rare, but distinct, clinico-pathologic entity which occurs most often in Japanese people; to the best of our knowledge, only six cases of it have been reported in Western countries. The tumour develops several decades following artificial pneumothorax or chronic pleuritis due to tuberculous infection, produces pleural effusion associated with extensive local lymphomatous infiltrates, and is sustained by a polymorphic large B-cell clonal proliferation showing EBV integration in the genoma of the neoplastic cells.Patients and methods: Herein we describe two cases of PAL observed in Italian patients, both extensively studied on the clinical, pathological, phenotypic, virological, and molecular levels.Results: The two cases occurred, respectively, 45 and 50 years after therapeutic pneumothorax because of tuberculous pleuritis and were characterized by a pleural mass extending to the thoracic wall, which on histological examination were seen to consist of large elements with immunoblastic morphology.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pyothorax-associated lymphoma: Description of the first two cases detected in Italy

Ascani¹,

Piccioli²,

Poggi³

et al. 1997

Annals of Oncology

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“…21 Although rare cases of anaplastic large cell and T cell rich B cell morphology have been described, our cases were representative of the more usual diVuse large B cell immunoblastic phenotype, and both demonstrated clonal rearrangements ( and light chain restriction), as documented previously. 12 22 23 The Ki-67 index was high (80-90% of cells positive), indicating high cell turnover.…”

Section: Discussionmentioning

confidence: 99%

Expression profile of human herpesvirus 8 (HHV-8) in pyothorax associated lymphoma and in effusion lymphoma

O'Donovan

Silva

Uhlmann

et al. 2001

Molecular Pathology

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“…Karakas et al have reported 14 patients with Hodgkin lymphoma in whom tuberculosis preceded the diagnosis of malignancy in 3 of them, the diagnosis was set at the same time in 2; in 7 of them the infection was diagnosed while on chemotherapy and in 2 after the cessation of lymphoma treatment [27]. Nevertheless, an adult case has been reported with coexistence of ALCL (Ki-1 positive expression) and tuberculous pyothorax [31]. …”

Section: Discussionmentioning

confidence: 99%

Successful Treatment in a Child with Anaplastic Large Cell Lymphoma and Coexistence of Pulmonary Tuberculosis

Baka

Doganis

Pourtsidis

et al. 2013

Case Reports in Pediatrics

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A 13-year-old girl was admitted to our department with a history of severe pain of her left axilla and fever. On physical examination, a block of lymph nodes in her left axilla, diffuse papular rash, and red-violet swelling of her supraclavicular and subclavian region were noted. Imaging investigations revealed left axillar and supraclavicular lymphadenopathy and a small nodular shade in the upper lobe of her left lung. A biopsy from an axillary lymph node established the diagnosis of anaplastic large cell lymphoma (ALCL), whereas DNA of Mycobacterium tuberculosis was detected by polymerase chain reaction (PCR) in the same tissue biopsy. Patient was started on chemotherapy for ALCL and achieved remission of all initially involved fields. Nevertheless, two new nodular lesions were detected in the left lower lobe. Biopsy revealed granulomas, and PCR was positive for M. tuberculosis. Our patient received treatment with the combination of isoniazid and rifampin (12 months), pyrazinamide (the first 2 months), and maintenance chemotherapy for her ALCL for one year simultaneously. Four years later, she is disease free for both mycobacterial infection and lymphoma. We are reporting this successful management of mycobacterial infection in a patient with ALCL despite intensive chemotherapy that the patient received at the same time.

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Ki-1 (CD30) Positive anaplastic large cell lymphoma of T-cell phenotype developing in association with long-standing tuberculous pyothorax: Report of a case with detection of Epstein-Barr virus genome in the tumor cells

Cited by 25 publications

References 6 publications

Pyothorax-associated lymphoma: Description of the first two cases detected in Italy

Pyothorax-associated lymphoma: Description of the first two cases detected in Italy

Expression profile of human herpesvirus 8 (HHV-8) in pyothorax associated lymphoma and in effusion lymphoma

Successful Treatment in a Child with Anaplastic Large Cell Lymphoma and Coexistence of Pulmonary Tuberculosis

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