Ki-67 and c-jun expression in pancreatic cancer: a prognostic marker?

Ferrara, C.; Tessari, G; Poletti, Anna; Giacon, Claudia; Meggiato, T.; Martines, D.; Favero, G. Del; Naccarato, R.

doi:10.3892/or.6.5.1117

Cited by 21 publications

(25 citation statements)

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“…Previous report demonstrated that Ki-67 expression in pancreatic cancer was the most important determinant of long-term survival 18. Additionally, we found tumour differentiation and LAT1 expression were thought to be individual prognostic factors (table 1).…”

Section: Discussionsupporting

confidence: 62%

High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas

et al. 2012

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Section: Discussionsupporting

confidence: 62%

High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas

et al. 2012

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“…However, neither a decrease of MUC6 expression in secondary lesions in comparison to primary tumours [46], nor an increase of Ki67 proliferative index in metastases [58,59] was confirmed in this study. In the present series MUC6 expression was rare in both primary and secondary lesions.…”

Section: Concordance Of Protein Expression Patterns In Primary and Sesupporting

confidence: 69%

“…Among IHC markers examined by other investigators in primary and metastatic PDAC and listed in the Results section, only 9 antigens (corresponding genes: EPHA2, MAP2K4, MKI67, MUC2, MUC5B, MUC6, TYMP, and 2 mucin antigens: T on MUC1, Tn/STn on MUC1) showed a statistically significant difference in extent and/or intensity of IHC staining in matched or non-matched samples of primary PDAC tissues and distant metastases [46,[56][57][58][59]. However, neither a decrease of MUC6 expression in secondary lesions in comparison to primary tumours [46], nor an increase of Ki67 proliferative index in metastases [58,59] was confirmed in this study.…”

Section: Concordance Of Protein Expression Patterns In Primary and Sementioning

confidence: 99%

Ductal adenocarcinoma of the pancreas usually retained SMAD4 and p53 protein status as well as expression of epithelial-to-mesenchymal transition markers and cell cycle regulators at the stage of liver metastasis

Liszka¹

2014

pjp

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There are limited data on the biology of metastatic pancreatic ductal adenocarcinoma (PDAC). The aim of the present study was to compare the expression of immunohistochemical markers that may be involved in the development of metastatic disease in primary PDAC and in synchronous liver metastatic tissues. Thirty-two stains (corresponding to proteins encoded by 31 genes: SMAD4, TP53, ACTA2, CDH1, CDKN1A, CLDN1, CLDN4, CLDN7, CTNNB1, EGFR, ERBB2, FN1, KRT19, MAPK1/MAPK3, MAPK14, MKI67, MMP2, MMP9, MUC1 (3 antibodies), MUC5AC, MUC6, MTOR, MYC, NES, PTGS2, RPS6, RPS6KB1, TGFB1, TGFBR1, VIM)were evaluated using tissue microarray of 26 pairs of primary PDACs and their liver metastases. There were no significant differences in expression levels of examined proteins between primary and secondary lesions. In particular, metastatic PDAC retained the primary tumour's SMAD4 protein status in all and p53 protein status in all but one case. This surprising homogeneity also involved expression levels of markers of epithelial-to-mesenchymal transition as well as cell cycle regulators studied. In conclusion, the biological profiles of primary PDACs and their liver metastases seemed to be similar. Molecular alterations of PDAC related to a set of immunohistochemical markers examined in the present study were already present at the stage of localized disease.

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“…The 8 patients with a low expression survived significantly longer than the 15 patients with a high expression (p = 0.0216). Takahashi/Oda/Hasebe/Sasaki/Kinoshita/ Konishi/Ueda/Nakahashi/Ochiai/Ochiai to be prognostic factors in cases with pancreatic ductal carcinoma [10][11][12][13][14][15][16][17]. However, only a few studies focused on elucidating the mechanisms underlying the development of liver metastasis in cases of pancreatic cancer [20][21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, several clinicopathological factors such as the tumor size, histological grade of differentiation, status of nodal involvement, and the expression of VEGF, p53 and Ki-67 have been reported to be correlated with the overall survival of pancreatic cancer patients [10][11][12][13][14][15][16][17]. However, controversial results have been reported on the predictive value of these factors.…”

Section: Introductionmentioning

confidence: 99%

Overexpression of Sialyl Lewis x Antigen Is Associated with Formation of Extratumoral Venous Invasion and Predicts Postoperative Development of Massive Hepatic Metastasis in Cases with Pancreatic Ductal Adenocarcinoma

Takahashi¹,

Oda²,

Hasebe³

et al. 2001

Pathobiology

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The clinicopathological factors and expression of sialyl Lewis antigens which are the cell adhesion molecules to endothelial cells were compared in relation to the extent of the postoperative hepatic metastasis in 23 consecutive patients with pancreatic ductal adenocarcinoma whose clinical courses were carefully monitored and documented. The overall survival of cases with massive hepatic metastasis (MHM) was significantly poorer than that of those with local or no hepatic metastasis (p = 0.0453). Postoperative MHM was significantly correlated with the presence of duodenal invasion (p = 0.0418), the presence of portal vein invasion (p = 0.0435), the presence of extratumoral venous invasion (p = 0.0052) and high expression of sialyl Lewis x antigen (p = 0.0022). Multivariate analysis confined significant correlation between the high expression of sialyl Lewis x antigen and the development of MHM (p = 0.0402). Kaplan-Meier analysis revealed that the overall survival of patients with a high expression of sialyl Lewis x antigen was significantly poorer than that of patients with a low expression of the antigen (p = 0.0216). These results indicate that the overexpression of sialyl Lewis x antigen plays an important role in the development of MHM, and also predicts a poorer overall survival of these patients. Further studies with more cases are warranted to confirm these results.

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Ki-67 and c-jun expression in pancreatic cancer: a prognostic marker?

Cited by 21 publications

References 0 publications

High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas

High expression of L-type amino acid transporter 1 (LAT1) predicts poor prognosis in pancreatic ductal adenocarcinomas

Ductal adenocarcinoma of the pancreas usually retained SMAD4 and p53 protein status as well as expression of epithelial-to-mesenchymal transition markers and cell cycle regulators at the stage of liver metastasis

Overexpression of Sialyl Lewis x Antigen Is Associated with Formation of Extratumoral Venous Invasion and Predicts Postoperative Development of Massive Hepatic Metastasis in Cases with Pancreatic Ductal Adenocarcinoma

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