Kidney Cancer Linked to Chronic Hepatitis in the Asia-Pacific: A Population-Based Analysis

Lin, Yu Shan; Yeh, Chih Ching; Lin, Yong-Song; Su, Chien Tien; Sung, Fung Chang; Chang, Shih Ni; Liu, Yun Ru; Su, Fu Hsiung

doi:10.1159/000453045

Cited by 10 publications

(22 citation statements)

References 36 publications

(36 reference statements)

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“…First, compared with persons of eGFR ≥ 90 ml/min/1.73m 2 , those of eGFR < 60 ml/min/1.73m 2 tended to have more risk factors of cancer, such as older age, smoking, obesity and diabetes 18 . Second, CKD and cancer have common risk factors, such as virus and herbal medicines including aristolochine, which have both nephrotoxic effects and carcinogenic activity 19 , 20 . Third, the retention of uremic toxins could result in immunosuppression, which contribute to the development of cancer, and further accentuate mitogenesis and proliferation in malignant tumors.…”

Section: Discussionmentioning

confidence: 99%

Association between kidney function and the risk of cancer: Results from the China Health and Retirement longitudinal study (CHARLS)

Liu¹,

Zhu²,

Meng³

et al. 2020

J. Cancer

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Objective: Increased cancer risk after dialysis or transplantation has been recognized, but studies of cancer in pre-dialysis chronic kidney disease (CKD) are extremely limited. Therefore, we aim to investigate the risk of cancer in individuals with reduced kidney function. Methods: This study was based on China Health and Retirement Longitudinal Study (CHARLS), a nationally representative population aged ≥ 45 years old. We included 11 508 (5364 male) individuals with measurement of serum creatinine and without history of cancer at baseline. Incident cancer cases were documented in the biennial questionnaire. Results: The mean age was 58.7 ± 9.8 years. Participants with estimated glomerular filtration rate (eGFR) ≥ 90 ml/min/1.73m 2 , 60 to 89 ml/min/1.73m 2 , and eGFR < 60 ml/min/1.73m 2 accounted for 62.9%, 33.7% and 3.4%, respectively. During 42 895 person-years' follow-up, 217 new cases of cancer were recorded. In participants with eGFR < 90 ml/min/1.73m 2 , cubic spline showed linear relationship between the risk of cancer and eGFR, while remained stable and no association in participants with eGFR > 90 ml/min/1.73m 2. Compared to participants with eGFR ≥ 90 ml/min/1.73m 2 , those with eGFR < 60 ml/min/1.73m 2 was associated with the increased risk of cancer in the fully adjusted model (hazard ratio 2.08; 95% confidence interval 1.22-3.53); and the risk for kidney and lung cancers was higher among those with eGFR < 60 ml/min/1.73m 2. Conclusion: Reduced kidney function is associated with a higher risk of cancer and should be integrated into risk-stratification of cancer screening and management.

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Section: Discussionmentioning

confidence: 99%

Association between kidney function and the risk of cancer: Results from the China Health and Retirement longitudinal study (CHARLS)

Liu¹,

Zhu²,

Meng³

et al. 2020

J. Cancer

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“…A total of 644 studies using the search criteria were identi ed. Finally, we extracted 12 studies [8][9][10][11][12][13][14][15][16][17][18][19] based on the eligible criteria ( Supplementary Fig. S1).…”

Section: Resultsmentioning

confidence: 99%

The Association Between Hepatitis C Virus Infection and Renal Cell Cancer, Prostate Cancer, and Bladder Cancer: A Systematic Review and Meta-Analysis

Jian¹,

Ma²,

Li³

et al. 2020

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Background: To update the current evidence on whether hepatitis C virus (HCV) infection represents a possible risk factor for renal cell cancer (RCC), prostate cancer (PCa) and bladder cancer (BC). Methods: We searched literatures on Pubmed, Web of Science and Embases before February 2020. A systematic review and meta-analysis were performed. Results: Finally, we extracted 12 studies based on the eligible criteria. Across 11 studies for HCV and RCC, the incorporated RR was 1.28 (95% CI 1.05-1.55), which meant that participants with HCV infection were associated with a higher risk of RCC. The pooled RR in hazard ratio (HR) subgroup (HR 1.59, 95% CI 1.22-2.08), cohort studies (CS) subgroup (RR 1.47, 95% CI 1.18-1.82), and North America subgroup (RR 1.71, 95% CI 1.40-2.09) detected a stronger association between HCV and RCC risk. Although an inverse association was seen for PCa (RR 0.75, 95% CI 0.54-1.03) across 7 studies, it was not statistically signi cant (P = 0.075). There was no signi cant association between HCV and BC with an incorporated RR of 0.92 (95% CI, 0.82-1.03) across 5 studies. Conclusions: Our study demonstrated that HCV infection was signi cantly associated with increased RCC risk. There appeared to be an inverse association for HCV in PCa risk but no statistically signi cant. No signi cant association was found between HCV and BC risk. Prospective, large-scale and well-designed cohort studies are required to validate the association between HCV and RCC, and to investigate the role of HCV on PCa.

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“…It is currently thought that the virus, host and genetic factors interact and lead to kidney damage. The antigen composition in the kidney deposition increased with a large number of HBV‐DNA replication, which leading to a variety of inflammatory cells and media activation and mobilization to strengthen, eventually leading to increased renal pathological damage …”

Section: Discussionmentioning

confidence: 99%

Analysis of clinical features and pathology of serum HBsAg positive glomerulonephritis

Peng

Xie

Liu

et al. 2017

Journal of Medical Virology

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To analyze the relationship between the factors related to the occurrence of HBV-GN and serum HBsAg-positive glomerulonephritis. A total of 56 patients were enrolled in the present study. All enrolled cases were divided into two groups according to whether HBsAg and/or HBcAg was present in renal kidney tissue: patients with Hepatitis B virus-associated nephritis (HBV-GN group, 30 cases) and patients with hepatitis B virus-combined nephritis (HBV-CG group, 26 cases). We sought to analyze the differences in clinical features and pathological characteristics in both groups. The rate of HBeAg positivity in the HBV-GN group was considerably increased in the HBV-CG group (P < 0.05), and the number of patients with HBsAg+HBeAg+HBcAb+ in the HBV-GN group was considerably increased in the HBV-CG group (21 cases vs 10 cases) (P < 0.05). Moreover, the number of MCD patients diagnosed by renal biopsy in the HBV-GN group was reduced compared with the HBV-CG group (1 case vs 7 cases) (P < 0.05). HBV infection and high-virus proliferation status were closely related with HBV-GN.

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Kidney Cancer Linked to Chronic Hepatitis in the Asia-Pacific: A Population-Based Analysis

Cited by 10 publications

References 36 publications

Association between kidney function and the risk of cancer: Results from the China Health and Retirement longitudinal study (CHARLS)

Association between kidney function and the risk of cancer: Results from the China Health and Retirement longitudinal study (CHARLS)

The Association Between Hepatitis C Virus Infection and Renal Cell Cancer, Prostate Cancer, and Bladder Cancer: A Systematic Review and Meta-Analysis

Analysis of clinical features and pathology of serum HBsAg positive glomerulonephritis

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