Kidney complications of parasitic diseases

Daher, Elizabeth De Francesco; Silva, Geraldo Bezerra da; Trivedi, Mayuri; Fayad, Tarek; Srisawat, Nattachai; Nair, Sanjeev; Siriyasatien, Padet; Lacerda, Marcus Vinícius Guimarães; Baptista, Maria Alice Sperto Ferreira; Vankalakunti, Mahesha; Jha, Vivekanand

doi:10.1038/s41581-022-00558-z

Cited by 18 publications

(7 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, when immunity is weakened by diseases such as CKD or treatment with immunosuppressive drugs, the parasite can quickly multiply, which causes hyperinfection and potentially fatal disseminated strongyloidiasis [ 17 ]. Strongyloides - or helminth-associated glomerulopathy could be due to direct parasite damage, immunological phenomena, and systemic manifestations [ 18 ]. There are several reports of an association between this infection and nephrotic syndrome and minimal-change disease [ 19 , 20 ] as well as alteration of the gut microbiome [ 14 , 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Strongyloides stercoralis infection reduces Fusicatenibacter and Anaerostipes in the gut and increases bacterial amino-acid metabolism in early-stage chronic kidney disease

Tran,

Chaidee,

Surapinit

et al. 2023

Heliyon

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Strongyloides stercoralis infection reduces Fusicatenibacter and Anaerostipes in the gut and increases bacterial amino-acid metabolism in early-stage chronic kidney disease

Tran,

Chaidee,

Surapinit

et al. 2023

Heliyon

View full text Add to dashboard Cite

“…In the current study, the incidence of renal dysfunction was con rmed through elevated levels of serum creatinine and urea in the untreated group. Such dysfunctions are connected with fatal complications in malaria, contributing to high morbidity and mortality [116,119]. The antioxidant potential of EcASBE with its ability to scavenge initiators of lipid peroxidation, preserving the structural integrity of the kidney membrane and enhances renal function, are demonstrated by the improvement in serum creatinine and urea levels of the EcASBE-treated groups.…”

Section: Discussionmentioning

confidence: 99%

Aqueous extract of Enantia chlorantha Oliv. demonstrates antimalarial activity and improves redox imbalance and biochemical alterations in mice

Evbuomwan,

Adeyemi,

Oluba

2024

Preprint

View full text Add to dashboard Cite

Background: Malaria is an infectious oxidative disease, which has continued to cause inconceivable loss of lives every year, almost unabatedly. Currently, it has become more difficult to treat the disease due the emergence and spread of resistance to recommended antimalarial drugs including ACTs, necessitating an urgent search for antimalarial compounds with unique modes of action. Here, we investigated the antimalarial activity, antioxidant and antiinflammatory capacity of Enantia chlorantha aqueous stem bark extract (EcASBE) in vivo. Methods: The extract was screened for selected phytoconstituents including alkaloids and flavonoids. We evaluated the antimalarial activity of EcASBE against Plasmodium berghei NK65 infection in mice, using curative, prophylactic, and suppressive antimalarial test models, respectively. In addition, the antioxidant and antiinflammatory activities of the extract were assessed. Results: The EcASBE significantly (p < 0.05) inhibited parasitaemia dose-dependently, with the highest inhibition (80.4%) and prolonged survival (MST=20) observed in the curative test. Our findings reveal significant (p < 0.05) improvement of serum ALT, AST, ALP, GGT, and levels of TNF-α, creatinine and urea following extract administration. Furthermore, the extract led to a significant (p < 0.05) rise in the levels of CAT, SOD, GPx, and GSH, with a concomitant reduction in NO and MDA levels. Conclusion: The antimalarial, antioxidative, antiperoxidative, and inflammatory-inhibiting properties of the plant in infected mice demonstrate its great value for therapeutic intervention, and substantiate its use in traditional medicine for malaria treatment. Hence, further investigation to identify the repertoire of the active antimalarial components is warranted.

show abstract

“…Direct Leishmania -induced renal damage mainly results from immunological phenomena, such as the deposition of immune complexes, activation of T cells, up-regulation of adhesion molecules, inflammatory processes, but can also be caused by parasite proliferation in the kidney tissue [ 54 , 55 ] Beside VL, the other causes that can contribute to the development of renal damage in VL patients are drug toxicity, presence of associated infections and haemodynamic abnormalities [ 51 , 53 , 56 ]. Histological examination of graft biopsies in KT recipients with VL is seldom described (Table 1 ); findings range from the absence of parasites [ 39 ] to diffuse interstitial inflammation and abundant parasites [ 35 ] to complete occlusion of renal vasculature [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Updated diagnosis and graft involvement for visceral leishmaniasis in kidney transplant recipients: a case report and literature review

et al. 2022

View full text Add to dashboard Cite

Purpose Visceral leishmaniasis (VL) has become a rising concern to transplantation teams, being associated with graft dysfunction and reduced survival of renal transplant recipients. Here, we describe a case of VL occurring in a kidney transplant (KT) recipient in Italy, a country in which Leishmania infantum is endemic and we reviewed the literature on the clinical course and diagnosis of VL in KT recipients residing or travelling to southern Europe. Results The VL case was diagnosed 18 months after transplant and 28 days after the onset of symptoms by quantitative PCR (qPCR) on peripheral blood. A graft biopsy showed renal involvement, and PCR performed on graft tissue displayed the presence of Leishmania DNA. The retrospective confirmation of Leishmania-positive serology in a serum sample collected before transplantation, as well as the absence of anti-Leishmania IgG in the graft donor strongly suggest that reactivation of a latent parasitic infection caused VL in the current case. Conclusion VL is often underdiagnosed in transplant recipients, despite the presence of latent Leishmania infection being reported in endemic countries. This case report, as well as the literature review on leishmaniasis in KT recipients, underline the importance of rapid VL diagnosis to promptly undergo treatment. Serology is scarcely sensitive in immunocompromised patients, thus molecular tests in peripheral blood should be implemented and standardized for both VL identification and follow-up.

show abstract

Kidney complications of parasitic diseases

Cited by 18 publications

References 99 publications

Strongyloides stercoralis infection reduces Fusicatenibacter and Anaerostipes in the gut and increases bacterial amino-acid metabolism in early-stage chronic kidney disease

Strongyloides stercoralis infection reduces Fusicatenibacter and Anaerostipes in the gut and increases bacterial amino-acid metabolism in early-stage chronic kidney disease

Aqueous extract of Enantia chlorantha Oliv. demonstrates antimalarial activity and improves redox imbalance and biochemical alterations in mice

Updated diagnosis and graft involvement for visceral leishmaniasis in kidney transplant recipients: a case report and literature review

Contact Info

Product

Resources

About