Kidney Damage in the Golden Hamster Following Chronic Administration of Diethylstilbestrol and Sesame Oil.

Matthews, V. S.; Kirkman, Hadley; Bacon, Robert L.

doi:10.3181/00379727-66-16033p

Cited by 69 publications

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“…These experiments on the induction of renal tumours in the male golden hamster by prolonged stilboestrol administration confirm the results previously obtained by Matthews, Kirkman and Bacon (1947), and Kirkman and Bacon (1949). Detailed studies of the histogenesis of these tumours reveal that they arise by progressive hyperplasia of the cortical tubular epithelium, rapidly enlarge and grow not only by expansion but also by peripheral infiltration.…”

Section: Microscopic Descriptionsupporting

confidence: 90%

“…Matthews, Kirkman and Bacon (1947) were the first to demonstrate that the kidneys of the male golden hamster (Cricetus auratus) are the exception as they possess a peculiar susceptibility to renal neoplasia following treatment with oestrogen.The object of this communication is primarily to describe the histogenesis of these oestrogen-induced renal tumours in the male hamster, and to discuss other related problems which might help towards a better understanding of oestrogenic neoplasia. …”

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The Histogenesis of Stilboestrol-Induced Renal Tumours in the Male Golden Hamster

Horning¹,

Whittick²

1954

Br J Cancer

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SEVERAL observers have shown (Pfeiffer, Emmel and Gardner, 1940; Korenchevsky and Ross, 1940) that apart from the occasional production of urinary calculi and glomerulo-nephritis, prolonged oestrogen administration has only a slight effect on the kidneys of rodents, and never induces neoplasia. Matthews, Kirkman and Bacon (1947) were the first to demonstrate that the kidneys of the male golden hamster (Cricetus auratus) are the exception as they possess a peculiar susceptibility to renal neoplasia following treatment with oestrogen.The object of this communication is primarily to describe the histogenesis of these oestrogen-induced renal tumours in the male hamster, and to discuss other related problems which might help towards a better understanding of oestrogenic neoplasia. MATERIAL AND METHODS.Forty male golden hamsters, all approximately 12 weeks of age, each received a 20 mg. pellet of pure diethylstilboestrol subcutaneously in their right flank. An equal number of untreated male hamsters of the same group were kept as controls.For routine histological study the kidneys were fixed in alcoholic Bouin, and subsequently stained either in haematoxylin and eosin or by a modification of Masson's light green. In order to test for the presence of intracellular lipids, both fresh and formalin-fixed kidneys were stained with alkaline Sudan IV, Sudan black B and Nile blue sulphate. The pituitaries were fixed in Zenkerformol and differentially stained by Mallory's triple stain. Verhoeff's method was used for the staining of elastic fibres and the Gordon and Sweet procedulre for the presence of reticulin.OBSERVATIONS. Macroscopic description of renal turnours.Six and a half months after stilboestrol treatment had commenced all hamnsters were palpated weekly for the presence of kidney lesions.Although no renal tumours were palpable at this early period of treatment 8 hamsters were killed in order to study the development of early tumour formation. Each of these hamsters possessed very small cortical lesions which varied between 2 and 5 mm. in diameter. Small palpable tumours arose in some hamsters at the end of the 9th month of treatment, and by the beginning of the 11th month every treated hamster had large renal tumours. At the end of the 12th month

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Section: Microscopic Descriptionsupporting

confidence: 90%

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The Histogenesis of Stilboestrol-Induced Renal Tumours in the Male Golden Hamster

Horning¹,

Whittick²

1954

Br J Cancer

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“…In the male golden hamster, renal tumours may be produced by chronic oestrogen administration (Matthews et al, 1947;Kirkham and Robbins, 1959), the histological pattern of this tumour being similar to that of human renal tumours (Horning and Whittick, 1954). Both testosterone and progestogens inhibit the production and growth of the tumour; it may be transplanted into the male hamsters which have been oestrogen sensitised, and progestogen may inhibit the growth rate of the transplanted tumour.…”

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The Use of Progestogen in the Treatment of Metastatic Carcinoma of the Kidney and Uterine Body

Ch¹,

Fw²,

Ellis³

1970

Br J Cancer

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SUMMARY.-The effect of the progestogen medroxyprogesterone acetate on metastases from renal, endometrial and other tumours has been studied in 25 patients. Seven patients with renal and endometrial tumours had a useful response, pulmonary metastases and a large primary renal tumour showing the greatest effect. Bony metastases were unaffected by the drug and were treated by local radiotherapy. If a response occurred, it did so within 3 months.IT has been known for several years that the growth of some tumours may be influenced by hormones. Breast tumours will often respond to hormone treatment or to endocrine gland ablation. Briggs et al. (1967) summarised work on the responses of tumours of women, such as those of the breast, endometrium, ovary and cervix, to various progestogens and found an overall response rate of 280%.Renal tumours, which are somewhat more common in males than females, may have endocrine effects, such as polycythaemia and hypertension, due to the release of erythropoietin or renin into the circulation. In the male golden hamster, renal tumours may be produced by chronic oestrogen administration (Matthews et al., 1947;Kirkham and Robbins, 1959), the histological pattern of this tumour being similar to that of human renal tumours (Horning and Whittick, 1954). Both testosterone and progestogens inhibit the production and growth of the tumour; it may be transplanted into the male hamsters which have been oestrogen sensitised, and progestogen may inhibit the growth rate of the transplanted tumour. Cortisone may also have a cancericidal effect, and when given with progestogen in these animals produced almost complete inhibition of tumour growth . Bloom (1964) tried the combination of testosterone and progestogen in 3 patients and corticosteroid treatment in 7 patients with metastatic renal adenocarcinoma without effect, and in another patient progestogen appeared to cause the mastastases to increase whilst testosterone caused them to regress (Bloom and Wallace, 1964). Since then, further trials on patients have taken place. Bloom (1967) reported the effects of steroid treatment in 38 patients (21 men and 17 women) with incurable renal adenocarcinoma and multiple metastases. Of these, 32 had more than one organ involved and 23 were seriously ill or " terminal " when hormone therapy was instituted. In 10 the liver was enlarged, 2 had cerebral metastases, 13 had skeletal deposits and 24 had pulmonary or mediastinal lesions. Six men and 2 women had marked regression of their tumours and

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“…OBSERVATIONS conlceriiing the stilboestrol-induced renial tumour ini the Syriani golden hamster, first described by Matthews, Kirkman and Bacon (1947), have been presented in a series of communications by Kirkman and Bacon (1949, 1952a, 1952b, Horning (1952Horning ( , 1954Horning ( , 1956aHorning ( , 1956b, Horning and Whittick (1954), Kirkman (1959). These data have been reviewed and extended by Bloom, Dukes and Mitchley (1963) who considered the characteristics of the primary and transplanted tumours, described factors influencing tumour development and subsequent growth, and discussed the histogenesis and possible mechanism of tumour induction.…”

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Hormone-Dependent Tumours of the Kidney

Bloom¹,

Baker²,

Dukes³

et al. 1963

Br J Cancer

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Kidney Damage in the Golden Hamster Following Chronic Administration of Diethylstilbestrol and Sesame Oil.

Cited by 69 publications

References 0 publications

The Histogenesis of Stilboestrol-Induced Renal Tumours in the Male Golden Hamster

The Histogenesis of Stilboestrol-Induced Renal Tumours in the Male Golden Hamster

The Use of Progestogen in the Treatment of Metastatic Carcinoma of the Kidney and Uterine Body

Hormone-Dependent Tumours of the Kidney

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