Kidney Dimensions at Sonography are Correlated With Glomerular Filtration Rate in Renal Transplant Recipients and in Kidney Donors

Paleologo, G; Abdelkawy, Hesham M H; Barsotti, M; Basha, A. Alavudeen; Bernabini, Giada; Bianchi, Andrea; Caprio, Francesca; Emad, Ali; Grassi, G; Nerucci, B; Tregnaghi, C.; Rizzo, G; Donadio, Carlo

doi:10.1016/j.transproceed.2007.05.003

Cited by 28 publications

(30 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Renal length was chosen as the dependent variable from other ultrasongraphic measurements such as renal volume and cortical thickness because renal length has the least amount of inter-observer variation and has been established to correlate with GFR. 24,34 Compared to published healthy controls, most age groups in the MMA cohort had significantly smaller renal lengths (Table 1). The healthy control group and the MMA group both had similar constants (y-intercept), 6.79 and 6.80 respectively, suggesting that kidney size was normal at birth in the MMA patients; however, the slope (cm/year) of kidney length increase in the MMA group was less than half that of the controls: 0.09 cm/year versus 0.22 cm/year.…”

Section: Discussionmentioning

confidence: 92%

Renal growth in isolated methylmalonic acidemia

Kruszka

Manoli

Sloan

et al. 2013

Genetics in Medicine

View full text Add to dashboard Cite

Purpose We sought to predict renal growth based on clinical and metabolic parameters in patients with isolated methylmalonic acidemia (MMA), a group of disorders associated with chronic kidney disease. Methods Fifty MMA patients, followed from 2004 to 2011, were classified by molecular genetics and studied using a combined cross-sectional and longitudinal design that included renal ultrasound examinations, anthropometric measurements, and metabolic phenotyping. Renal length was compared to healthy controls and modeled to other clinical parameters using multiple regression analyses. Results Comparisons with age-matched controls showed that renal length in MMA subjects was significantly decreased (p < 0.05). Stepwise regression modeling found that combinations of height, serum cystatin C, and serum methymalonic acid concentrations best predicted kidney size. The regression equations used to generate MMA kidney nomograms were: renal length (cm) = 6.79 + 0.22 * age for the controls and 6.80 + 0.09 * age for the MMA cohort (p < 0.001; constant and slope). Conclusions Renal length, reflective of kidney growth, significantly decreased in MMA patients over time compared to controls and was predictable with select clinical parameters. Cystatin C and serum methylmalonic acid concentrations were highly correlated with smaller kidneys and decreased renal function in this patient population.

show abstract

Section: Discussionmentioning

confidence: 92%

Renal growth in isolated methylmalonic acidemia

Kruszka

Manoli

Sloan

et al. 2013

Genetics in Medicine

View full text Add to dashboard Cite

show abstract

“…Similarly, total kidney volume, parenchymal renal volume and even length using ultrasound have also been shown to correlate with measured GFR (again assessed only at baseline) among potential living donors, actual donors and recipients [15, 29, 30], although others have not demonstrated a significant relationship between kidney volume and baseline eGFR [31]. Most studies did not examine the relationship of kidney size and kidney function over time (post-operatively or longer-term), and they did not adjust kidney size for patient size.…”

Section: Discussionmentioning

confidence: 99%

“…Transplant donor's size (length, weight or volume) is often cited as a predictive factor for recipient allograft function [15–17] but likely also predicts donor outcomes including donor kidney function [18]. Recent publications seem to favor total kidney volume [16] or cortical volume [19] in living donor transplantation.…”

Section: Introductionmentioning

confidence: 99%

Does size matter? Kidney transplant donor size determines kidney function among living donors

et al. 2016

View full text Add to dashboard Cite

BackgroundKidney donor outcomes are gaining attention, particularly as donor eligibility criteria continue to expand. Kidney size, a useful predictor of recipient kidney function, also likely correlates with donor outcomes. Although donor evaluation includes donor kidney size measurements, the association between kidney size and outcomes are poorly defined.MethodsWe examined the relationship between kidney size (body surface area-adjusted total volume, cortical volume and length) and renal outcomes (post-operative recovery and longer-term kidney function) among 85 kidney donors using general linear models and time-to-chronic kidney disease data.ResultsDonors with the largest adjusted cortical volume were more likely to achieve an estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 over a median 24-month follow-up than those with smaller cortical volumes (P <0.001), had a shorter duration of renal recovery (1.3–2.2 versus 32.5 days) and started with a higher eGFR at pre-donation (107–110 versus 91 mL/min/1.73 m2) and immediately post-nephrectomy (∼63 versus 50–51 mL/min/1.73 m2). Similar findings were seen with adjusted total volume and length.ConclusionsLarger kidney donors were more likely to achieve an eGFR ≥60 mL/min/1.73 m2 with renal recovery over a shorter duration due to higher pre-donation and initial post-nephrectomy eGFRs.

show abstract

“…Kidney volume is important for staging of renovascular hypertension, chronic renal insufficiency and transplantation [3,80]. Even more length has been weakly yet constantly and directly correlated with creatinine levels and glomerular filtration rate in transplanted patients, making it an appropriate examination for follow-up of patients with known renal insufficiency [7,71,97,101]. Viscera width and thickness do not present direct clinical importance, yet they are necessary for calculating spleen [68,103] and kidney [23] volume.…”

Section: Discussionmentioning

confidence: 99%