Kidney Diseases: The Age of Molecular Markers

Veiga, Gláucia Luciano da; Alves, Beatriz da Costa Aguiar; Perez, Matheus Moreira; Raimundo, Joyce Regina Santos; Encinas, Jéssica Freitas de Araújo; Murad, Neif; Fonseca, Fernando Luiz Affonso

doi:10.1007/978-3-030-63908-2_2

Cited by 3 publications

(3 citation statements)

References 117 publications

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“…However, kidneys are organs that play an important role in metabolic activities. The absorption of minerals and water, acid-base balance, and the functionality of buffer systems are regulated by the kidney and are of vital importance [1]. The proteasuria, membranous nephropathy, diabetic nephropathy, complement-mediated-kidneydisease, and other kidney pathologies examined by eminent authors in this book with the aim of opening new horizons.…”

Section: Introductionmentioning

confidence: 99%

Introductory Chapter: An Overview of Nephritis, Nephrotic Syndrome, and Nephrosis

Çiçek

2024

Novel Topics in the Diagnosis, Treatment, and Follow-Up of Nephritis, Nephrotic Syndrome, and Nephrosis

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Section: Introductionmentioning

confidence: 99%

Introductory Chapter: An Overview of Nephritis, Nephrotic Syndrome, and Nephrosis

Çiçek

2024

Novel Topics in the Diagnosis, Treatment, and Follow-Up of Nephritis, Nephrotic Syndrome, and Nephrosis

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“…Исходно ОПП -часто сопутствующее состояние у больных острым инфарктом миокарда (ИМ), которое может затруднять и откладывать своевременное проведение основного метода обследования и лечения ОКС вследствие пути элиминации рентгеноконтрастных препаратов через почки [4,5]. По данным метаанализа, в который вошло двадцать пять исследований с участием 254 408 взрослых (55 150 с ОПП), ОПП было ассоциировано с повышением риска сердечно-сосудистой смертности на 86% и серьезных сердечно-сосудистых событий на 38%, а также сердечной недостаточности на 58% и конкретно острого ИМ на 40% [6]. У пациентов с ОПП увеличиваются средний койко-день пребывания в стационаре, частота повторных сердечно-сосудистых событий, в том числе в отдаленном периоде наблюдения [7].…”

Section: Introductionunclassified

Acute kidney injury in patients with myocardial infarction and percutaneous coronary interventions: laboratory markers and the influence on the frequency of recurrent cardiovascular events

Демчук

Sukmanova

2023

Kompleks. probl. serdečno-sosud. zabol.

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Highlights. Biomarkers of acute kidney injury and their effect on the frequency of recurrent coronary events in patients with myocardial infarction after percutaneous coronary interventions.Aim. To study biomarkers of acute kidney injury (AKI) and prognosis, as well as the frequency of recurrent cardiovascular events in patients with myocardial infarction and percutaneous coronary interventions.Methods. 166 patients with myocardial infarction and performed percutaneous coronary interventions were studied, divided into 2 groups: with acute kidney injury (n = 91) and without it (n = 50), the control group consisted of 25 people. All patients underwent standard general clinical and biochemical blood tests to assess the level of C-reactive protein, markers of myocardial necrosis, natriuretic peptide (NTproBNP), microalbuminuria (MAU). In both groups, the glomerular filtration rate (GFR) was calculated using the CKD-EPI formula. An increase in serum creatinine by 26.5 mmol/L or more during the first 3 days from the value at admission was the reason for the study of the level of Kidney Injury Molecule-1 (KIM-1) and interleukin 18 (IL-18) in urine on the 3rd and 14th days from hospitalization. All patients underwent coronary angiography and stenting of the infarct-dependent artery. 6 months and 1 year after discharge for this acute coronary event, repeated examinations of patients were performed to assess the frequency of repeated cardiovascular events and kidney function.Results. It was revealed that the creatinine level in the examined patients did not differ statistically significantly at admission, but there was a decrease in the filtration function of the kidneys in patients with AKI. On the third day of hospitalization, there was an increase in creatinine levels in the first group of patients with a decrease in GFR. The level of the KIM-1 and IL-18 molecules on the 3rd day of hospitalization in the first group was higher than the corresponding indicator of the comparison group. Also, patients with AKI showed a significant increase in the level of NTproBNP and MAU in the early period of kidney damage. When studying correlations, it was revealed that the level of MAU in the group with AKI is interrelated with the indicator of C-reactive protein and creatinine on the 3rd day of hospitalization. Also, a positive statistically significant correlation was found between the level of the KIM-1 molecule, IL-18, creatinine level on the 3rd day of hospitalization, NTproBNP and the level of MAU. During the follow-up of patients 6 months and a year after discharge, unstable angina pectoris, myocardial infarction, as well as progression of chronic heart failure were more often detected in the group with AKI. A persistent decrease in kidney function after a year was observed in most patients of the first group.Conclusion. The data obtained indicate the influence of acute kidney injury on the progression of renal dysfunction and the frequency of recurrent cardiovascular events, which is confirmed by the obtained associative relationships of the level of the KIM-1 molecule, creatinine and GFR with the prognosis of cardiovascular disease.

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“…Among the advances of the last decades, referring to the diagnosis and prognosis of this disease, there was an understanding of the pathophysiological processes and the different metabolic variations in the evolution of DM through molecular markers [9] , however, there is still a need for a panel of markers that allows monitoring the earlier changes of this disease effectively. Among the molecular biomarkers which could re ect the early onset of DM are monocarboxylate transporters (Mcts) -representing cellular metabolism; cell surface receptor Cd147 -glycoprotein complementary to monocarboxylates; hypoxiainducible factor type one alpha unit (Hif-1α) -in oxygen homeostasis and vascular endothelial growth factor (Vegf) -in vascular cell proliferation were evaluated in this research.…”

Section: Introductionmentioning

confidence: 99%

Cellular metabolism genes expression in the onset of diabetic nephropathy: an experimental model of diabetes mellitus.

Encinas

Fonseca

Raimundo

et al. 2023

Preprint

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Diabetes mellitus is a chronic disease with prospects for an increase worldwide, therefore, researches are developed to understand its metabolic implications, as well as the early signaling of the onset of the disease and possible complications. The objective of this study was to evaluate the expression profile in the genes Mct1, Mct4, Cd147, Hif-1α and Vegffor different biological matrices in rats induced to diabetes in the determined periods of: 7, 21, 30 and 40 days. Wistar rats (160-180g, n=68), divided into shamand diabetic groups evaluated according to tissue samples from the heart, brain and kidney, blood samples; being studied in classical biochemical analysis and in the determination of intergroup differential gene expression, temporally, by qPCR. The main alterations were observed in the renal tissues - decrease in the expression of Hif-1α (21x30 days) and Vegf (21x40 days), and in the brain - with significant alterations in the evaluated genes, comparing the early group (7 days) and late groups (30 and 40 days). Thus, we observed that the evaluated genes are related to metabolic changes that, over time, corroborate the worsening of diabetes and the installation of secondary diseases, directly and/or indirectly related to the evaluated tissues.

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Kidney Diseases: The Age of Molecular Markers

Cited by 3 publications

References 117 publications

Introductory Chapter: An Overview of Nephritis, Nephrotic Syndrome, and Nephrosis

Introductory Chapter: An Overview of Nephritis, Nephrotic Syndrome, and Nephrosis

Acute kidney injury in patients with myocardial infarction and percutaneous coronary interventions: laboratory markers and the influence on the frequency of recurrent cardiovascular events

Cellular metabolism genes expression in the onset of diabetic nephropathy: an experimental model of diabetes mellitus.

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