Kidney Dysfunction Evaluation in Chronic Heart Failure Patients

Abstract

Aim. To study the signs of kidney dysfunction in chronic heart failure (CHF).Material and methods. We included 96 patients with postinfarction cardiosclerosis and CHF with the age of 40–60 years. Patients were divided into two groups by functional class (FC) of CHF according to NYHA. In all patients the levels of serum creatinine and MDRD glomerular filtration rate (GFR), urine alanine transferase, aspartat transferase, alkaline phosphatase and cholinaestherase by spectrophotometric method were measured.Results. In 33,3% of patients with II FC NYHA and in 66,67% with III FC NYHA we found GFR less than 60 ml/min/1,73 sq.m. Investigation of fermenturia levels in those according to renal functioning showed more prevalent increase of urine enzymes in lower GFR, in whom the patients with III FC NYHA consisted 66,67%. The level of ALT was 39% (p<0,01) higher and AP 35% (p<0,001) higher comparing to subjects without renal dysfunction.Conclusion. In patients with chronic heart failure as the diseases progresses there is kidney dysfunction developing with the decrease of GFR, increase of resdual nitrogen and enzimes in urine. Enzyme levels testing in urine of CHF patients can be a part of diagnostic approach to kidney dysfunction diagnostic at earlier stages.

Disorders of Kidney Function in Chronic Heart Failure

“…in patients with CHF is a natural manifestation of a functionally interrelated process at the organ level 8 . Moreover, impaired renal function is a common and independent factor in the progression of the disease, a high incidence of cardiovascular events and death in a population of patients with asymptomatic and / or clinically manifested CHF 9 , which is due to the pathogenetic features of the formation of CRS in patients with CHF of ischemic origin.…”

Features Of The Occurrence Of Helicobacter Pylori Infection With Gastroduodenal Pathology In Children

“…In 2007, according to T.V. Mishkina et al, a low prevalence of H. pylori genotypes cagA (7.91%) and vacAs1 (7.3%) was identified among children; the s2 allele of the vacuolating cytotoxin gene was found in 10.17% of children [12,13].…”