Kidney Flow and Function in Hypertension: Protective Effects of Pycnogenol in Hypertensive Participants—A Controlled Study

Cesarone, M. R.; Belcaro, Gianni; Stuard, Stefano; Schönlau, Frank; Renzo, A. Di; Grossi, Maria Giovanna; Dugall, Mark; Cornelli, Umberto; Cacchio, Marisa; Gizzi, G.; Pellegrini, L

doi:10.1177/1074248409356063

Cited by 26 publications

(43 citation statements)

References 25 publications

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“…The improvement of endothelial function with Pycnogenol was shown to decrease blood pressure in individuals with essential hypertension (Hosseini et al ., ; Zibadi et al ., ). These effects have been attributed to vaso‐dilatation which is associated with an improved level of perfusion as previously shown in peripheral circulation, the retina and the kidneys (Cesarone et al ., ; Steigerwalt et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Pycnogenol® Supplementation Improves Health Risk Factors in Subjects with Metabolic Syndrome

Belcaro¹,

Cornelli²,

Luzzi³

et al. 2013

Phytotherapy Research

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This open, controlled study evaluated the effects of 6 month supplementation with Pycnogenol® maritime pine bark extract on health risk factors in subjects with metabolic syndrome. Pycnogenol® was used with the aim of improving risk factors associated with metabolic syndrome, central obesity, elevated triglycerides (TG), low HDL cholesterol, high blood pressure and fasting blood glucose. Sixty-four subjects (range 45-55 years) presenting with all five risk factors of metabolic syndrome were included, and Pycnogenol® was administered for 6 months. A group of 66 equivalent subjects were followed up as controls. In the 6-month study Pycnogenol® supplementation 150 mg/day decreased waist circumference, TG levels, blood pressure and increased the HDL cholesterol levels in subjects. Pycnogenol lowered fasting glucose from baseline 123 ± 8.6 mg/dl to 106.4 ± 5.3 after 3 months and to 105.3 ± 2.5 at the end of the study (p < 0.05 vs controls). Men's waist circumference decreased with Pycnogenol from 106.2 ± 2.2 cm to 98.8 ± 2.3 cm and to 98.3 ± 2.1 after 3 and 6 months. Women's waist decreased from 90.9 ± 1.6 cm to 84.6 ± 2.1 cm and to 83.6 ± 2.2 cm after 3 and 6 months. Both genders waist circumference reduction was significant as compared to controls at both time points. In addition, plasma free radicals decrease in the Pycnogenol group was more effective than in the control group (-34.6%; p < 0.05). In conclusion, this study indicates a role for Pycnogenol® for improving health risk factors in subjects with metabolic syndrome.

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Section: Discussionmentioning

confidence: 97%

Pycnogenol® Supplementation Improves Health Risk Factors in Subjects with Metabolic Syndrome

Belcaro¹,

Cornelli²,

Luzzi³

et al. 2013

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…The improvement of endothelial function with Pycnogenol was shown to decrease blood pressure in individuals with essential hypertension (Hosseini et al, 2001, Zibadi et al, 2008. These effects have been attributed to vasodilatation, which is associated with an improved level of perfusion as previously shown in peripheral circulation, the retina, and the kidneys (Cesarone et al, 2008a, Steigerwalt et al, 2009. In individuals with metabolic syndrome, elevated blood pressure and blood glucose are the main factors related to the development of renal dysfunction presenting as micro-albuminuria (Atkins et al, 2003).…”

Section: Introductionmentioning

confidence: 82%

“…White blood cell and red blood cells counts and clotting factor remained within the normal range. Subjects were interviewed for adverse effect, but none was reported by any of the subject (Cesarone et al , , ).…”

Section: Clinical Researchmentioning

confidence: 99%

“…In both groups, CRP levels decreased from 2.1 to 1.8 with ramipril and from 2.2 to 1.1 with the ramipril–Pycnogenol combination; the latter reached statistical significance. On safety aspects, parameters relating to liver function (ALAT, ASAT, γ glutamyl transferase, alkaline phosphatase) and haematology (red blood cell, white blood cell and platelets) remained unchanged (Cesarone et al , ). The study results are shown in Table .…”

Section: Clinical Researchmentioning

confidence: 99%

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Pycnogenol® in Metabolic Syndrome and Related Disorders

Gulati

2015

Phytotherapy Research

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The present review provides an update of the biological actions of Pycnogenol® in the treatment of metabolic syndrome and related disorders such as obesity, dyslipidaemia, diabetes and hypertension. Pycnogenol® is a French maritime pine bark extract produced from the outer bark of Pinus pinaster Ait. Subsp. atlantica. Its strong antioxidant, antiinflammatory, endothelium-dependent vasodilator activity, and also its anti-thrombotic effects make it appropriate for targeting the multifaceted pathophysiology of metabolic syndrome. Clinical studies have shown that it can reduce blood glucose levels in people with diabetes, blood pressure in mild to moderate hypertensive patients, and waist circumference, and improve lipid profile, renal and endothelial functions in metabolic syndrome. This review highlights the pathophysiology of metabolic syndrome and related clinical research findings on the safety and efficacy of Pycnogenol®. The results of clinical research studies performed with Pycnogenol® are discussed using an evidence-based, target-oriented approach following the pathophysiology of individual components as well as in metabolic syndrome overall.

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“…Diastolic BP fell from 93.8 mmHg to 92.0 mmHg. Pycnogenol acts as a natural ACEI, protects cell membranes from oxidative stress, increases NO and improves endothelial function, reduces serum thromboxane concentrations, decreases myelo-peroxidase activity, improves renal cortical blood flow, reduces urinary albumin excretion and decreases HS-CRP [243][244][245][246][247] . Other studies have shown reductions in BP and a decreased need for ACEI and CCB, reductions in endothelin-1, HgA1C, fasting glucose, LDL-C and myeloperoxidase [244,245,247] .…”

Section: Pycnogenolmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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Kidney Flow and Function in Hypertension: Protective Effects of Pycnogenol in Hypertensive Participants—A Controlled Study

Cited by 26 publications

References 25 publications

Pycnogenol® Supplementation Improves Health Risk Factors in Subjects with Metabolic Syndrome

Pycnogenol® Supplementation Improves Health Risk Factors in Subjects with Metabolic Syndrome

Pycnogenol® in Metabolic Syndrome and Related Disorders

The role of nutrition and nutraceutical supplements in the treatment of hypertension

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