Kidney Function and Net Glucose Production in Normal and Acidotic Sheep

McIntosh, Graeme H.; Filsell, O H; Jarrett, I. G.

doi:10.1071/bi9731389

Cited by 6 publications

(2 citation statements)

References 4 publications

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“…For the SoL ewes slaughtered in a moribund state, the comparison suggests either that these hepatocytes were not able to express the gluconeogenic capacity of the liver in vivo or that there was some other source of glucose production. A large glucose production by the kidneys appear& unlikely, as the renal production of glucose has never been shown to be more than a small fraction of the glucose turnover rate (Kaufman and Bergman 1974;McIntosh et al 1973). Alternatively, the isolated cells may have been unable to take up substrates or they may have lacked essential cofactors and a suitable energy source.…”

Section: Discussionmentioning

confidence: 99%

Glucose Turnover and Hepatocyte Glucose Production of Starved and Toxaemic Pregnant Sheep

Wastney¹,

Wolff²,

Bickerstaffe³

1983

Aust. Jnl. Of Bio. Sci.

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Ewes bearing twins were starved for 10 days during the last month of gestation to induce ovine pregnancy toxaemia (OPT). Glucose turnover was measl,lred by a primed continuous infusion of [U_ '4C]_ and [6-3 HJglucose at the end of 10 days of starvation (non-susceptible), or earlier when ewes became recumbent with OPT (susceptible). All ewes were slaughtered at the end of the infusion and hepatocytes were prepared in order to measure glucose production from different substrates. Many of the ewes had dead foetuses when slaughtered. Glucose production rates by hepatocytes with the substrates propionate, lactate or alanine were significantly less from the susceptible ewes than were those from non-susceptible ewes. These low rates were not stimulated by incubation with glucagon (10-8 M), glutamine or glycerol. Rates of glucose turnover and of hepatic glucose production from all substrates were higher for ewes with dead than with live foetuses. The data support the hypothesis that pathogenesis of OPT is related to an impairment of hepatic gluconeogenesis, and further suggest that, in starved pregnant ewes, maternal glucose production may be restrained in the presence of a live foetus.

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Section: Discussionmentioning

confidence: 99%

Glucose Turnover and Hepatocyte Glucose Production of Starved and Toxaemic Pregnant Sheep

Wastney¹,

Wolff²,

Bickerstaffe³

1983

Aust. Jnl. Of Bio. Sci.

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“…Only small quantities of blood glucose are produced by the kidney (McIntosh et at. 1973) or absorbed from the alimentary tract of sheep given roughage (MacRae and Armstrong 1966).…”

Section: Discussionmentioning

confidence: 99%

Glucose and Acetate Metabolism in Sheep at Rest and During Exercise

Judson¹,

Filsell²,

Jarrett³

1976

Aust. Jnl. Of Bio. Sci.

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Total entry rate of blood glucose and the rate of irreversible loss of blood acetate and its oxidation have been examined in sheep at rest and while walking on a horizontal treadmill at 5 km/h for 2 h. Sheep were given their daily ration of 1000 g chaff in 24 eaual portions at hourly intervals and received multiple intravenous injections of [2-3H]glucose and intravenous infusions of [1-14C]acetate and NaH14CO3. At rest the total entry rate of blood glucose was 0-44 +/- 0-03 mmol/min (values given as mean +/- s.e.m. for four sheep), the glucose pool was 23 +/- 1 mmol and the rate of irreversible loss of blood acetate was 2-3 +/- 0-1 mmol/min. During exercise, the total entry rate of blood glucose was 0-84 +/- 0-04 mmol/min, the glucose pool was 27 +/- 2 mmol and the rate of irreversible loss of blood acetate was 2-6 +/- 0-1 mmol/min. Gluconeogenesis apparently increased markedly in response to exercise as indicated by the incorporation of 14C from blood bicarbonate into blood glucose. Despite the substantial increase in the rate of irreversible loss of blood bicarbonate (from 11-6 +/- 1 to 20-2 +/- 2 mmol C/min), and hence energy expenditure with exercise, only a slight change was recorded in the proportion of the irreversible loss rate of acetate that was oxidized.

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Effects of an intravenous infusion of hydrochloric acid on renal function in sheep

Williams

Pickering

1980

Research in Veterinary Science

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Kidney Function and Net Glucose Production in Normal and Acidotic Sheep

Cited by 6 publications

References 4 publications

Glucose Turnover and Hepatocyte Glucose Production of Starved and Toxaemic Pregnant Sheep

Glucose Turnover and Hepatocyte Glucose Production of Starved and Toxaemic Pregnant Sheep

Glucose and Acetate Metabolism in Sheep at Rest and During Exercise

Effects of an intravenous infusion of hydrochloric acid on renal function in sheep

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