Kidney function and other associated factors of sarcopenia in community-dwelling older adults: The SCOPE study

Moreno-González, Rafael; Cruzado, Josep Maria; Corsonello, Andrea; Fabbietti, Paolo; Tap, Lisanne; Mattace-Raso, Francesco; Ärnlöv, Johan; Carlsson, Axel C.; Guligowska, Agnieszka; Kostka, Tomasz; Artzi-Medvedik, Rada; Melzer, Itshak; Roller-Wirnsberger, Regina; Wirnsberger, Gerhard; Kob, Robert; Sieber, Cornel; Lattanzio, Fabrizia; Formiga, Francesc

doi:10.1016/j.ejim.2023.12.002

Cited by 9 publications

(4 citation statements)

References 48 publications

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“…Furthermore, Foley et al ( 221 ) showed that prevalence of sarcopenia in US older adults increases from 26.6% when estimated glomerular filtration rate (eGFR) is ≥90 mL/min/1.73 m 2 , to 38.9% when eGFR is 60–89 to more than 60% for eGFR <60 mL/min. Such findings have been recently confirmed by Formiga et al ( 222 ) in a large cohort of community-dwelling older adults from 7 European countries; along with evidence of a graded increase in prevalence of sarcopenia from CKD stages 1–2 to more advanced 3–4, authors showed that the interplay between eGFR and muscle loss was independent from equations used to estimate GFR ( 95 , 222 ). Another cross-sectional study conducted in 95 dialysis patients revealed that sarcopenia is highly prevalent in older patients with ESKD, with a prevalence of 37.0% in men and 29.3% in women patients.…”

Section: Interplay Between Functional Impairment and Ckdmentioning

confidence: 57%

“…On the other hand, a recent meta-analysis comprising six studies has shown that eGFR based on BTP and B2M improves the detection of patients at risk of ESKD compared to the traditional eGFR equations ( 67 ). Furthermore, a recent cross-sectional analysis showed that estimation of eGFR by use of CKD-EPI BTP-B2M was independently associated with sarcopenia in community-dwelling older individuals in contrast to creatinine and cystatin C-based equations ( 95 ).…”

Section: Biomarkers Of Kidney Functionmentioning

confidence: 99%

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Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis

Muglia,

Di Dio,

Filicetti

et al. 2024

Front. Med.

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Chronic kidney disease (CKD) in older individuals is a matter of growing concern in the field of public health across the globe. Indeed, prevalence of kidney function impairment increases with advancing age and is often exacerbated by age-induced modifications of kidney function, presence of chronic diseases such as diabetes, hypertension, and cardiovascular disorders, and increased burden related to frailty, cognitive impairment and sarcopenia. Accurate assessment of CKD in older individuals is crucial for timely intervention and management and relies heavily on biomarkers for disease diagnosis and monitoring. However, the interpretation of these biomarkers in older patients may be complex due to interplays between CKD, aging, chronic diseases and geriatric syndromes. Biomarkers such as serum creatinine, estimated glomerular filtration rate (eGFR), and albuminuria can be significantly altered by systemic inflammation, metabolic changes, and medication use commonly seen in this population. To overcome the limitations of traditional biomarkers, several innovative proteins have been investigated as potential, in this review we aimed at consolidating the existing data concerning the geriatric aspects of CKD, describing the challenges and considerations in using traditional and innovative biomarkers to assess CKD in older patients, highlighting the need for integration of the clinical context to improve biomarkers’ accuracy.

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Section: Interplay Between Functional Impairment and Ckdmentioning

confidence: 57%

Section: Biomarkers Of Kidney Functionmentioning

confidence: 99%

Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis

Muglia,

Di Dio,

Filicetti

et al. 2024

Front. Med.

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“…However, concerns may exist regarding the use of creatinine-based equations as they may misestimate GFR in conditions in which creatinine formation is decreased, as in sarcopenic older adults. Because muscle mass is a major determinant in the generation of creatinine, measured GFR via inulin or iohexol clearance methods could be more appropriate in these patients [36]. Thus, it is possible that the subjects of this study also had overestimated GFR during their routine examinations and were not aware of CKD [37].…”

Section: Other Explanationsmentioning

confidence: 99%

Sarcopenia, a Risk Predictor of Postoperative Acute Kidney Injury in Elderly Patients after Hip Fracture Surgery: A Retrospective Analysis

Koh,

Jun,

Kim

et al. 2024

Medicina

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Background and Objectives: Hip fracture surgery, which affects quality of life, can be a major challenge in geriatric populations. Although sarcopenia is known to be associated with postoperative outcomes, there are few studies on the association between sarcopenia and postoperative acute kidney injury (AKI) in this population. We investigated the association between sarcopenia and postoperative AKI in elderly patients following hip fracture surgery. Materials and Methods: We retrospectively reviewed the records of patients who underwent hip fracture surgery at our institution from March 2019 to December 2021. Patients under the age of 65, patients with no preoperative computed tomography (CT) scans and patients with inappropriate cross-sectional images for measurement were excluded. The psoas-lumbar vertebral index (PLVI), which is the ratio of the average area of both psoas muscles to the area of the fourth lumbar vertebral body, was measured from preoperative CT scans. Sarcopenia was defined as a PLVI within the lowest 25% for each sex, and patients were categorized into sarcopenic and nonsarcopenic groups. The occurrence of AKI was determined based on the serum creatinine level within postoperative day 7 using the Kidney Disease Improving Global Outcomes (KDIGO) guidelines. Univariate and multivariate logistic regression analyses were performed to evaluate the associations between clinical variables and the occurrence of AKI. Results: Among the 348 enrolled patients, 92 patients were excluded, and 256 patients were analyzed. The PLVI cutoff values for defining sarcopenia lower than 25% for male and female patients were 0.57 and 0.43, respectively. The overall incidence of AKI was 18.4% (47 patients), and AKI occurred more frequently in sarcopenic patients than in nonsarcopenic patients (29.7% vs. 14.6%, p = 0.007). According to the multivariate logistic regression, which included all variables with a p value < 0.05 in the univariate analysis and adjusted for age, body mass index (BMI) and American Society of Anesthesiologists (ASA) physical status, sarcopenia was revealed to be an independent predictor of postoperative AKI (odds ratio = 5.10, 95% confidence interval = 1.77–14.77; p = 0.003). Conclusions: Preoperative sarcopenia, which corresponds to the lowest quartile of PLVI values, is associated with postoperative AKI among elderly patients who underwent hip fracture surgery.

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“…In terms of etiology, sarcopenia is recognized as a multifactorial condition. The aging process contributes to its development through diverse mechanisms, while systemic diseases as diabetes ( 19 , 20 ), malignities, and organic insufficiencies may also be involved as chronic kidney disease ( 2 , 19 , 20 ). Recent reports suggest that alterations of people’s nutritional status due to low caloric and protein ingestion –especially malnutrition and the risk of malnutrition (RM)– are associated independently with a greater risk of developing sarcopenia in older adults ( 2 , 17 , 21–23 ).…”

Section: Introductionmentioning

confidence: 99%

Association between the risk of malnutrition and sarcopenia at 4.2 years of follow-up in community-dwelling older adults

Vidaña-Espinoza,

López-Teros,

Esparza-Romero

et al. 2024

Front. Med.

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IntroductionCurrently, there is only scarce evidence of a causal association between risk of malnutrition (RM) by the mini-nutritional assessment (MNA) and the incidence of sarcopenia. This study was designed to assess such an association at 4.2 years of follow-up in community-dwelling subjects over 60 years old.MethodsThe data used were from the FraDySMex cohort study. The exposition variables were RM diagnosed by the long forma of the MNA (MNA-LF) and short form (MNA-SF). The last one included the body mass index and calf circumference at baseline, while sarcopenia was diagnosed by the EWGSOP2 at follow-up and taken as the response variable. Several covariates involved in the association were also considered. A multiple logistic regression analysis was performed to test the association.ResultsAt baseline, 27.0 and 37.9% of subjects had RM by the MNA-LF and MNA-SF, respectively. The incidence of sarcopenia was 13.7%. The fat mass variable significantly modified the association, so it was tested in each stratum. Two independent models showed that subjects with RM by the MNA-LF in the normal fat mass stratum were at a higher risk for developing sarcopenia at follow-up than those without RM (OR 9.28; IC 95% 1.57–54.76) after adjusting for age, sex, and waist circumference. No association was found for the excess fat mass stratum subjects. Subjects with RM by the MNA-SF in the excess fat mass stratum were more likely to develop sarcopenia at follow-up than those without RM by the MNA-SF (OR 3.67; IC 95% 1.29–10.43). This association was not found in the subjects in the normal fat mass stratum.ConclusionThe association was dependent on the variable fat mass. The two forms of the MNA should not be applied indistinctly with older adults. Based on these results, it is clear that the risk of malnutrition precedes the onset of sarcopenia.

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Kidney function and other associated factors of sarcopenia in community-dwelling older adults: The SCOPE study

Cited by 9 publications

References 48 publications

Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis

Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis

Sarcopenia, a Risk Predictor of Postoperative Acute Kidney Injury in Elderly Patients after Hip Fracture Surgery: A Retrospective Analysis

Association between the risk of malnutrition and sarcopenia at 4.2 years of follow-up in community-dwelling older adults

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