Kidney function and renal resistive index in children with juvenile idiopathic arthritis

Cafarotti, Alessandro; Marcovecchio, M Loredana; Lapergola, Giuseppe; Battista, Caterina Di; Marsili, Manuela; Basilico, Raffaella; Donato, Giulia Di; David, Daniela; Pelliccia, Piernicola; Chiarelli, Francesco; Breda, Luciana

doi:10.1007/s10238-022-00898-x

Cited by 5 publications

(10 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

“…Juvenile idiopathic arthritis is one of the most frequent rheumatic diseases in children [131]. Amyloidosis is the most common renal lesion in juvenile idiopathic arthritis, but membranous glomerulopathy, mesangial nephropathy, focal glomerulosclerosis and antineutrophil cytoplasmatic antibody-negative glomerulonephritis are also described [131,132]. Albuminuria is the gold standard for the diagnosis of renal injury, but RRI is a more sensitive parameter that can early identify renal dysfunction in rheumatic arthritis [131].…”

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

“…Amyloidosis is the most common renal lesion in juvenile idiopathic arthritis, but membranous glomerulopathy, mesangial nephropathy, focal glomerulosclerosis and antineutrophil cytoplasmatic antibody-negative glomerulonephritis are also described [131,132]. Albuminuria is the gold standard for the diagnosis of renal injury, but RRI is a more sensitive parameter that can early identify renal dysfunction in rheumatic arthritis [131]. In addition, RRI has a linear correlation with C-reactive protein and JADAS (Juvenile Arthritis Disease Activity Score) scale, suggesting an additional inflammatory mechanism of renal injury, associated to endothelial dysfunction and subclinical atherosclerosis [131,132].…”

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

“…Albuminuria is the gold standard for the diagnosis of renal injury, but RRI is a more sensitive parameter that can early identify renal dysfunction in rheumatic arthritis [131]. In addition, RRI has a linear correlation with C-reactive protein and JADAS (Juvenile Arthritis Disease Activity Score) scale, suggesting an additional inflammatory mechanism of renal injury, associated to endothelial dysfunction and subclinical atherosclerosis [131,132].…”

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

See 3 more Smart Citations

Current Insights into Renal Resistive Index Significance in Kidney and Cardiovascular Disease

Darabont¹,

Mihalcea²,

Vinereanu³

2023

Preprint

View full text Add to dashboard Cite

Initially, renal resistive index (RRI) was investigated to improve diagnosis in kidney diseases, but failed to meet this goal. Recently many papers highlighted the prognostic significance of RRI in chronic kidney disease, in the estimation of revascularization success of renal artery stenoses or the evolution of the graft and recipients in renal transplantation. Moreover, RRI gained importance in prediction of acute kidney injury in critically ill patients. Along with RRI study in renal pathology have been revealed correlations of this index with parameters of systemic circulation. The theoretical and experimental premises of this connection were reconsidered, and studies for analyzing the link between RRI and arterial stiffness, central and peripheral pressure or left ventricular flow were conducted with this purpose. A high amount of data is currently indicating that RRI is influenced more by pulse pressure and vascular compliance than by renal vascular resistance – assuming that RRI reflects the complex interplay between systemic circulation and renal microcirculation and should be considered as a marker of systemic cardiovascular risk beyond its prognostic relevance for kidney disease. In this review we will go through clinical research that revealed the implications of RRI in renal and cardiovascular disease.

show abstract

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

Section: Rri Interaction With Other Diseasesmentioning

confidence: 99%

See 2 more Smart Citations

Current Insights into Renal Resistive Index Significance in Kidney and Cardiovascular Disease

Darabont¹,

Mihalcea²,

Vinereanu³

2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Despite the known correlation between chronic inflammation and risk of early endothelial dysfunction and renal damage described in adults with RA (rheumatoid arthritis) ( 10 ), there are only few published data assessing the renal involvement risk in children with JIA ( 11 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Proteinuria and hematuria as early signs of renal involvement in juvenile idiopathic arthritis

Del Giudice,

Marcellino,

Hoxha

et al. 2024

Front. Pediatr.

View full text Add to dashboard Cite

ObjectivesTo evaluate glomerular and tubular renal functions and analyze blood pressure in a cohort of pediatric patients with juvenile idiopathic arthritis (JIA).MethodsA total of 40 pediatric patients, 20 (50%) with JIA and 20 (50%) healthy control subjects, were studied, and performed the renal function on 24-h collection and the 24-h ambulatory blood pressure monitoring (ABPM). Moreover, we compared renal function and blood pressure trends between the groups of JIA patients with different disease activities.ResultsNo statistically significant differences were observed between patients with JIA and healthy children in terms of glomerular filtration rate (GFR), fractional excretion of sodium (FENa), tubular reabsorption of phosphate (TRP), and calcium-creatinine urine ratio (CaU/CrU). In contrast, we observed significantly higher values in JIA patients than in controls for the presence of hematuria (p < 0.0001) and proteinuria (p < 0.0001). Compared to the control group there were significantly higher values of hematuria and proteinuria/day in both groups of JIA patients with low disease activity (respectively, p = 0.0001 and p = 0.0002) and moderate disease activity (respectively p = 0.0001 and p = 0.0012). Systolic and diastolic dipping were significantly reduced in patients with JIA compared with healthy controls (p < 0.0001 and p < 0.0001, respectively).ConclusionsOur study showed that children with JIA, already in the early stages of the disease, have higher values of hematuria and proteinuria, which are early warning signs of nephropathy. Therefore, detailed screening of renal function and pressure monitoring in patients are necessary to monitor their evolution over time.

show abstract

Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease

2023

View full text Add to dashboard Cite

Initially, the renal resistive index (RRI) was investigated with the aim of improving diagnosis in kidney diseases, but this goal was not met. Recently, many papers have highlighted the prognostic significance of the RRI in chronic kidney disease: specifically, in estimating the revascularization success of renal artery stenoses or the evolution of the graft and the recipients in renal transplantation. Moreover, the RRI has become significant in the prediction of acute kidney injury in critically ill patients. Studies in renal pathology have revealed correlations of this index with parameters of systemic circulation. The theoretical and experimental premises of this connection were then reconsidered, and studies analyzing the link between RRI and arterial stiffness, central and peripheral pressure, and left ventricular flow were conducted with this purpose. Many data currently indicate that RRI is influenced more by pulse pressure and vascular compliance than by renal vascular resistance—assuming that RRI reflects the complex interplay between systemic circulation and renal microcirculation and should be considered a marker of systemic cardiovascular risk beyond its prognostic relevance for kidney disease. In this review, we overview the clinical research that reveals the implications of RRI in renal and cardiovascular disease.

show abstract

Kidney function and renal resistive index in children with juvenile idiopathic arthritis

Cited by 5 publications

References 27 publications

Current Insights into Renal Resistive Index Significance in Kidney and Cardiovascular Disease

Current Insights into Renal Resistive Index Significance in Kidney and Cardiovascular Disease

Proteinuria and hematuria as early signs of renal involvement in juvenile idiopathic arthritis

Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease

Contact Info

Product

Resources

About