Kidney function assessment using cystatin C and serum creatinine in heart transplantation recipients: Implications for valganciclovir dosing

Pinsino, Alberto; Jennings, Douglas L.; Ladanyi, Annamaria; Duong, Phuong; Sweat, Austin O.; Mahoney, Ian; Bohn, Bruno; Demmer, Ryan T.; Takeda, Koji; Sayer, Gabriel T.; Uriel, Nir; Leb, Jay S.; Husain, Syed A.; Mohan, Sumit; Colombo, Paolo C.; Yuzefpolskaya, Melana

doi:10.1016/j.healun.2024.07.015

The Journal of Heart and Lung Transplantation

2024

DOI: 10.1016/j.healun.2024.07.015

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Kidney function assessment using cystatin C and serum creatinine in heart transplantation recipients: Implications for valganciclovir dosing

Alberto Pinsino,

Douglas L. Jennings,

Annamaria Ladanyi

et al.

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Pre‐operative pectoralis muscle area index is associated with biomarkers of inflammation and endotoxemia and predicts clinical outcomes after left ventricular assist device implantation: A cohort study

Carey,

Ladanyi,

Nishikawa

et al. 2024

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BackgroundPre‐left ventricular assist device (LVAD) pectoralis muscle assessment, an estimate of sarcopenia, has been associated with postoperative mortality and gastrointestinal bleeding, though its association with inflammation, endotoxemia, length‐of‐stay (LOS), and readmissions remains underexplored.MethodsThis was a single‐center cohort study of LVAD patients implanted 1/2015–10/2018. Preoperative pectoralis muscle area was measured on chest computed tomography (CT), adjusted for height squared to derive pectoralis muscle area index (PMI). Those with PMI in the lowest quintile were defined as low‐PMI cohort; all others constituted the reference cohort. Biomarkers of inflammation (interleukin‐6, adiponectin, tumor necrosis factor‐α [TNFα]) and endotoxemia (soluble (s)CD14) were measured in a subset of patients.ResultsOf the 254 LVAD patients, 95 had a preoperative chest CT (median days pre‐LVAD: 7 [IQR 3–13]), of whom 19 (20.0%) were in the low‐PMI cohort and the remainder were in the reference cohort. Compared with the reference cohort, the low‐PMI cohort had higher levels of sCD14 (2594 vs. 1850 ng/mL; p = 0.04) and TNFα (2.9 vs. 1.9 pg/mL; p = 0.03). In adjusted analyses, the low‐PMI cohort had longer LOS (incidence rate ratio 1.56 [95% confidence interval 1.16–2.10], p = 0.004) and higher risk of 90‐day and 1‐year readmissions (subhazard ratio 5.48 [1.88–16.0], p = 0.002; hazard ratio 1.73 [1.02–2.94]; p = 0.04, respectively).ConclusionsPre‐LVAD PMI is associated with inflammation, endotoxemia, and increased LOS and readmissions.

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Pre‐operative pectoralis muscle area index is associated with biomarkers of inflammation and endotoxemia and predicts clinical outcomes after left ventricular assist device implantation: A cohort study

Carey,

Ladanyi,

Nishikawa

et al. 2024

Artificial Organs

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show abstract

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Kidney function assessment using cystatin C and serum creatinine in heart transplantation recipients: Implications for valganciclovir dosing

Cited by 1 publication

References 35 publications

Pre‐operative pectoralis muscle area index is associated with biomarkers of inflammation and endotoxemia and predicts clinical outcomes after left ventricular assist device implantation: A cohort study

Pre‐operative pectoralis muscle area index is associated with biomarkers of inflammation and endotoxemia and predicts clinical outcomes after left ventricular assist device implantation: A cohort study

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