Kidney function, urinalysis abnormalities and correlates in equatorial Africans with sickle cell disease

Kaze, François Folefack; Kengne, André Pascal; Atanga, Léonel Christophe; Lobe, M. Monny; Menanga, Alain; Halle, Marie-Patrice; Chemegni, Bernard Chetcha; Sack, Françoise Ngo; Kingué, Samuel; Ashuntantang, Gloria

doi:10.1093/ckj/sfs100

Cited by 13 publications

(10 citation statements)

References 19 publications

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“…Laboratory data included serum and urinary creatinine, and urinary protein. The methods for urine and blood specimen analysis at the Yaoundé Central Hospital’s laboratory have been described in details elsewhere [ 20 ]. Secondary variables were derived from primary variables using validated formulas.…”

Section: Methodsmentioning

confidence: 99%

Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study

Kaze

Njukeng

Kengne

et al. 2014

BMC Pregnancy Childbirth

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BackgroundPreeclampsia and eclampsia, which are the most frequent hypertensive disorders in pregnancy, are associated with renal involvements. We aimed to assess the time trend in blood pressure levels, renal function and proteinuria after delivery, and investigate their determinants in Cameroonian women with severe preeclampsia and eclampsia.MethodsThis was a prospective cohort study involving 54 women with severe preeclampsia and eclampsia, conducted between July 2010 and February 2012 at the central maternity unit of the Yaoundé Central Hospital. Clinical and laboratory parameters were recorded from day-1 to 6 months after delivery. Mixed-linear and logistic regression models were used to relate baseline and within follow-up levels of covariates, with changes in blood pressure levels, renal function and proteinuria, as well as persisting hypertension, renal failure and proteinuria.ResultsDuring follow-up, a significant improvement was observed in blood pressure, renal function and proteinuria (all p < 0.002). Thirteen (24.1%) patients with renal failure at delivery recovered completely within six weeks. Twenty-six (48.1%), 17 (31.5%) and 1 (1.8%) patients had persisting proteinuria at 6 weeks, 3 months and 6 months post-delivery, respectively. Corresponding figures for persisting hypertension were 23 (42.6%), 15 (27.8%) and 8 (14.8%). Advanced age, higher body mass index, low gestational age at delivery, low fetal birth weight, and proteinuria at delivery were the main risk factors for persisting hypertension at 3 months, meanwhile low fetal birth weight, severe preeclampsia and proteinuria at delivery were correlated with persisting proteinuria at 3 months. Advanced age and higher body mass index were the only determinants of the composite outcome of persisting hypertension or proteinuria at three and six months.ConclusionHypertension and proteinuria are very common beyond the postpartum period in Cameroonian women with severe preeclampsia and eclampsia. Long-term follow-up of these women will help preventing and controlling related complications.

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Section: Methodsmentioning

confidence: 99%

Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study

Kaze

Njukeng

Kengne

et al. 2014

BMC Pregnancy Childbirth

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“…Moreover, recent studies underline SCT as a risk factor of chronic kidney disease in Africans Americans [10]. In a Cameroon, Kaze, et al reported high frequency of proteinuria (94%) compare to other African studies [11,12]; other kidney abnormalities were leucocyturia (78%), hematuria (14%) and low estimated glomerular filtration rate (1.5%). However, the exact prevalence of chronic kidney disease in SCA is not known since the persistence of these anomalies at 3 months was not evaluated.…”

Section: Introductionmentioning

confidence: 94%

Chronic Kidney Disease in Sickle Cell Disease: Prevalence and Associated Factors in Cameroon

Fouda¹,

Gilles²,

F³

et al. 2019

J Clin Nephrol Ren Care

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Background: Studies in Cameroon reported high prevalence of urinary abnormalities in sickle cell anemia (SCA). There is a lack of data in this setting on the prevalence of chronic kidney disease (CKD) in SCA and Sickle cell trait (SCT).Objective: Assess the prevalence and associate factors of CKD in people with sickle cell disease.Patients and method: This was a cross-sectional study of six months durations (April-September 2017) involving SCA (HB SS) and SCT (HBAS) subjects at Douala Laquintinie hospital. CKD was diagnosed and classified according to 2012 Kidney Disease Improving Global Outcomes (KDIGO) criteria. Only patients with persistent urinary anomalies or decreased eGFR at 3 months were considered to have CKD.Results: We included 107 subjects among which 81 SCA (62% males) and 26 SCT (46% males) with a mean age of 19.5 ± 10 and 35.8 ± 7.8 years (p < 0.001) respectively. Compare to SCT, SCA subjects had lower body mass index and systolic blood pressure. Overall, CKD was found in 16 patients (15%): 13 (16%) patients in the SCA group and 3 patients (11%) in the SCT group. CKD frequency was comparable in both groups (p = 0.76). CKD was found in 37% of adult SCA patients. Albuminuria was more common in the SCA group [12 (15%) vs. 1 (4%) patient, p = 0.018]. Age ≤ 25 years was protective factor for both CKD (OR = 0.20 [0.003-0.135], p < 0.001) and albuminuria (OR = 0.23 [0.004-0.124], p < 0.001) in SCD group. Conclusion:CKD in sickle cell disease is highly prevalent young adult in our setting.

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“…The maximum urinary concentration declines with age in SCA and SCT [39]. Subsequent studies, using urine specific gravity or urine osmolality, demonstrated hyposthenuria in SCA and SCT as well [40][41][42].…”

Section: Enuresis In Sca: the Postulated Etiologymentioning

confidence: 99%

Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

Ahmed¹

2017

Med Surg Urol

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Children with sickle cell anemia (SCA) have a tendency to have nocturnal enuresis (NE) more than normal children with males being more affected than females. Mechanisms of NE that operate in normal children probably do so in children with SCA. Postulated causes of nocturnal enuresis in individuals with SCA include hyposthenuria causing nocturnal polyuria, reduced bladder capacity or nocturnal bladder overactivity, sleep disordered breathing and an increased arousal thresholds. The variation in the reported prevalence rate of NE in SCA is probably due to differences in definition criteria and methodology. This review will discuss the prevalence rate and postulated causes of NE in children with SCA.

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Kidney function, urinalysis abnormalities and correlates in equatorial Africans with sickle cell disease

Cited by 13 publications

References 19 publications

Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study

Post-partum trend in blood pressure levels, renal function and proteinuria in women with severe preeclampsia and eclampsia in Sub-Saharan Africa: A 6-months cohort study

Chronic Kidney Disease in Sickle Cell Disease: Prevalence and Associated Factors in Cameroon

Nocturnal Enuresis in Children and Adolescent with Sickle cell Anemia

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