Kidney injury and oxidative damage alleviation by Zingiber officinale: pharmacokinetics and protective approach in a combined murine model of osteoporosis

Zammel, Nourhene; Jedli, Olfa; Rebaï, Tarek; Hamadou, Walid Sabri; Elkahoui, Salem; Jamal, Arshad; Alam, Md. Jahoor; Adnan, Mohd; Siddiqui, Arif Jamal; Alreshidi, Mousa; Naı̈li, Houcine; Badraoui, Riadh

doi:10.1007/s13205-022-03170-x

Cited by 20 publications

(24 citation statements)

References 101 publications

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“…In HBoV-positive patients, AST, LDH, URE, CK-MB, and Mg levels were significantly different from those in HBoV-negative patients. According to the results of previous studies, AST, URE, and CK-MB were the biochemical indexes of liver dysfunction (Pilut et al, 2022 ), kidney injury (Zammel et al, 2022 ), and heart injury (Pilut et al, 2022 ), respectively. Elevated LDH levels were also often found in patients with myocarditis (Kostik et al, 2022 ).…”

Section: Discussionmentioning

confidence: 95%

Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China

et al. 2022

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Persistent infection and prolonged shedding of human bocavirus 1 (HBoV1) in children have been reported, and the role of HBoV1 as a sole causative pathogen in acute respiratory infection (ARI) is yet to be established. While the reported prevalence of HBoV infection varies due to different detection methods and sampling criteria, determining the viral and bacterial etiology of HBoV infection using multiplex real-time PCR is yet to be reported. Herein, we aimed to further explore the pathogenicity of HBoV in patients with ARI by screening the viral and bacterial infections in children with ARI in Qingdao and comparing the epidemiological, clinical characteristics, and etiological results. Human bocavirus was identified in 28.1% of the samples, and further sequencing analysis of the detected HBoV confirmed 96.4% as HBoV1. The rate of HBoV as a single viral infection was 75%, and the rate of coinfection with bacteria was 66.1%, suggesting the need for continued monitoring of HBoV in children with ARIs. Clinical characterization suggested that HBoV infection may affect the function of organs, such as the liver, kidney, and heart, and the blood acid–base balance. Additionally, it is essential to promote awareness about the importance of disinfection and sterilization of the hospital environment and standardizing operations. The interactions between HBoV and other pathogens remain to be investigated in further detail in the future.

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Section: Discussionmentioning

confidence: 95%

Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China

et al. 2022

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“…The phytochemical profiling of the plant was associated with promising bioactivities such as antioxidant, anticancer, antibacterial and antiviral effects [ 7 , 8 ]. In this study, these compounds were assessed for their draggability and pharmacokinetics based on their ADMET characteristics, as previously described [ 5 , 22 , 33 ]. The assessment of such parameters was reported to be important to avoid drug failure in the advanced steps of clinical applications [ 23 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…2, possessed acceptable lipophilicity, as Log P o/w varied between 1.93 and 5.36. Previous reports indicated that Log P o/w < 5 is usually associated with good lipophilicity [ 5 , 21 , 22 , 33 ]. Their bioavailability scores prove their potential biological activities and the possibility of oral administration.…”

Section: Discussionmentioning

confidence: 99%

“…Among these, T. polium is a plant which belongs to the Labiatae family. Both the structural diversity of natural products and the better understanding of their nutraceutical/biological activities have led to increased interest in their applications in drug discovery and development [ 2 , 3 , 4 , 5 ]. Teucrium species are commonly used as alimentary plants, and some of them are currently used in herbal teas and infusions of leaves.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics and Therapeutic Potential of Teucrium polium, a Medicinal and Endangered Species in Ha'il Region, against Liver Damage Associated Hepatotoxicity and Oxidative Injury in Rats: Computational, Biochemical and Histological Studies

Rahmouni

Badraoui

Ben-Nasr

et al. 2022

Life

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This study investigated the druggability, pharmacokinetics and ethyl acetate extract of Teucrium polium (EA T. polium) and the protective effect against carbon tetrachloride (CCl4) induced liver cirrhosis in rats. The total antioxidant capacity (TAC) and scavenging activity of the extract were examined. The in vivo protective study was based on the use of an animal model of CCl4-induced liver cirrhosis. Four groups of rats have been used: Group I: control rats; Group II: received CCl4 in olive oil (0.5 mL/kg); Group III: received the EA T. polium (25 mg/kg) of pretreatment for seven days by gavage then CCl4 in olive oil by gavage for 15 days. Group IV: received the EA of T. polium for seven days (25 mg/kg). EA T. polium was found to possess significant antioxidant capacity. CCl4 caused a hepatotoxicity associated increase in both levels of AST and ALT, which were reduced back to normal values following EA T. polium pretreatment. Hepatotoxicity associated structural modifications of liver tissues and increase in thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and carbonyl proteins (CP), associated decreases in several assessed antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT). The in vivo findings on the protective effect of T. polium were supported by its druggability, its pharmacokinetic properties and molecular docking assays. These results confirm the modulatory antioxidant and hepatoprotective potential of T. polium in this experimental liver cirrhosis model. T. polium phytochemicals are good candidates for further pharmaceutical explorations and drug design.

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“… Boufahja et al, 2014 , Hedfi et al, 2022 , Jedli et al, 2022 , Mhadhbi et al, 2022 , Zammel et al, 2022 …”

Section: Uncited Referencesmentioning

confidence: 99%

How toxic is the COVID-19 drug azithromycin in the presence of Posidonia oceanica? Toxicokinetics and experimental approach of meiobenthic nematodes from a metallically pristine area

Badraoui

Mannai

Siddiqui

et al. 2023

Environmental Pollution

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Kidney injury and oxidative damage alleviation by Zingiber officinale: pharmacokinetics and protective approach in a combined murine model of osteoporosis

Cited by 20 publications

References 101 publications

Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China

Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China

Pharmacokinetics and Therapeutic Potential of Teucrium polium, a Medicinal and Endangered Species in Ha'il Region, against Liver Damage Associated Hepatotoxicity and Oxidative Injury in Rats: Computational, Biochemical and Histological Studies

How toxic is the COVID-19 drug azithromycin in the presence of Posidonia oceanica? Toxicokinetics and experimental approach of meiobenthic nematodes from a metallically pristine area

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