Kidney–liver pathophysiological crosstalk: its characteristics and importance

Capalbo, Olivia Maria; Giuliani, Sofía; Ferrero-Fernández, Alberta; Casciato, Paola; Musso, Carlos G.

doi:10.1007/s11255-019-02288-x

Cited by 50 publications

(15 citation statements)

References 24 publications

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“…Another basic function of the liver and kidney 28 is the ability to maintain a physiological acid-base balance. All of the livers in this series were able to sustain an intended perfusate pH of >7.2 without much need for bicarbonate.…”

Section: Discussionmentioning

confidence: 99%

Perfusate Enzymes and Platelets Indicate Early Allograft Dysfunction After Transplantation of Normothermically Preserved Livers

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Perfusate Enzymes and Platelets Indicate Early Allograft Dysfunction After Transplantation of Normothermically Preserved Livers

et al. 2022

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“…Distant organ liver damage after AKI remains a serious clinical setting with high mortality [ 21 ]. Knowing the characteristics of this kidney-liver crosstalk is crucial for handling the complications induced by this vicious circle [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although substantial improvement has been achieved, no effective preventive or therapeutic options exist for AKI. Recent studies show that AKI is linked to a wide range of distant organ injuries, with the liver, heart, lungs, and intestines representing the most clinically relevant affected organs [ 3 – 5 ]. In most cases, AKI may be due to the development of organ interactions in the disease state.…”

Section: Introductionmentioning

confidence: 99%

Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study

et al. 2021

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Background The relationship between fibrosis-4 (FIB-4) index and clinical outcomes in patients with acute kidney injury (AKI) is unclear. We aimed to investigate the association between FIB-4 index and all-cause mortality in critically ill patients with AKI. Methods We used data from the Multiparameter Intelligent Monitoring in Intensive Care III (MIMIC-III) database (v1.4). The FIB-4 score was calculated using the existing formulas. logistic regression model, and Cox proportional hazards model were used to assessed the relationship between the FIB-4 index and in-hospital,28-day and 90-day mortality, respectively. Results A total of 3592 patients with AKI included in the data analysis. 395 (10.99%) patients died during hospitalization and 458 (12.74%) patients died in 28-day. During the 90-day follow-up, 893 (22.54%) patients were dead. An elevated FIB-4 value was significantly associated with increased in-hospital mortality when used as a continuous variable (odds ratio [OR] 1.183, 95% confidence interval [CI] 1.072–1.305, P = 0.002) and as a quartile variable (OR of Q2 to Q4 1.216–1.744, with Q1 as reference). FIB-4 was positively associated with 28-day mortality of AKI patients with hazard ratio (HR) of 1.097 (95% CI 1.008, 1.194) and 1.098 (95% 1.032, 1.167) for 90-day mortality, respectively. Conclusion This study demonstrated the FIB-4 index is associated with clinical outcomes in critically ill patients with acute kidney injury.

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“…There is demonstrable liver injury after ischaemic renal injury, with derangement of AST/ALT and evidence of hepatocyte apoptosis ( via activation of NFB-receptor)[ 82 , 83 ]. IL-10, IL-6 and TNFα are upregulated within the liver and multiple markers of oxidative stress have been identified following ischaemic AKI.…”

Section: The Injured Kidney May Modulate the Progression Of Liver Ir Injurymentioning

confidence: 99%

Literature review of the mechanisms of acute kidney injury secondary to acute liver injury

Platt¹,

Klootwijk²,

Salama³

et al. 2022

WJN

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People exposed to liver ischaemia reperfusion (IR) injury often develop acute kidney injury and the combination is associated with significant morbidity and mortality. Molecular mediators released by the liver in response to IR injury are the likely cause of acute kidney injury (AKI) in this setting, but the mediators have not yet been identified. Identifying the mechanism of injury will allow the identification of therapeutic targets which may modulate both liver IR injury and AKI following liver IR injury.

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Kidney–liver pathophysiological crosstalk: its characteristics and importance

Cited by 50 publications

References 24 publications

Perfusate Enzymes and Platelets Indicate Early Allograft Dysfunction After Transplantation of Normothermically Preserved Livers

Perfusate Enzymes and Platelets Indicate Early Allograft Dysfunction After Transplantation of Normothermically Preserved Livers

Association of FIB-4 index and clinical outcomes in critically ill patients with acute kidney injury: a cohort study

Literature review of the mechanisms of acute kidney injury secondary to acute liver injury

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